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Results: 1 to 20 of 90

1.

Insig proteins mediate feedback inhibition of cholesterol synthesis in the intestine.

McFarlane MR, Liang G, Engelking LJ.

J Biol Chem. 2014 Jan 24;289(4):2148-56. doi: 10.1074/jbc.M113.524041. Epub 2013 Dec 11.

PMID:
24337570
[PubMed - indexed for MEDLINE]
2.

Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.

Rodrigue-Way A, Caron V, Bilodeau S, Keil S, Hassan M, Lévy E, Mitchell GA, Tremblay A.

FASEB J. 2014 Apr;28(4):1910-23. doi: 10.1096/fj.13-240168. Epub 2013 Dec 26.

PMID:
24371122
[PubMed - indexed for MEDLINE]
3.

Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes.

Engelking LJ, McFarlane MR, Li CK, Liang G.

J Lipid Res. 2012 Jul;53(7):1359-68. doi: 10.1194/jlr.M027599. Epub 2012 Apr 22.

PMID:
22523394
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS.

J Clin Invest. 2005 Sep;115(9):2489-98. Epub 2005 Aug 11.

PMID:
16100574
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.

Kovacs WJ, Tape KN, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL.

J Biol Chem. 2009 Mar 13;284(11):7232-45. doi: 10.1074/jbc.M809064200. Epub 2008 Dec 24.

PMID:
19110480
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

Lee PC, Sever N, Debose-Boyd RA.

J Biol Chem. 2005 Jul 1;280(26):25242-9. Epub 2005 May 2.

PMID:
15866869
[PubMed - indexed for MEDLINE]
Free Article
7.

Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells.

Jesch ED, Seo JM, Carr TP, Lee JY.

Nutr Res. 2009 Dec;29(12):859-66. doi: 10.1016/j.nutres.2009.10.016.

PMID:
19963159
[PubMed - indexed for MEDLINE]
8.

Gene expression of sterol regulatory element-binding proteins in hamster small intestine.

Field FJ, Born E, Murthy S, Mathur SN.

J Lipid Res. 2001 Jan;42(1):1-8.

PMID:
11160359
[PubMed - indexed for MEDLINE]
Free Article
9.

Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2.

König B, Koch A, Spielmann J, Hilgenfeld C, Stangl GI, Eder K.

Biochem Pharmacol. 2007 Feb 15;73(4):574-85. Epub 2006 Nov 10.

PMID:
17126302
[PubMed - indexed for MEDLINE]
10.

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.

Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J.

Cell Metab. 2006 Jan;3(1):15-24.

PMID:
16399501
[PubMed - indexed for MEDLINE]
Free Article
11.

Dual functions of Insig proteins in cholesterol homeostasis.

Dong XY, Tang SQ, Chen JD.

Lipids Health Dis. 2012 Dec 18;11:173. doi: 10.1186/1476-511X-11-173. Review.

PMID:
23249523
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice.

Kovacs WJ, Charles KN, Walter KM, Shackelford JE, Wikander TM, Richards MJ, Fliesler SJ, Krisans SK, Faust PL.

Biochim Biophys Acta. 2012 Jun;1821(6):895-907. doi: 10.1016/j.bbalip.2012.02.011. Epub 2012 Mar 13.

PMID:
22441164
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Sever N, Lee PC, Song BL, Rawson RB, Debose-Boyd RA.

J Biol Chem. 2004 Oct 8;279(41):43136-47. Epub 2004 Jul 7.

PMID:
15247248
[PubMed - indexed for MEDLINE]
Free Article
14.

Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis.

Harris IR, Farrell AM, Holleran WM, Jackson S, Grunfeld C, Elias PM, Feingold KR.

J Lipid Res. 1998 Feb;39(2):412-22.

PMID:
9508001
[PubMed - indexed for MEDLINE]
Free Article
15.

Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding.

Wu N, Sarna LK, Hwang SY, Zhu Q, Wang P, Siow YL, O K.

Biochim Biophys Acta. 2013 Oct;1832(10):1560-8. doi: 10.1016/j.bbadis.2013.04.024. Epub 2013 May 4.

PMID:
23651731
[PubMed - indexed for MEDLINE]
Free Article
16.

Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells.

Ma KL, Varghese Z, Ku Y, Powis SH, Chen Y, Moorhead JF, Ruan XZ.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1646-51. doi: 10.1152/ajpheart.00492.2009. Epub 2010 Mar 26.

PMID:
20348217
[PubMed - indexed for MEDLINE]
Free Article
17.

Insulin-induced gene: a new regulator in lipid metabolism.

Dong XY, Tang SQ.

Peptides. 2010 Nov;31(11):2145-50. doi: 10.1016/j.peptides.2010.07.020. Epub 2010 Sep 15. Review.

PMID:
20817058
[PubMed - indexed for MEDLINE]
18.

Overexpression of A-kinase anchoring protein 12A activates sterol regulatory element binding protein-2 and enhances cholesterol efflux in hepatic cells.

Choi MC, Lee YU, Kim SH, Lee JH, Park JH, Streb JW, Oh DY, Im SA, Kim TY, Jong HS, Bang YJ.

Int J Biochem Cell Biol. 2008;40(11):2534-43. doi: 10.1016/j.biocel.2008.04.020. Epub 2008 May 20.

PMID:
18579430
[PubMed - indexed for MEDLINE]
19.

Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription.

Ishitsuka R, Hirabayashi Y, Kobayashi T.

Biochem Biophys Res Commun. 2009 Jan 9;378(2):240-3. doi: 10.1016/j.bbrc.2008.11.030. Epub 2008 Nov 17.

PMID:
19017528
[PubMed - indexed for MEDLINE]
20.

Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells.

Kim B, Park Y, Wegner CJ, Bolling BW, Lee J.

J Nutr Biochem. 2013 Sep;24(9):1564-70. doi: 10.1016/j.jnutbio.2013.01.005. Epub 2013 Mar 18.

PMID:
23517916
[PubMed - indexed for MEDLINE]

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