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Results: 1 to 20 of 127

Similar articles for PubMed (Select 24338474)

1.

Signature amyloid β profiles are produced by different γ-secretase complexes.

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B.

J Biol Chem. 2014 Feb 14;289(7):4346-55. doi: 10.1074/jbc.M113.530907. Epub 2013 Dec 13.

2.

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS.

Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30.

3.

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.

Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S.

J Biol Chem. 2011 Dec 30;286(52):44569-75. doi: 10.1074/jbc.M111.270108. Epub 2011 Nov 10.

4.

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.

Neurobiol Dis. 2007 Jul;27(1):102-7. Epub 2007 May 6.

PMID:
17560791
5.

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B.

Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19.

6.

Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease.

Svedružić ZM, Popović K, Smoljan I, Sendula-Jengić V.

PLoS One. 2012;7(3):e32293. doi: 10.1371/journal.pone.0032293. Epub 2012 Mar 30.

7.

Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.

Pintchovski SA, Schenk DB, Basi GS.

Curr Alzheimer Res. 2013 Jan;10(1):4-10.

8.

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.

9.

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.

Fernandez MA, Klutkowski JA, Freret T, Wolfe MS.

J Biol Chem. 2014 Nov 7;289(45):31043-52. doi: 10.1074/jbc.M114.581165. Epub 2014 Sep 19.

PMID:
25239621
10.

γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.

Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M.

J Cell Mol Med. 2011 Oct;15(10):2150-63. doi: 10.1111/j.1582-4934.2010.01208.x.

11.

Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

Winkler E, Kamp F, Scheuring J, Ebke A, Fukumori A, Steiner H.

J Biol Chem. 2012 Jun 15;287(25):21326-34. doi: 10.1074/jbc.M112.356659. Epub 2012 Apr 24.

12.

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H.

J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27.

13.

Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).

Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH.

J Biol Chem. 2012 Nov 23;287(48):40629-40. doi: 10.1074/jbc.M112.418442. Epub 2012 Oct 5.

14.

Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.

Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G.

J Biol Chem. 2013 May 24;288(21):15352-66. doi: 10.1074/jbc.M112.441840. Epub 2013 Apr 15.

15.

γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ.

Liu F, Xue ZQ, Deng SH, Kun X, Luo XG, Patrylo PR, Rose GM, Cai H, Struble RG, Cai Y, Yan XX.

Eur J Neurosci. 2013 May;37(10):1714-25. doi: 10.1111/ejn.12159. Epub 2013 Feb 22. Erratum in: Eur J Neurosci. 2013 Jul;38(2):2340.

16.

Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.

PMID:
23225010
17.

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S.

J Biol Chem. 2008 Jun 20;283(25):17049-54. doi: 10.1074/jbc.M802912200. Epub 2008 Apr 21.

18.

Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.

Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K.

Neurodegener Dis. 2009;6(5-6):258-62. doi: 10.1159/000264639. Epub 2009 Dec 3.

19.
20.

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.

Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K.

Biochem Biophys Res Commun. 2003 Jun 6;305(3):502-9. Erratum in: Biochem Biophys Res Commun. 2003 Aug 1;307(3):756.

PMID:
12763021
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