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Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine.

Ortega VE, Meyers DA.

J Allergy Clin Immunol. 2014 Jan;133(1):16-26. doi: 10.1016/j.jaci.2013.10.040. Review.


Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting β agonist treatment in a multiethnic asthma population: a genetic study.

Ortega VE, Hawkins GA, Moore WC, Hastie AT, Ampleford EJ, Busse WW, Castro M, Chardon D, Erzurum SC, Israel E, Montealegre F, Wenzel SE, Peters SP, Meyers DA, Bleecker ER.

Lancet Respir Med. 2014 Mar;2(3):204-13. doi: 10.1016/S2213-2600(13)70289-3. Epub 2014 Jan 27.


Pharmacogenetics of beta2 adrenergic receptor agonists in asthma management.

Ortega VE.

Clin Genet. 2014 Jul;86(1):12-20. doi: 10.1111/cge.12377. Epub 2014 Apr 7. Review.


Pharmacogenetics of the beta 2-adrenergic receptor gene.

Ortega VE, Hawkins GA, Peters SP, Bleecker ER.

Immunol Allergy Clin North Am. 2007 Nov;27(4):665-84; vii. Review.


A genome-wide association study of bronchodilator response in Latinos implicates rare variants.

Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG.

J Allergy Clin Immunol. 2014 Feb;133(2):370-8. doi: 10.1016/j.jaci.2013.06.043. Epub 2013 Aug 29.


Asthma pharmacogenetics: responding to the call for a personalized approach.

Ortega VE, Wechsler ME.

Curr Opin Allergy Clin Immunol. 2013 Aug;13(4):399-409. doi: 10.1097/ACI.0b013e3283630c19.


Polymorphism of the ADRB2 gene and response to inhaled beta- agonists in children with asthma: a meta-analysis.

Finkelstein Y, Bournissen FG, Hutson JR, Shannon M.

J Asthma. 2009 Nov;46(9):900-5. doi: 10.3109/02770900903199961.


Pharmacogenetics and the development of personalized approaches for combination therapy in asthma.

Miller SM, Ortega VE.

Curr Allergy Asthma Rep. 2013 Oct;13(5):443-52. doi: 10.1007/s11882-013-0372-x. Review.


Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response.

Ambrose HJ, Lawrance RM, Cresswell CJ, Goldman M, Meyers DA, Bleecker ER.

Respir Res. 2012 May 4;13:37. doi: 10.1186/1465-9921-13-37.


Pharmacogenetics of asthma.

Lima JJ, Blake KV, Tantisira KG, Weiss ST.

Curr Opin Pulm Med. 2009 Jan;15(1):57-62. doi: 10.1097/MCP.0b013e32831da8be. Review.


Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16.

Blake K, Cury JD, Hossain J, Tantisira K, Wang J, Mougey E, Lima J.

Pulm Pharmacol Ther. 2013 Jun;26(3):342-7. doi: 10.1016/j.pupt.2013.01.009. Epub 2013 Feb 4.


Salmeterol response is not affected by beta2-adrenergic receptor genotype in subjects with persistent asthma.

Bleecker ER, Yancey SW, Baitinger LA, Edwards LD, Klotsman M, Anderson WH, Dorinsky PM.

J Allergy Clin Immunol. 2006 Oct;118(4):809-16. Epub 2006 Aug 28.


Pharmacogenetic tests in asthma therapy.

Yu IW, Bukaveckas BL.

Clin Lab Med. 2008 Dec;28(4):645-65. doi: 10.1016/j.cll.2008.05.001. Review.


Effect of beta2-adrenergic receptor polymorphism in asthma control of patients receiving combination treatment.

Kim SH, Ye YM, Hur GY, Lee HY, Jee YK, Lee SH, Holloway JW, Park HS.

Yonsei Med J. 2009 Apr 30;50(2):182-8. doi: 10.3349/ymj.2009.50.2.182.


Acute and chronic lung function responses to salmeterol and salmeterol plus fluticasone propionate in relation to Arg16Gly beta(2)-adrenergic polymorphisms.

Yancey SW, Klotsman M, Ortega HG, Edwards LD, Anderson WH.

Curr Med Res Opin. 2009 Apr;25(4):1011-8. doi: 10.1185/03007990902805981 .


Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study.

Hawkins GA, Tantisira K, Meyers DA, Ampleford EJ, Moore WC, Klanderman B, Liggett SB, Peters SP, Weiss ST, Bleecker ER.

Am J Respir Crit Care Med. 2006 Nov 15;174(10):1101-9. Epub 2006 Aug 24.


Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.

Tantisira KG, Damask A, Szefler SJ, Schuemann B, Markezich A, Su J, Klanderman B, Sylvia J, Wu R, Martinez F, Boushey HA, Chinchilli VM, Mauger D, Weiss ST, Israel E; SHARP Investigators.

Am J Respir Crit Care Med. 2012 Jun 15;185(12):1286-91. doi: 10.1164/rccm.201111-2061OC. Epub 2012 Apr 26.


Long-acting beta2-agonists for chronic asthma in adults and children where background therapy contains varied or no inhaled corticosteroid.

Walters EH, Gibson PG, Lasserson TJ, Walters JA.

Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001385. Review.


Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China.

Fu WP, Zhao ZH, Zhong L, Sun C, Fang LZ, Liu L, Zhang JQ, Wang L, Shu JK, Wang XM, Dai LM.

Respirology. 2011 Nov;16(8):1221-7. doi: 10.1111/j.1440-1843.2011.02028.x.

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