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Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772.

Chattopadhyay R, Dyukova E, Singh NK, Ohba M, Mobley JA, Rao GN.

J Biol Chem. 2014 Feb 7;289(6):3148-63. doi: 10.1074/jbc.M113.528190. Epub 2013 Dec 15.


12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction.

Kundumani-Sridharan V, Dyukova E, Hansen DE 3rd, Rao GN.

J Biol Chem. 2013 May 31;288(22):15830-42. doi: 10.1074/jbc.M113.453290. Epub 2013 Apr 15.


12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction.

Chattopadhyay R, Tinnikov A, Dyukova E, Singh NK, Kotla S, Mobley JA, Rao GN.

J Lipid Res. 2015 Mar;56(3):562-77. doi: 10.1194/jlr.M055566. Epub 2015 Jan 3.


Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells.

Zhang X, Wang T, Gui P, Yao C, Sun W, Wang L, Wang H, Xie W, Yao S, Lin Y, Wu Q.

Oxid Med Cell Longev. 2013;2013:185715. doi: 10.1155/2013/185715. Epub 2013 Dec 5.


Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-β.

Schamberger AC, Mise N, Jia J, Genoyer E, Yildirim AÖ, Meiners S, Eickelberg O.

Am J Respir Cell Mol Biol. 2014 Jun;50(6):1040-52. doi: 10.1165/rcmb.2013-0090OC.


Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms.

Quinn M, McMillin M, Galindo C, Frampton G, Pae HY, DeMorrow S.

Dig Liver Dis. 2014 Jun;46(6):527-34. doi: 10.1016/j.dld.2014.01.159. Epub 2014 Mar 12.


Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium.

Samak G, Chaudhry KK, Gangwar R, Narayanan D, Jaggar JH, Rao R.

Biochem J. 2015 Feb 1;465(3):503-15. doi: 10.1042/BJ20140450.


The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation.

Goldblum SE, Rai U, Tripathi A, Thakar M, De Leo L, Di Toro N, Not T, Ramachandran R, Puche AC, Hollenberg MD, Fasano A.

FASEB J. 2011 Jan;25(1):144-58. doi: 10.1096/fj.10-158972. Epub 2010 Sep 17.


Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway.

Liu W, Wang P, Shang C, Chen L, Cai H, Ma J, Yao Y, Shang X, Xue Y.

Brain Res. 2014 Jul 21;1573:17-26. doi: 10.1016/j.brainres.2014.05.022. Epub 2014 May 20.


Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise.

Haorah J, Heilman D, Knipe B, Chrastil J, Leibhart J, Ghorpade A, Miller DW, Persidsky Y.

Alcohol Clin Exp Res. 2005 Jun;29(6):999-1009.


Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation.

Wu HL, Gao X, Jiang ZD, Duan ZT, Wang SK, He BS, Zhang ZY, Xie HG.

Toxicology. 2013 Feb 8;304:41-8. doi: 10.1016/j.tox.2012.11.020. Epub 2012 Dec 7.


p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes.

Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, Kähäri VM, Peltonen S.

Arch Dermatol Res. 2014 Mar;306(2):131-41. doi: 10.1007/s00403-013-1391-0. Epub 2013 Jul 16.


Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junction.

Zimmerman SP, Hueschen CL, Malide D, Milgram SL, Playford MP.

Biochem J. 2013 Oct 1;455(1):95-106. doi: 10.1042/BJ20121755.


Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.

Sabath E, Negoro H, Beaudry S, Paniagua M, Angelow S, Shah J, Grammatikakis N, Yu AS, Denker BM.

J Cell Sci. 2008 Mar 15;121(Pt 6):814-24. doi: 10.1242/jcs.014878. Epub 2008 Feb 19.


Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway.

Petecchia L, Sabatini F, Usai C, Caci E, Varesio L, Rossi GA.

Lab Invest. 2012 Aug;92(8):1140-8.


Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.

Qiao X, Roth I, Féraille E, Hasler U.

Cell Cycle. 2014;13(19):3059-75. doi: 10.4161/15384101.2014.949091.


Association between adherens junctions and tight junctions via Rap1 promotes barrier protective effects of oxidized phospholipids.

Birukova AA, Zebda N, Fu P, Poroyko V, Cokic I, Birukov KG.

J Cell Physiol. 2011 Aug;226(8):2052-62. doi: 10.1002/jcp.22543.


Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells.

Szekeres CK, Tang K, Trikha M, Honn KV.

J Biol Chem. 2000 Dec 8;275(49):38831-41.

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