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Results: 1 to 20 of 108

1.

Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.

Li YH, Bi HC, Huang L, Jin J, Zhong GP, Zhou XN, Huang M.

Acta Pharmacol Sin. 2014 Feb;35(2):283-91. doi: 10.1038/aps.2013.157. Epub 2013 Dec 23.

PMID:
24362330
[PubMed - indexed for MEDLINE]
2.

Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Yu XY, Lin SG, Zhou ZW, Chen X, Liang J, Liu PQ, Duan W, Chowbay B, Wen JY, Li CG, Zhou SF.

Curr Drug Metab. 2007 May;8(4):325-40.

PMID:
17504222
[PubMed - indexed for MEDLINE]
3.

Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.

Cao J, Chen X, Liang J, Yu XQ, Xu AL, Chan E, Wei D, Huang M, Wen JY, Yu XY, Li XT, Sheu FS, Zhou SF.

Drug Metab Dispos. 2007 Apr;35(4):539-53. Epub 2007 Jan 12.

PMID:
17220245
[PubMed - indexed for MEDLINE]
Free Article
4.

Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models.

Fan Y, Rodriguez-Proteau R.

Xenobiotica. 2008 Feb;38(2):107-29. doi: 10.1080/00498250701744625 .

PMID:
18197554
[PubMed - indexed for MEDLINE]
5.

Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.

Taub ME, Podila L, Ely D, Almeida I.

Drug Metab Dispos. 2005 Nov;33(11):1679-87. Epub 2005 Aug 10.

PMID:
16093365
[PubMed - indexed for MEDLINE]
Free Article
6.

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

Tang F, Horie K, Borchardt RT.

Pharm Res. 2002 Jun;19(6):765-72.

PMID:
12134945
[PubMed - indexed for MEDLINE]
8.

Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.

Acharya P, O'Connor MP, Polli JW, Ayrton A, Ellens H, Bentz J.

Drug Metab Dispos. 2008 Feb;36(2):452-60. Epub 2007 Oct 29.

PMID:
17967933
[PubMed - indexed for MEDLINE]
Free Article
9.

Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport.

Shirasaka Y, Kawasaki M, Sakane T, Omatsu H, Moriya Y, Nakamura T, Sakaeda T, Okumura K, Langguth P, Yamashita S.

Drug Metab Pharmacokinet. 2006 Oct;21(5):414-23.

PMID:
17072095
[PubMed - indexed for MEDLINE]
Free Article
10.

Evidence for a non-MDR1 component in digoxin secretion by human intestinal Caco-2 epithelial layers.

Lowes S, Cavet ME, Simmons NL.

Eur J Pharmacol. 2003 Jan 1;458(1-2):49-56.

PMID:
12498906
[PubMed - indexed for MEDLINE]
11.

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG.

Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4.

PMID:
23382458
[PubMed - indexed for MEDLINE]
Free Article
12.

P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.

Oga EF, Sekine S, Shitara Y, Horie T.

J Ethnopharmacol. 2012 Dec 18;144(3):612-7. doi: 10.1016/j.jep.2012.10.001. Epub 2012 Oct 11.

PMID:
23064285
[PubMed - indexed for MEDLINE]
13.

Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor.

Agarwal S, Pal D, Mitra AK.

Int J Pharm. 2007 Jul 18;339(1-2):139-47. Epub 2007 Mar 6.

PMID:
17451894
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.

Lumen AA, Li L, Li J, Ahmed Z, Meng Z, Owen A, Ellens H, Hidalgo IJ, Bentz J.

PLoS One. 2013 Aug 16;8(8):e69394. doi: 10.1371/journal.pone.0069394. eCollection 2013.

PMID:
23976943
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Potential role for human P-glycoprotein in the transport of lacosamide.

Zhang C, Chanteux H, Zuo Z, Kwan P, Baum L.

Epilepsia. 2013 Jul;54(7):1154-60. doi: 10.1111/epi.12158. Epub 2013 Mar 29.

PMID:
23551115
[PubMed - indexed for MEDLINE]
16.

Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).

Nies AT, Herrmann E, Brom M, Keppler D.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Feb;376(6):449-61. Epub 2007 Dec 19.

PMID:
18157518
[PubMed - indexed for MEDLINE]
17.

The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells.

Ye L, Yang X, Yang Z, Gao S, Yin T, Liu W, Wang F, Hu M, Liu Z.

Toxicol Lett. 2013 Feb 4;216(2-3):86-99. doi: 10.1016/j.toxlet.2012.11.011. Epub 2012 Nov 28.

PMID:
23200901
[PubMed - indexed for MEDLINE]
18.

Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors.

Profit L, Eagling VA, Back DJ.

AIDS. 1999 Sep 10;13(13):1623-7.

PMID:
10509562
[PubMed - indexed for MEDLINE]
19.

Functional characterization of peptide transporters in MDCKII-MDR1 cell line as a model for oral absorption studies.

Agarwal S, Jain R, Pal D, Mitra AK.

Int J Pharm. 2007 Mar 6;332(1-2):147-52. Epub 2006 Oct 10.

PMID:
17097248
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.

Pauli-Magnus C, von Richter O, Burk O, Ziegler A, Mettang T, Eichelbaum M, Fromm MF.

J Pharmacol Exp Ther. 2000 May;293(2):376-82.

PMID:
10773005
[PubMed - indexed for MEDLINE]
Free Article

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