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Similar articles for PubMed (Select 24332652)

1.

Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A₁ adenosine receptor.

Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Saponaro G, Preti D, Tabrizi MA, Baraldi S, Moorman AR, Vincenzi F, Borea PA, Varani K.

Bioorg Med Chem. 2014 Jan 1;22(1):148-66. doi: 10.1016/j.bmc.2013.11.043. Epub 2013 Dec 1.

PMID:
24332652
2.

Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.

Baraldi PG, Romagnoli R, Pavani MG, Nuñez Mdel C, Tabrizi MA, Shryock JC, Leung E, Moorman AR, Uluoglu C, Iannotta V, Merighi S, Borea PA.

J Med Chem. 2003 Feb 27;46(5):794-809.

PMID:
12593659
3.

Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4-substituted thiophenes as allosteric enhancers of the A1 adenosine receptor.

Romagnoli R, Baraldi PG, Carrion MD, Lopez Cara C, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Moorman AR, Vincenzi F, Borea PA, Varani K.

Eur J Med Chem. 2013 Sep;67:409-27. doi: 10.1016/j.ejmech.2013.07.002. Epub 2013 Jul 13.

PMID:
23911855
4.

Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.

Romagnoli R, Baraldi PG, IJzerman AP, Massink A, Cruz-Lopez O, Lopez-Cara LC, Saponaro G, Preti D, Aghazadeh Tabrizi M, Baraldi S, Moorman AR, Vincenzi F, Borea PA, Varani K.

J Med Chem. 2014 Sep 25;57(18):7673-86. doi: 10.1021/jm5008853. Epub 2014 Sep 12.

PMID:
25181013
5.

Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.

Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Salvador MK, Preti D, Tabrizi MA, Shryock JC, Moorman AR, Vincenzi F, Varani K, Borea PA.

Bioorg Med Chem. 2012 Jan 15;20(2):996-1007. doi: 10.1016/j.bmc.2011.11.044. Epub 2011 Dec 1.

PMID:
22182575
6.

Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.

Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Iaconinoto MA, Preti D, Shryock JC, Moorman AR, Vincenzi F, Varani K, Andrea Borea P.

J Med Chem. 2008 Sep 25;51(18):5875-9. doi: 10.1021/jm800586p. Epub 2008 Aug 26.

PMID:
18729349
7.

2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors.

Tranberg CE, Zickgraf A, Giunta BN, Luetjens H, Figler H, Murphree LJ, Falke R, Fleischer H, Linden J, Scammells PJ, Olsson RA.

J Med Chem. 2002 Jan 17;45(2):382-9.

PMID:
11784142
8.

Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.

Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Salvador MK, Preti D, Tabrizi MA, Moorman AR, Vincenzi F, Borea PA, Varani K.

J Med Chem. 2012 Sep 13;55(17):7719-35. doi: 10.1021/jm3007504. Epub 2012 Aug 28.

PMID:
22889387
9.

Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor.

Baraldi PG, Pavani MG, Shryock JC, Moorman AR, Iannotta V, Borea PA, Romagnoli R.

Eur J Med Chem. 2004 Oct;39(10):855-65.

PMID:
15464619
10.

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

Aurelio L, Christopoulos A, Flynn BL, Scammells PJ, Sexton PM, Valant C.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3704-7. doi: 10.1016/j.bmcl.2011.04.080. Epub 2011 May 4.

PMID:
21612922
11.

2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.

Lütjens H, Zickgraf A, Figler H, Linden J, Olsson RA, Scammells PJ.

J Med Chem. 2003 May 8;46(10):1870-7.

PMID:
12723950
12.

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Valant C, Aurelio L, Devine SM, Ashton TD, White JM, Sexton PM, Christopoulos A, Scammells PJ.

J Med Chem. 2012 Mar 8;55(5):2367-75. doi: 10.1021/jm201600e. Epub 2012 Feb 17.

PMID:
22315963
13.

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ.

Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. Epub 2007 Oct 23.

PMID:
17980606
14.

Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.

Romagnoli R, Baraldi PG, Lopez-Cara C, Cruz-Lopez O, Moorman AR, Massink A, IJzerman AP, Vincenzi F, Borea PA, Varani K.

Eur J Med Chem. 2015 Aug 28;101:185-204. doi: 10.1016/j.ejmech.2015.06.041. Epub 2015 Jun 24.

PMID:
26141910
15.

Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor.

Baraldi PG, Zaid AN, Lampronti I, Fruttarolo F, Pavani MG, Tabrizi MA, Shryock JC, Leung E, Romagnoli R.

Bioorg Med Chem Lett. 2000 Sep 4;10(17):1953-7.

PMID:
10987425
16.

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.

Aurelio L, Valant C, Flynn BL, Sexton PM, White JM, Christopoulos A, Scammells PJ.

J Med Chem. 2010 Sep 23;53(18):6550-9. doi: 10.1021/jm1008538.

PMID:
20806896
17.

Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.

Baraldi PG, Pavani MG, Leung E, Moorman AR, Varani K, Vincenzi F, Borea PA, Romagnoli R.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1402-4.

PMID:
16321527
18.

Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.

Baraldi PG, Fruttarolo F, Tabrizi MA, Preti D, Romagnoli R, El-Kashef H, Moorman A, Varani K, Gessi S, Merighi S, Borea PA.

J Med Chem. 2003 Mar 27;46(7):1229-41.

PMID:
12646033
20.

[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.

Varani K, Merighi S, Gessi S, Klotz KN, Leung E, Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Borea PA.

Mol Pharmacol. 2000 May;57(5):968-75.

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