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Results: 1 to 20 of 81

1.

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.

Ramsden D, Tweedie DJ, Chan TS, Taub ME, Li Y.

Drug Metab Dispos. 2014 Mar;42(3):394-406. doi: 10.1124/dmd.113.055897. Epub 2013 Dec 23.

PMID:
24366904
[PubMed - in process]
2.

Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.

Li Y, Zhou J, Ramsden D, Taub ME, O'Brien D, Xu J, Busacca CA, Gonnella N, Tweedie DJ.

Drug Metab Dispos. 2014 Mar;42(3):384-93. doi: 10.1124/dmd.113.055863. Epub 2013 Dec 17.

PMID:
24346834
[PubMed - in process]
3.

Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).

Ramsden D, Tweedie DJ, St George R, Chen LZ, Li Y.

Drug Metab Dispos. 2014 Mar;42(3):407-14. doi: 10.1124/dmd.113.055947. Epub 2013 Dec 23.

PMID:
24366905
[PubMed - in process]
4.

Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.

Chan TS, Yu H, Moore A, Khetani SR, Tweedie D.

Drug Metab Dispos. 2013 Dec;41(12):2024-32. doi: 10.1124/dmd.113.053397. Epub 2013 Aug 19. Erratum in: Drug Metab Dispos. 2014 Jan;42(1):200. Kehtani, Salman R [corrected to Khetani, Salman R].

PMID:
23959596
[PubMed - indexed for MEDLINE]
5.

Interplay of transporters and enzymes in drug and metabolite processing.

Pang KS, Maeng HJ, Fan J.

Mol Pharm. 2009 Nov-Dec;6(6):1734-55. doi: 10.1021/mp900258z. Review.

PMID:
19891494
[PubMed - indexed for MEDLINE]
6.

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.

Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS.

Drug Metab Dispos. 2010 Oct;38(10):1900-5. doi: 10.1124/dmd.110.034876. Epub 2010 Jul 1.

PMID:
20595376
[PubMed - indexed for MEDLINE]
Free Article
8.

New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures.

Gebhardt R, Hengstler JG, Müller D, Glöckner R, Buenning P, Laube B, Schmelzer E, Ullrich M, Utesch D, Hewitt N, Ringel M, Hilz BR, Bader A, Langsch A, Koose T, Burger HJ, Maas J, Oesch F.

Drug Metab Rev. 2003 May-Aug;35(2-3):145-213. Review.

PMID:
12959414
[PubMed - indexed for MEDLINE]
9.

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS.

Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16.

PMID:
22840492
[PubMed - indexed for MEDLINE]
10.

Hepatocytes as a tool in drug metabolism, transport and safety evaluations in drug discovery.

Sahi J, Grepper S, Smith C.

Curr Drug Discov Technol. 2010 Sep;7(3):188-98. Review.

PMID:
20843293
[PubMed - indexed for MEDLINE]
11.

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

Feng B, Xu JJ, Bi YA, Mireles R, Davidson R, Duignan DB, Campbell S, Kostrubsky VE, Dunn MC, Smith AR, Wang HF.

Toxicol Sci. 2009 Apr;108(2):492-500. doi: 10.1093/toxsci/kfp033. Epub 2009 Feb 17.

PMID:
19223659
[PubMed - indexed for MEDLINE]
Free Article
12.

Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.

Ballard TE, Orozco CC, Obach RS.

Drug Metab Dispos. 2014 May;42(5):899-902. doi: 10.1124/dmd.114.057026. Epub 2014 Mar 7.

PMID:
24608634
[PubMed - in process]
13.

The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.

Lundquist P, Lööf J, Sohlenius-Sternbeck AK, Floby E, Johansson J, Bylund J, Hoogstraate J, Afzelius L, Andersson TB.

Drug Metab Dispos. 2014 Mar;42(3):469-80. doi: 10.1124/dmd.113.054676. Epub 2014 Jan 6.

PMID:
24396146
[PubMed - in process]
14.

Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.

Walker DK, Alabaster CT, Congrave GS, Hargreaves MB, Hyland R, Jones BC, Reed LJ, Smith DA.

Drug Metab Dispos. 1996 Apr;24(4):447-55.

PMID:
8801060
[PubMed - indexed for MEDLINE]
15.

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

Emoto C, Murayama N, Rostami-Hodjegan A, Yamazaki H.

Curr Drug Metab. 2010 Oct;11(8):678-85. Review.

PMID:
20973757
[PubMed - indexed for MEDLINE]
16.

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.

Shitara Y, Maeda K, Ikejiri K, Yoshida K, Horie T, Sugiyama Y.

Biopharm Drug Dispos. 2013 Jan;34(1):45-78. doi: 10.1002/bdd.1823. Review.

PMID:
23115084
[PubMed - indexed for MEDLINE]
17.
18.

An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant.

Andersson TB, Sjöberg H, Hoffmann KJ, Boobis AR, Watts P, Edwards RJ, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Goldfarb PS, Lewis DF, Corcos L, Guillouzo A, Taavitsainen P, Pelkonen O.

Drug Metab Dispos. 2001 May;29(5):712-20.

PMID:
11302938
[PubMed - indexed for MEDLINE]
Free Article
19.

Utility of hepatocytes to model species differences in the metabolism of loxtidine and to predict pharmacokinetic parameters in rat, dog and man.

Bayliss MK, Bell JA, Jenner WN, Park GR, Wilson K.

Xenobiotica. 1999 Mar;29(3):253-68.

PMID:
10219966
[PubMed - indexed for MEDLINE]
20.

Lopinavir/ritonavir: a review of its use in the management of HIV infection.

Cvetkovic RS, Goa KL.

Drugs. 2003;63(8):769-802. Review.

PMID:
12662125
[PubMed - indexed for MEDLINE]

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