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Gsta4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity.

McElhanon KE, Bose C, Sharma R, Wu L, Awasthi YC, Singh SP.

Open J Apoptosis. 2013 Jan 1;2(1). doi: 10.4236/ojapo.2013.21001.


Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis.

Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J.

J Pathol. 2012 Dec;228(4):448-58. doi: 10.1002/path.4067. Epub 2012 Jul 26.


Protection from oxidative and electrophilic stress in the Gsta4-null mouse heart.

Beneš H, Vuong MK, Boerma M, McElhanon KE, Siegel ER, Singh SP.

Cardiovasc Toxicol. 2013 Dec;13(4):347-56. doi: 10.1007/s12012-013-9215-1.


Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

Yang Y, Sharma R, Sharma A, Awasthi S, Awasthi YC.

Acta Biochim Pol. 2003;50(2):319-36. Review.


Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse.

Engle MR, Singh SP, Czernik PJ, Gaddy D, Montague DC, Ceci JD, Yang Y, Awasthi S, Awasthi YC, Zimniak P.

Toxicol Appl Pharmacol. 2004 Feb 1;194(3):296-308.


Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.

Singh R, Wang Y, Schattenberg JM, Xiang Y, Czaja MJ.

Am J Physiol Gastrointest Liver Physiol. 2009 Nov;297(5):G907-17.


Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells.

Vatsyayan R, Chaudhary P, Sharma A, Sharma R, Rao Lelsani PC, Awasthi S, Awasthi YC.

Exp Eye Res. 2011 Feb;92(2):147-54. doi: 10.1016/j.exer.2010.11.010. Epub 2010 Dec 4.


Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury.

Gallagher EP, Huisden CM, Gardner JL.

Toxicol In Vitro. 2007 Dec;21(8):1365-72. Epub 2007 Apr 27.


Selective activation of the c-Jun N-terminal protein kinase pathway during 4-hydroxynonenal-induced apoptosis of PC12 cells.

Soh Y, Jeong KS, Lee IJ, Bae MA, Kim YC, Song BJ.

Mol Pharmacol. 2000 Sep;58(3):535-41.


4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase.

Vaillancourt F, Fahmi H, Shi Q, Lavigne P, Ranger P, Fernandes JC, Benderdour M.

Arthritis Res Ther. 2008;10(5):R107. doi: 10.1186/ar2503. Epub 2008 Sep 9.


The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4.

Vatsyayan R, Lelsani PC, Chaudhary P, Kumar S, Awasthi S, Awasthi YC.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):346-51. doi: 10.1016/j.bbrc.2011.11.113. Epub 2011 Dec 1.


Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal.

Shi Q, Vaillancourt F, Côté V, Fahmi H, Lavigne P, Afif H, Di Battista JA, Fernandes JC, Benderdour M.

Arthritis Res Ther. 2006;8(6):R159.


Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.

Cheng JZ, Sharma R, Yang Y, Singhal SS, Sharma A, Saini MK, Singh SV, Zimniak P, Awasthi S, Awasthi YC.

J Biol Chem. 2001 Nov 2;276(44):41213-23. Epub 2001 Aug 24.


Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.

Cheng JZ, Singhal SS, Sharma A, Saini M, Yang Y, Awasthi S, Zimniak P, Awasthi YC.

Arch Biochem Biophys. 2001 Aug 15;392(2):197-207.


Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway.

Song BJ, Soh Y, Bae M, Pie J, Wan J, Jeong K.

Chem Biol Interact. 2001 Jan 30;130-132(1-3):943-54.


Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.

Balogh LM, Le Trong I, Kripps KA, Shireman LM, Stenkamp RE, Zhang W, Mannervik B, Atkins WM.

Biochemistry. 2010 Feb 23;49(7):1541-8. doi: 10.1021/bi902038u.


4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.

Sharma A, Sharma R, Chaudhary P, Vatsyayan R, Pearce V, Jeyabal PV, Zimniak P, Awasthi S, Awasthi YC.

Arch Biochem Biophys. 2008 Dec 15;480(2):85-94. doi: 10.1016/ Epub 2008 Oct 7.

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