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Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.

Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):840-6. doi: 10.1016/j.bbrc.2013.12.061. Epub 2013 Dec 14.


Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis.

Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M.

Inflamm Bowel Dis. 2011 Nov;17(11):2251-60. doi: 10.1002/ibd.21611. Epub 2011 Jan 6.


Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway.

Lee JH, Suk J, Park J, Kim SB, Kwak SS, Kim JW, Lee CH, Byun B, Ahn JK, Joe CO.

Mol Cancer Res. 2009 Oct;7(10):1663-71. doi: 10.1158/1541-7786.MCR-09-0191. Epub 2009 Oct 6.


High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission.

Xu AT, Li Y, Zhao D, Shen J, Xu XT, Qiao YQ, Zhu MM, Wang TR, Cui Y, Ai LY, Ran ZH.

Inflamm Bowel Dis. 2015 Feb;21(2):241-50. doi: 10.1097/MIB.0000000000000267.


Requirement of Notch activation during regeneration of the intestinal epithelia.

Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M.

Am J Physiol Gastrointest Liver Physiol. 2009 Jan;296(1):G23-35. doi: 10.1152/ajpgi.90225.2008. Epub 2008 Nov 20.


H. pylori induces the expression of Hath1 in gastric epithelial cells via interleukin-8/STAT3 phosphorylation while suppressing Hes1.

Zhang X, Yang Y, Zhu R, Bai J, Tian Y, Li X, Peng Z, He Y, Chen L, Fang D, Chen W, Zou Q, Mao X, Wang R.

J Cell Biochem. 2012 Dec;113(12):3740-51. doi: 10.1002/jcb.24248.


Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells.

Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y.

Blood. 2011 Jul 21;118(3):586-93. doi: 10.1182/blood-2011-02-334995. Epub 2011 May 23.


MAML1 regulates cell viability via the NF-κB pathway in cervical cancer cell lines.

Kuncharin Y, Sangphech N, Kueanjinda P, Bhattarakosol P, Palaga T.

Exp Cell Res. 2011 Aug 1;317(13):1830-40. doi: 10.1016/j.yexcr.2011.05.005. Epub 2011 May 24.


Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.

Murata J, Ohtsuka T, Tokunaga A, Nishiike S, Inohara H, Okano H, Kageyama R.

J Neurosci Res. 2009 Dec;87(16):3521-34. doi: 10.1002/jnr.22169.


Hes1 is required for contact inhibition of cell proliferation in 3T3-L1 preadipocytes.

Noda N, Honma S, Ohmiya Y.

Genes Cells. 2011 Jun;16(6):704-13. doi: 10.1111/j.1365-2443.2011.01518.x. Epub 2011 Apr 12.


Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.

Zhang P, Yang Y, Nolo R, Zweidler-McKay PA, Hughes DP.

Oncogene. 2010 May 20;29(20):2916-26. doi: 10.1038/onc.2010.62. Epub 2010 Mar 8. Erratum in: Oncogene. 2012 Nov 1;31(44):4732.


Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling.

Kobayashi T, Kageyama R.

Genes Cells. 2010 Jun;15(7):689-98. doi: 10.1111/j.1365-2443.2010.01413.x. Epub 2010 Jun 10.


Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.

Zhou X, Smith AJ, Waterhouse A, Blin G, Malaguti M, Lin CY, Osorno R, Chambers I, Lowell S.

Stem Cells. 2013 Aug;31(8):1511-22. doi: 10.1002/stem.1426.


Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein.

Li GH, Fan YZ, Liu XW, Zhang BF, Yin DD, He F, Huang SY, Kang ZJ, Xu H, Liu Q, Wu YL, Niu XL, Zhang L, Liu L, Hao MW, Han H, Liang YM.

Mol Cell Biochem. 2010 Jul;340(1-2):7-14. doi: 10.1007/s11010-010-0394-9. Epub 2010 Feb 16.


HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

Wong GW, Knowles GC, Mak TW, Ferrando AA, Zúñiga-Pflücker JC.

Blood. 2012 Aug 16;120(7):1439-48. doi: 10.1182/blood-2011-12-395319. Epub 2012 May 30.


Multiple roles of Notch signaling in the regulation of epidermal development.

Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M.

Dev Cell. 2008 Apr;14(4):594-604. doi: 10.1016/j.devcel.2008.01.017.


Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative colitis.

Lee MJ, Lee JK, Choi JW, Lee CS, Sim JH, Cho CH, Lee KH, Cho IH, Chung MH, Kim HR, Ye SK.

PLoS One. 2012;7(9):e38801. doi: 10.1371/journal.pone.0038801. Epub 2012 Sep 4.


STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing.

Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C.

J Exp Med. 2009 Jul 6;206(7):1465-72. doi: 10.1084/jem.20082683. Epub 2009 Jun 29.


Abnormal differentiation of intestinal epithelium and intestinal barrier dysfunction in diabetic mice associated with depressed Notch/NICD transduction in Notch/Hes1 signal pathway.

Min XH, Yu T, Qing Q, Yuan YH, Zhong W, Chen GC, Zhao LN, Deng N, Zhang LF, Chen QK.

Cell Biol Int. 2014 Oct;38(10):1194-204. doi: 10.1002/cbin.10323. Epub 2014 Jun 6.

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