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Items: 1 to 20 of 91


IG20/MADD plays a critical role in glucose-induced insulin secretion.

Li LC, Wang Y, Carr R, Haddad CS, Li Z, Qian L, Oberholzer J, Maker AV, Wang Q, Prabhakar BS.

Diabetes. 2014 May;63(5):1612-23. doi: 10.2337/db13-0707. Epub 2013 Dec 30.


MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, Prabhakar BS.

J Biol Chem. 2009 May 15;284(20):13533-41. doi: 10.1074/jbc.M808554200. Epub 2009 Mar 16.


MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival.

Mulherkar N, Ramaswamy M, Mordi DC, Prabhakar BS.

Oncogene. 2006 Oct 12;25(47):6252-61. Epub 2006 May 8.


Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.

Wagner R, Dudziak K, Herzberg-Schäfer SA, Machicao F, Stefan N, Staiger H, Häring HU, Fritsche A.

PLoS One. 2011;6(8):e23639. doi: 10.1371/journal.pone.0023639. Epub 2011 Aug 22.


DENN/MADD/IG20 alternative splicing changes and cell death in Alzheimer's disease.

Mo Y, Williams C, Miller CA.

J Mol Neurosci. 2012 Sep;48(1):97-110. doi: 10.1007/s12031-012-9782-9. Epub 2012 Jun 8.


Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene.

Li LC, Sheng JR, Mulherkar N, Prabhakar BS, Meriggioli MN.

Cancer Res. 2008 Sep 15;68(18):7352-61. doi: 10.1158/0008-5472.CAN-07-6311.


Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3.

Al-Zoubi AM, Efimova EV, Kaithamana S, Martinez O, El-Idrissi Mel-A, Dogan RE, Prabhakar BS.

J Biol Chem. 2001 Dec 14;276(50):47202-11. Epub 2001 Sep 27.


Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 are associated with glucose metabolism in the Chinese.

Hu C, Zhang R, Wang C, Wang J, Ma X, Hou X, Lu J, Yu W, Jiang F, Bao Y, Xiang K, Jia W.

PLoS One. 2010 Nov 17;5(11):e15542. doi: 10.1371/journal.pone.0015542.


Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

Cornes BK, Brody JA, Nikpoor N, Morrison AC, Dang HC, Ahn BS, Wang S, Dauriz M, Barzilay JI, Dupuis J, Florez JC, Coresh J, Gibbs RA, Kao WH, Liu CT, McKnight B, Muzny D, Pankow JS, Reid JG, White CC, Johnson AD, Wong TY, Psaty BM, Boerwinkle E, Rotter JI, Siscovick DS, Sladek R, Meigs JB.

Circ Cardiovasc Genet. 2014 Jun;7(3):374-82. doi: 10.1161/CIRCGENETICS.113.000169.


IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs.

Efimova EV, Al-Zoubi AM, Martinez O, Kaithamana S, Lu S, Arima T, Prabhakar BS.

Oncogene. 2004 Feb 5;23(5):1076-87.


Knockdown of IG20 gene expression renders thyroid cancer cells susceptible to apoptosis.

Subramanian M, Pilli T, Bhattacharya P, Pacini F, Nikiforov YE, Kanteti PV, Prabhakar BS.

J Clin Endocrinol Metab. 2009 Apr;94(4):1467-71. doi: 10.1210/jc.2008-2378. Epub 2009 Feb 3.


The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo.

Ittner AA, Bertz J, Chan TY, van Eersel J, Polly P, Ittner LM.

Diabetologia. 2014 Jul;57(7):1410-9. doi: 10.1007/s00125-014-3230-z. Epub 2014 Apr 15.


SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function.

Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG.

Diabetes. 2011 Mar;60(3):890-8. doi: 10.2337/db10-1328.


[Expression of MADD in lung adenocarcinoma tissues and its effects on proliferation and apoptosis of lung adenocarcinoma A549 cells].

Wei YP, Wu JX, Guo YF, Sun GY, Zhang Q, Bi WX, Dong L.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Apr;28(4):354-7. Chinese.


Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome.

Kai AK, Lam AK, Chen Y, Tai AC, Zhang X, Lai AK, Yeung PK, Tam S, Wang J, Lam KS, Vanhoutte PM, Bos JL, Chung SS, Xu A, Chung SK.

FASEB J. 2013 Oct;27(10):4122-35. doi: 10.1096/fj.13-230433. Epub 2013 Jun 27.


IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC.

Ramaswamy M, Efimova EV, Martinez O, Mulherkar NU, Singh SP, Prabhakar BS.

Oncogene. 2004 Aug 12;23(36):6083-94.


MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.

Turner A, Li LC, Pilli T, Qian L, Wiley EL, Setty S, Christov K, Ganesh L, Maker AV, Li P, Kanteti P, Das Gupta TK, Prabhakar BS.

PLoS One. 2013;8(2):e56817. doi: 10.1371/journal.pone.0056817. Epub 2013 Feb 15.

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