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Items: 1 to 20 of 103

1.

Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells.

Sun Y, Guo W, Ren T, Liang W, Zhou W, Lu Q, Jiao G, Yan T.

Cell Death Dis. 2014 Jan 2;5:e979. doi: 10.1038/cddis.2013.497.

2.

Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines.

Wang K, Pan L, Che X, Cui D, Li C.

J Neurooncol. 2010 Jul;98(3):319-27. doi: 10.1007/s11060-009-0082-3. Epub 2009 Dec 19.

PMID:
20024601
3.

Arsenic trioxide inhibits growth of human chondrosarcoma cells through G2/M arrest and apoptosis as well as autophagy.

Jiao G, Ren T, Guo W, Ren C, Yang K.

Tumour Biol. 2015 May;36(5):3969-77. doi: 10.1007/s13277-015-3040-z. Epub 2015 Jan 11.

PMID:
25577250
4.

BMPR2 inhibition induced apoptosis and autophagy via destabilization of XIAP in human chondrosarcoma cells.

Jiao G, Guo W, Ren T, Lu Q, Sun Y, Liang W, Ren C, Yang K, Sun K.

Cell Death Dis. 2014 Dec 11;5:e1571. doi: 10.1038/cddis.2014.540.

5.

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.

Shimokawa T, Rahman MF, Tostar U, Sonkoly E, Ståhle M, Pivarcsi A, Palaniswamy R, Zaphiropoulos PG.

RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.

6.

LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431. Print 2013.

7.

Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.

Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.

Cancer Lett. 2013 Oct 10;339(2):185-94. doi: 10.1016/j.canlet.2013.06.010. Epub 2013 Jun 18.

PMID:
23791879
8.

Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling.

Hameetman L, Rozeman LB, Lombaerts M, Oosting J, Taminiau AH, Cleton-Jansen AM, Bovée JV, Hogendoorn PC.

J Pathol. 2006 Aug;209(4):501-11.

PMID:
16755518
9.

Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro.

Lou Z, Ren T, Peng X, Sun Y, Jiao G, Lu Q, Zhang S, Lu X, Guo W.

J Int Med Res. 2013 Oct;41(5):1505-19. doi: 10.1177/0300060513490618. Epub 2013 Aug 23.

PMID:
23975859
10.

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.

Mizuarai S, Kawagishi A, Kotani H.

Mol Cancer. 2009 Jul 6;8:44. doi: 10.1186/1476-4598-8-44.

11.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

PMID:
24094913
12.

Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells.

Wang Y, Han C, Lu L, Magliato S, Wu T.

Hepatology. 2013 Sep;58(3):995-1010. doi: 10.1002/hep.26394. Epub 2013 Jul 30.

13.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

14.

Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma.

Singh RR, Cho-Vega JH, Davuluri Y, Ma S, Kasbidi F, Milito C, Lennon PA, Drakos E, Medeiros LJ, Luthra R, Vega F.

Cancer Res. 2009 Mar 15;69(6):2550-8. doi: 10.1158/0008-5472.CAN-08-1808. Epub 2009 Feb 24.

15.

Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes.

Oji GS, Gomez P, Kurriger G, Stevens J, Morcuende JA.

Iowa Orthop J. 2007;27:9-16.

16.

Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.

Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS.

Am J Pathol. 2006 Jan;168(1):321-30.

17.

Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo.

Du WZ, Feng Y, Wang XF, Piao XY, Cui YQ, Chen LC, Lei XH, Sun X, Liu X, Wang HB, Li XF, Yang DB, Sun Y, Zhao ZF, Jiang T, Li YL, Jiang CL.

CNS Neurosci Ther. 2013 Dec;19(12):926-36. doi: 10.1111/cns.12163. Epub 2013 Oct 25.

PMID:
24165291
18.

Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.

Ren Y, Chen Z, Chen L, Woods NT, Reuther GW, Cheng JQ, Wang HG, Wu J.

J Biol Chem. 2007 Dec 14;282(50):36463-73. Epub 2007 Oct 17.

19.

Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.

Wu JY, Xu XF, Xu L, Niu PQ, Wang F, Hu GY, Wang XP, Guo CY.

Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1511-8. doi: 10.5754/hge10765. Epub 2011 Jul 15.

PMID:
21940310
20.

Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity.

Cai Q, Li J, Gao T, Xie J, Evers BM.

J Biol Chem. 2009 Jan 23;284(4):2150-8. doi: 10.1074/jbc.M803235200. Epub 2008 Nov 17.

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