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Results: 1 to 20 of 110

1.

The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L.

Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick WH.

J Nat Prod. 2014 Jan 24;77(1):92-9. doi: 10.1021/np400727r. Epub 2013 Dec 23.

PMID:
24364476
[PubMed - indexed for MEDLINE]
2.

Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB 3rd, Diamond SL.

Mol Pharmacol. 2008 Jul;74(1):34-41. doi: 10.1124/mol.108.046219. Epub 2008 Apr 10.

PMID:
18403718
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.

Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, Arispe WM, Macdonough MT, Strecker TE, Chen SE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. doi: 10.1016/j.bmcl.2009.12.090. Epub 2010 Jan 6.

PMID:
20089402
[PubMed - indexed for MEDLINE]
4.

Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors?

Torkar A, Lenarčič B, Lah T, Dive V, Devel L.

Bioorg Med Chem Lett. 2013 May 15;23(10):2968-73. doi: 10.1016/j.bmcl.2013.03.041. Epub 2013 Mar 20.

PMID:
23562595
[PubMed - indexed for MEDLINE]
5.

A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

Shah PP, Wang T, Kaletsky RL, Myers MC, Purvis JE, Jing H, Huryn DM, Greenbaum DC, Smith AB 3rd, Bates P, Diamond SL.

Mol Pharmacol. 2010 Aug;78(2):319-24. doi: 10.1124/mol.110.064261. Epub 2010 May 13.

PMID:
20466822
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.

Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H.

J Med Chem. 2009 Sep 24;52(18):5732-47. doi: 10.1021/jm9009394.

PMID:
19715320
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides.

Guay J, Falgueyret JP, Ducret A, Percival MD, Mancini JA.

Eur J Biochem. 2000 Oct;267(20):6311-8.

PMID:
11012686
[PubMed - indexed for MEDLINE]
Free Article
8.

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

Falgueyret JP, Oballa RM, Okamoto O, Wesolowski G, Aubin Y, Rydzewski RM, Prasit P, Riendeau D, Rodan SB, Percival MD.

J Med Chem. 2001 Jan 4;44(1):94-104.

PMID:
11141092
[PubMed - indexed for MEDLINE]
9.

Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases.

Carmona E, Dufour E, Plouffe C, Takebe S, Mason P, Mort JS, Ménard R.

Biochemistry. 1996 Jun 25;35(25):8149-57.

PMID:
8679567
[PubMed - indexed for MEDLINE]
10.
11.

Distinct properties of prohormone thiol protease (PTP) compared to cathepsins B, L, and H: evidence for PTP as a novel cysteine protease.

Azaryan AV, Hook VY.

Arch Biochem Biophys. 1994 Oct;314(1):171-7.

PMID:
7944391
[PubMed - indexed for MEDLINE]
12.

Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.

Shenoy RT, Sivaraman J.

J Struct Biol. 2011 Jan;173(1):14-9. doi: 10.1016/j.jsb.2010.09.007. Epub 2010 Sep 17.

PMID:
20850545
[PubMed - indexed for MEDLINE]
13.

Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.

Song J, Jones LM, Chavarria GE, Charlton-Sevcik AK, Jantz A, Johansen A, Bayeh L, Soeung V, Snyder LK, Lade SD Jr, Chaplin DJ, Trawick ML, Pinney KG.

Bioorg Med Chem Lett. 2013 May 1;23(9):2801-7. doi: 10.1016/j.bmcl.2012.12.025. Epub 2012 Dec 20.

PMID:
23540644
[PubMed - indexed for MEDLINE]
14.

New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid.

Schirmeister T.

J Med Chem. 1999 Feb 25;42(4):560-72.

PMID:
10052963
[PubMed - indexed for MEDLINE]
15.

Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L.

Bocock JP, Edgell CJ, Marr HS, Erickson AH.

Eur J Biochem. 2003 Oct;270(19):4008-15.

PMID:
14511383
[PubMed - indexed for MEDLINE]
Free Article
16.

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

Linington RG, Clark BR, Trimble EE, Almanza A, Ureña LD, Kyle DE, Gerwick WH.

J Nat Prod. 2009 Jan;72(1):14-7. doi: 10.1021/np8003529.

PMID:
19161344
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.

Robichaud J, Oballa R, Prasit P, Falgueyret JP, Percival MD, Wesolowski G, Rodan SB, Kimmel D, Johnson C, Bryant C, Venkatraman S, Setti E, Mendonca R, Palmer JT.

J Med Chem. 2003 Aug 14;46(17):3709-27.

PMID:
12904076
[PubMed - indexed for MEDLINE]
18.

A novel photoaffinity-based probe for selective detection of cathepsin L active form.

Torkar A, Bregant S, Devel L, Novinec M, Lenarčič B, Lah T, Dive V.

Chembiochem. 2012 Nov 26;13(17):2616-21. doi: 10.1002/cbic.201200389. Epub 2012 Nov 4.

PMID:
23125066
[PubMed - indexed for MEDLINE]
19.

Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.

Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H.

J Med Chem. 2012 Dec 13;55(23):10749-65. doi: 10.1021/jm301630s. Epub 2012 Nov 26.

PMID:
23181502
[PubMed - indexed for MEDLINE]
20.

Inhibition of human liver cathepsin L by alpha 2 cysteine-proteinase inhibitor and the low-Mr cysteine proteinase inhibitor from human serum.

Pagano M, Esnard F, Engler R, Gauthier F.

Biochem J. 1984 May 15;220(1):147-55.

PMID:
6547604
[PubMed - indexed for MEDLINE]
Free PMC Article

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