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Results: 1 to 20 of 96

1.

Tumor suppressor VHL functions in the control of mitotic fidelity.

Hell MP, Duda M, Weber TC, Moch H, Krek W.

Cancer Res. 2014 May 1;74(9):2422-31. doi: 10.1158/0008-5472.CAN-13-2040. Epub 2013 Dec 20.

PMID:
24362914
[PubMed - indexed for MEDLINE]
2.

VHL loss causes spindle misorientation and chromosome instability.

Thoma CR, Toso A, Gutbrodt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, Meraldi P, Krek W.

Nat Cell Biol. 2009 Aug;11(8):994-1001. doi: 10.1038/ncb1912. Epub 2009 Jul 20.

PMID:
19620968
[PubMed - indexed for MEDLINE]
3.

miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation.

Hell MP, Thoma CR, Fankhauser N, Christinat Y, Weber TC, Krek W.

Cancer Res. 2014 May 1;74(9):2432-43. doi: 10.1158/0008-5472.CAN-13-2041. Epub 2014 Feb 3.

PMID:
24491803
[PubMed - indexed for MEDLINE]
4.

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.

Albers J, Rajski M, Schönenberger D, Harlander S, Schraml P, von Teichman A, Georgiev S, Wild PJ, Moch H, Krek W, Frew IJ.

EMBO Mol Med. 2013 Jun;5(6):949-64. doi: 10.1002/emmm.201202231. Epub 2013 Apr 22.

PMID:
23606570
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.

Haase VH.

Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):564-74. Epub 2005 Apr 26. Review.

PMID:
15908240
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.

Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, Maher ER.

Cancer Res. 2002 Jul 1;62(13):3803-11.

PMID:
12097293
[PubMed - indexed for MEDLINE]
Free Article
7.

Von hippel-lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development.

Kuehn EW, Walz G, Benzing T.

Cancer Res. 2007 May 15;67(10):4537-40. Review.

PMID:
17510376
[PubMed - indexed for MEDLINE]
Free Article
8.

Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).

Martin B, Chesnel F, Delcros JG, Jouan F, Couturier A, Dugay F, Le Goff X, Patard JJ, Fergelot P, Vigneau C, Rioux-Leclerq N, Arlot-Bonnemains Y.

PLoS One. 2013 Jun 13;8(6):e67071. doi: 10.1371/journal.pone.0067071. Print 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/d506055a-d16b-4c0c-aef6-ad39e91a3b8d.

PMID:
23785518
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.

Zhou L, Yang H.

PLoS One. 2011;6(9):e23936. doi: 10.1371/journal.pone.0023936. Epub 2011 Sep 16.

PMID:
21949687
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function.

Sinha S, Mondal G, Hwang EJ, Han da W, Dutta SK, Iyer S, Karumanchi SA, Kim KI, Couch FJ, Mukhopadhyay D.

J Cell Sci. 2011 Jul 1;124(Pt 13):2132-42. doi: 10.1242/jcs.087122. Epub 2011 Jun 7.

PMID:
21652636
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The von Hippel-Lindau tumor suppressor gene and kidney cancer.

Kaelin WG Jr.

Clin Cancer Res. 2004 Sep 15;10(18 Pt 2):6290S-5S. Review.

PMID:
15448019
[PubMed - indexed for MEDLINE]
Free Article
12.

Hypoxia upregulates von Hippel-Lindau tumor-suppressor protein through RhoA-dependent activity in renal cell carcinoma.

Turcotte S, Desrosiers RR, Beliveau R.

Am J Physiol Renal Physiol. 2004 Feb;286(2):F338-48. Epub 2003 Oct 28.

PMID:
14583436
[PubMed - indexed for MEDLINE]
Free Article
13.

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms.

Calzada MJ, Esteban MA, Feijoo-Cuaresma M, Castellanos MC, Naranjo-Suárez S, Temes E, Méndez F, Yánez-Mo M, Ohh M, Landázuri MO.

Cancer Res. 2006 Feb 1;66(3):1553-60.

PMID:
16452212
[PubMed - indexed for MEDLINE]
Free Article
14.

Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma.

An J, Liu H, Magyar CE, Guo Y, Veena MS, Srivatsan ES, Huang J, Rettig MB.

Cancer Res. 2013 Feb 15;73(4):1374-85. doi: 10.1158/0008-5472.CAN-12-2362. Epub 2013 Feb 7.

PMID:
23393199
[PubMed - indexed for MEDLINE]
Free Article
15.

JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma.

Kanno T, Kamba T, Yamasaki T, Shibasaki N, Saito R, Terada N, Toda Y, Mikami Y, Inoue T, Kanematsu A, Nishiyama H, Ogawa O, Nakamura E.

Oncogene. 2012 Jun 21;31(25):3098-110. doi: 10.1038/onc.2011.475. Epub 2011 Oct 24.

PMID:
22020339
[PubMed - indexed for MEDLINE]
16.

Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein.

Kaelin WG Jr.

Cancer. 2009 May 15;115(10 Suppl):2262-72. doi: 10.1002/cncr.24232. Review.

PMID:
19402056
[PubMed - indexed for MEDLINE]
Free Article
17.

Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma.

Luu VD, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild PJ, Sulser T, Schraml P, Moch H.

Clin Cancer Res. 2009 May 15;15(10):3297-304. doi: 10.1158/1078-0432.CCR-08-2779. Epub 2009 Apr 28.

PMID:
19401348
[PubMed - indexed for MEDLINE]
Free Article
18.

Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness.

He X, Wang J, Messing EM, Wu G.

Oncogene. 2011 Feb 3;30(5):535-47. doi: 10.1038/onc.2010.427. Epub 2010 Sep 27.

PMID:
20871634
[PubMed - indexed for MEDLINE]
19.

pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma.

Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H.

J Pathol. 2008 Mar;214(4):464-71. doi: 10.1002/path.2310.

PMID:
18189328
[PubMed - indexed for MEDLINE]
20.

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH.

Cancer Res. 2006 Apr 1;66(7):3567-75.

PMID:
16585181
[PubMed - indexed for MEDLINE]
Free Article
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