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Tim-3: an activation marker and activation limiter of innate immune cells.

Han G, Chen G, Shen B, Li Y.

Front Immunol. 2013 Dec 10;4:449. doi: 10.3389/fimmu.2013.00449. Review.


TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.

Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH.

Immunol Rev. 2010 May;235(1):172-89. doi: 10.1111/j.0105-2896.2010.00903.x. Review.


Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes.

Zhang Y, Ma CJ, Wang JM, Ji XJ, Wu XY, Moorman JP, Yao ZQ.

J Leukoc Biol. 2012 Feb;91(2):189-96. doi: 10.1189/jlb.1010591. Epub 2011 Aug 15.


HIV infection deregulates Tim-3 expression on innate cells: combination antiretroviral therapy results in partial restoration.

Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy M, Kain KC, Serghides L.

J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):161-7. doi: 10.1097/QAI.0b013e318285cf13.


Human pregnancy up-regulates Tim-3 in innate immune cells for systemic immunity.

Zhao J, Lei Z, Liu Y, Li B, Zhang L, Fang H, Song C, Wang X, Zhang GM, Feng ZH, Huang B.

J Immunol. 2009 May 15;182(10):6618-24. doi: 10.4049/jimmunol.0803876.


TIM-3 Regulates Distinct Functions in Macrophages.

OcaƱa-Guzman R, Torre-Bouscoulet L, Sada-Ovalle I.

Front Immunol. 2016 Jun 13;7:229. doi: 10.3389/fimmu.2016.00229. eCollection 2016. Review.


The role of T cell immunoglobulin and mucin domain-3 in immune thrombocytopenia.

Zhang XM, Shan NN.

Scand J Immunol. 2014 Apr;79(4):231-6. doi: 10.1111/sji.12153. Review.


Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection.

Zhang Y, Ma CJ, Wang JM, Ji XJ, Wu XY, Jia ZS, Moorman JP, Yao ZQ.

PLoS One. 2011;6(5):e19664. doi: 10.1371/journal.pone.0019664. Epub 2011 May 26.


TIM-3 and its regulatory role in immune responses.

Zhu C, Anderson AC, Kuchroo VK.

Curr Top Microbiol Immunol. 2011;350:1-15. doi: 10.1007/82_2010_84. Review.


Role of Tim-3 in hepatitis B virus infection: An overview.

Liu Y, Gao LF, Liang XH, Ma CH.

World J Gastroenterol. 2016 Feb 21;22(7):2294-303. doi: 10.3748/wjg.v22.i7.2294. Review.


Emerging Tim-3 functions in antimicrobial and tumor immunity.

Sakuishi K, Jayaraman P, Behar SM, Anderson AC, Kuchroo VK.

Trends Immunol. 2011 Aug;32(8):345-9. doi: 10.1016/ Epub 2011 Jun 21. Review.


T cell immunoglobulin-3 as a new therapeutic target for rheumatoid arthritis.

Li X, Zhao YQ, Li CW, Yuan FL.

Expert Opin Ther Targets. 2012 Dec;16(12):1145-9. doi: 10.1517/14728222.2012.726616. Epub 2012 Sep 22. Review.


Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection.

Jost S, Moreno-Nieves UY, Garcia-Beltran WF, Rands K, Reardon J, Toth I, Piechocka-Trocha A, Altfeld M, Addo MM.

Retrovirology. 2013 Jul 18;10:74. doi: 10.1186/1742-4690-10-74.


The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.

Li Y, Feng J, Geng S, Geng S, Wei H, Chen G, Li X, Wang L, Wang R, Peng H, Han G, Shen B, Li Y.

Mol Immunol. 2011 Jan;48(4):670-7. doi: 10.1016/j.molimm.2010.11.011. Epub 2010 Dec 10.


T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.

Yang X, Jiang X, Chen G, Xiao Y, Geng S, Kang C, Zhou T, Li Y, Guo X, Xiao H, Hou C, Wang R, Lin Z, Li X, Feng J, Ma Y, Shen B, Li Y, Han G.

J Immunol. 2013 Mar 1;190(5):2068-79. doi: 10.4049/jimmunol.1202661. Epub 2013 Jan 30.


Innate and adaptive immune pathways to tolerance.

Thornton CA, Morgan G.

Nestle Nutr Workshop Ser Pediatr Program. 2009;64:45-57; discussion 57-61, 251-7. doi: 10.1159/000235782. Epub 2009 Aug 19.


Dysregulated upregulation of T-cell immunoglobulin and mucin domain-3 on mucosal T helper 1 cells in patients with Crohn's disease.

Morimoto K, Hosomi S, Yamagami H, Watanabe K, Kamata N, Sogawa M, Machida H, Okazaki H, Tanigawa T, Nagahara H, Noda E, Tominaga K, Watanabe T, Fujiwara Y, Maeda K, Hirakawa K, Arakawa T.

Scand J Gastroenterol. 2011 Jun;46(6):701-9. doi: 10.3109/00365521.2011.568518. Epub 2011 Apr 5.


TIM family of genes in immunity and tolerance.

Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH.

Adv Immunol. 2006;91:227-49. Review.


Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis.

Prezzemolo T, Guggino G, La Manna MP, Di Liberto D, Dieli F, Caccamo N.

Front Immunol. 2014 Apr 22;5:180. doi: 10.3389/fimmu.2014.00180. eCollection 2014. Review.


Involvement of Galectin-9/TIM-3 pathway in the systemic inflammatory response in early-onset preeclampsia.

Miko E, Meggyes M, Bogar B, Schmitz N, Barakonyi A, Varnagy A, Farkas B, Tamas P, Bodis J, Szekeres-Bartho J, Illes Z, Szereday L.

PLoS One. 2013 Aug 2;8(8):e71811. doi: 10.1371/journal.pone.0071811. Print 2013.

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