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Similar articles for PubMed (Select 24375753)


Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1.

Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH.

Ann Neurol. 2014 Feb;75(2):309-16. doi: 10.1002/ana.24093. Epub 2014 Feb 6.


Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice.

Brown JA, Emnett RJ, White CR, Yuede CM, Conyers SB, O'Malley KL, Wozniak DF, Gutmann DH.

Hum Mol Genet. 2010 Nov 15;19(22):4515-28. doi: 10.1093/hmg/ddq382. Epub 2010 Sep 7.


Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity.

Brown JA, Gianino SM, Gutmann DH.

J Neurosci. 2010 Apr 21;30(16):5579-89. doi: 10.1523/JNEUROSCI.3994-09.2010.


Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma.

Hegedus B, Hughes FW, Garbow JR, Gianino S, Banerjee D, Kim K, Ellisman MH, Brantley MA Jr, Gutmann DH.

J Neuropathol Exp Neurol. 2009 May;68(5):542-51. doi: 10.1097/NEN.0b013e3181a3240b.


Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner.

Brown JA, Diggs-Andrews KA, Gianino SM, Gutmann DH.

Mol Cell Neurosci. 2012 Jan;49(1):13-22. doi: 10.1016/j.mcn.2011.08.008. Epub 2011 Aug 26.


Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.

Warrington NM, Woerner BM, Daginakatte GC, Dasgupta B, Perry A, Gutmann DH, Rubin JB.

Cancer Res. 2007 Sep 15;67(18):8588-95.


NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma.

Solga AC, Gianino SM, Gutmann DH.

Oncogene. 2014 Jan 16;33(3):289-99. doi: 10.1038/onc.2012.580. Epub 2013 Jan 14.


Dopamine deficiency underlies learning deficits in neurofibromatosis-1 mice.

Diggs-Andrews KA, Tokuda K, Izumi Y, Zorumski CF, Wozniak DF, Gutmann DH.

Ann Neurol. 2013 Feb;73(2):309-15. doi: 10.1002/ana.23793. Epub 2012 Dec 7.


Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation.

Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH.

Cancer Res. 2008 Dec 15;68(24):10358-66. doi: 10.1158/0008-5472.CAN-08-2506.


Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma.

Kim KY, Ju WK, Hegedus B, Gutmann DH, Ellisman MH.

Neuroscience. 2010 Sep 29;170(1):178-88. doi: 10.1016/j.neuroscience.2010.06.017. Epub 2010 Jun 23.


Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging.

Su W, Xing R, Guha A, Gutmann DH, Sherman LS.

Glia. 2007 May;55(7):723-33.


Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.

Hegedus B, Banerjee D, Yeh TH, Rothermich S, Perry A, Rubin JB, Garbow JR, Gutmann DH.

Cancer Res. 2008 Mar 1;68(5):1520-8. doi: 10.1158/0008-5472.CAN-07-5916.


Neurofibromin in the brain.

Gutmann DH.

J Child Neurol. 2002 Aug;17(8):592-601; discussion 602-4, 646-51. Review.


Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.

Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR, Gutmann DH.

Cancer Res. 2003 Dec 15;63(24):8573-7.


Neurofibromin expression and astrogliosis in neurofibromatosis (type 1) brains.

Nordlund ML, Rizvi TA, Brannan CI, Ratner N.

J Neuropathol Exp Neurol. 1995 Jul;54(4):588-600.


Neurofibromatosis type 1 and sporadic optic gliomas.

Singhal S, Birch JM, Kerr B, Lashford L, Evans DG.

Arch Dis Child. 2002 Jul;87(1):65-70.


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.

Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB.

Cancer Res. 2015 Jan 1;75(1):16-21. doi: 10.1158/0008-5472.CAN-14-1891. Epub 2014 Nov 7.


Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.

Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB.

Cancer Res. 2010 Jul 15;70(14):5717-27. doi: 10.1158/0008-5472.CAN-09-3769. Epub 2010 Jun 15.


Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15996-6001. doi: 10.1073/pnas.1019012108. Epub 2011 Sep 6.

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