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24331535,25834401,25834400,25609923,18361842,25632222,25792811,28524116,27494886,28197628,28745544,29024631,25632225,28355296,25733818,27756877,29788929,29360689,31255635,24534837,25767376,27114702,27815218,23067223,17050787,25788264,26313911,20862710,27602962,32544818,30096805,17623090,32454290,33627540,33885818,30132535,31340526,17007924,27261572,21331075,33223507,27243769,20946021,28582759,26420965,29510199,28364098,12242656,27491646,22614243,27889779,16818631,23546866,27176794,30874538,26573768,27484210,19699753,24044882,26619207,23000445,27285995,27363949,24907655,31830480,22339676,22260024,31023529,29866060,23859040,32098126,31707337,28435223,17172425,33116405,24053190,21277936,25619389,17148679,20504360,29770446,31421117,20133117,28623712,23984518,27989873,19827268,29289836,27644244,30464525,27177156,23172666,23038273,21083937,27823618,27107742,28386317,32594094,23076967,29974191,26311737,15950964,26530632,30896824,33627124,27838742,31276230,33891090,21081844,22029423,23314035,24597985,34753517,25936406,26277504,28251795,21964343,27527160,19566920,28900281,28926094,29071538,29263493,27068641,25619392,30890503,25571712,32731544,29658576,29377384,29533017,34435521,28983625,27002406,27416805,31081049,29655701,30610801,19538862,30613017,19959541,33011370,29762880,28092744,14749477,23892718,32106366,24304514,32084644,21695150,22938451,32155920,27914215,30122899,30536541,31894502,36334389,21179458,23532091,29145153,34328830,30015913,33675913,32630532,21928294,16731767,29262896,29197358,29244196,29207060,31460901,34796518,22874569,21878661,25778879,23974517,33017635,29496173,27104510,28931215,25132339,30050147,23721513,33015162,24735948,29578162,32231197,29556372,25050564,21980390,31387191,26645893,29620273,33860036,29879712,16546976,31412263,29663499,35697119,29808793,29699632,29433680,30873870,36495764,29891445,17457054,21181363,31827702,27196001,30468278,26969377,21367753,25196016,26078792,35049439,29966607,22644961,29022891,23272906,32597573,21279332,28214861,32034768,30372822,28950914,31464618,16761963,36544104,29655686,29620175,26969378,25088259,30244168,17868649,33744322,34490484,30536730,22218562,32009115,29665899,30702500,29990873,30196309,29115429,18793585,29992400,20844237,28302032,25543478,22178132,30056610,29504068,33602509,30666790,32922198,25116358,28385009,30287338,18347188,25596736,31301225,30393233,23541682,29049987,32415699,31295040,33921647,33026807,18826146,24267781,26891668,35226448,19471092,24241349,23866663,23088850,30488428,29050670,31006841,18928588,31418365,21566064,34499759,28376477,28160858,20543569,27160160,21984149,25336146,28854420,33706141,20972827,29070114,25750308,29082697,31762815,19108833,34044254,25146681,18421301,34592338,26434860,33912959,28945040,22078465,36826047,31661890,24359639,28359054,30370525,32149078,34224698,31042587,19121316,35959422,26913385,29723857,30535452,30954890,24260465,22242130,28243129,28922542,30027566,29468753,16624738,25543484,36838737,29017179,30502647,30785478,31610157,34080021,35249489,31726078,30844702,34572904,23089471,32468000,30738116,30194165,29735437,30991714,26356261,22876687,22552626,24552990,33390784,35680808,30247801,27115866,17236628,32867814,23349934,26212201,25967874,29950218,30555320,16141350,20697841,23370361,30191969,22773373,32036474,29780826,23372833,33793811,25985565,31962201,29235249,30006194,25684472,31905252,22490804,34736000,11693548,23158190,31734597,35421676,19246562,27694919,32800789,23359184,35045655,32540572,23329343,32197645,33142533,28713151,25034786,30246034,28940036,21887223,25641147,31955628,29434833,21897118,33628104,32547320,35894200,30884307,12632486,14744787,29242151,31217869,34750375,27671480,29286920,35428493,19063842,20576128,36476885,33649826,26619367,19164894,18286288,32895159,27941168,28641627,23190603,24606425,20401667,16928824,26067645,32820611,30394307,19885574,30387805,16864087,26223914,31322190,23161277,29393406,18060622,16209266,29916532,12689943,27429588,29434742,36500361,30069694,35387632,35769815,24077634,10848832,27531814,30413092,23201404,28499732,29775899,32879652,22001647,30269036,33038921,35416174,29428665,34733370,29048676,30015872,32190974,35947289,35238458,31749427,26477823,30018246,30387825,17804729,32913402,29179029,24304568,29670377,29084921,25297117,19549761,28349379,32788939,29490645,19372630,29949919,33527009,26303320,22903412,12148909,33149614,18849663,32466337,20424615,22659796,29334671,26331691,30988770,35981361,12628512,34758822,36923503,29561956,27538132,35331093,25226616,25169550,24613413,29956395,36651538,31068282,24710924,21407133,28537658,28703366,30660475,31456160,32945501,29484762,20074931,12151351,28112581,31780944,32259210,22249159,11163107,34913075,30132966,15188005,29039784,29780409,26806743,29994802,26633711,33456359,30610811,34669780,36765481,25083993,28007775,24985178,27591926,32818521,32308415,24932295,22417066,36262053,25502636,21993664,36029643,16494014,29483777,36356720,34968999,29355493,18473178,16445836,35259610,32265105,33380391,34093198,19909554,17569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Results by year

Year	Number of Results
2000	2
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2003	6
2004	4
2005	6
2006	18
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2008	16
2009	22
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2018	151
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2024	0

933 results

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Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK.

Ge J, Liu Y, Li Q, Guo X, Gu L, Ma ZG, Zhu YP. Ge J, et al. Biomed Environ Sci. 2013 Nov;26(11):902-11. doi: 10.3967/bes2013.019. Biomed Environ Sci. 2013. PMID: 24331535 Free article.

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.

Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX, Zhou SF. Li JP, et al. Drug Des Devel Ther. 2015 Mar 16;9:1627-52. doi: 10.2147/DDDT.S75378. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25834401 Free PMC article.

Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells.

Pan ST, Qin Y, Zhou ZW, He ZX, Zhang X, Yang T, Yang YX, Wang D, Qiu JX, Zhou SF. Pan ST, et al. Drug Des Devel Ther. 2015 Mar 16;9:1601-26. doi: 10.2147/DDDT.S76057. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25834400 Free PMC article.

Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells.

Yuan CX, Zhou ZW, Yang YX, He ZX, Zhang X, Wang D, Yang T, Wang NJ, Zhao RJ, Zhou SF. Yuan CX, et al. Drug Des Devel Ther. 2015 Jan 14;9:487-508. doi: 10.2147/DDDT.S74127. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25609923 Free PMC article.

[The role of mitogen-activated protein kinase cascades in inhibition of proliferation in human prostate carcinoma cells by raloxifene: an in vitro experiment].

Zhang YX, Kong CZ. Zhang YX, et al. Zhonghua Yi Xue Za Zhi. 2008 Jan 22;88(4):271-5. Zhonghua Yi Xue Za Zhi. 2008. PMID: 18361842 Chinese.

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells.

Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF. Wang F, et al. Drug Des Devel Ther. 2015 Jan 17;9:537-60. doi: 10.2147/DDDT.S73689. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25632222 Free PMC article.

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Niu NK, Wang ZL, Pan ST, Ding HQ, Au GH, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF. Niu NK, et al. Drug Des Devel Ther. 2015 Mar 12;9:1555-84. doi: 10.2147/DDDT.S74197. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 25792811 Free PMC article.

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells.

Kim KY, Park KI, Kim SH, Yu SN, Park SG, Kim YW, Seo YK, Ma JY, Ahn SC. Kim KY, et al. Int J Mol Sci. 2017 May 18;18(5):1088. doi: 10.3390/ijms18051088. Int J Mol Sci. 2017. PMID: 28524116 Free PMC article.

Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia.

Alameen AA, Simioni C, Martelli AM, Zauli G, Ultimo S, McCubrey JA, Gonelli A, Marisi G, Ulivi P, Capitani S, Neri LM. Alameen AA, et al. Oncotarget. 2016 Aug 23;7(34):55690-55703. doi: 10.18632/oncotarget.10984. Oncotarget. 2016. PMID: 27494886 Free PMC article.

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling.

Chang CH, Lee CY, Lu CC, Tsai FJ, Hsu YM, Tsao JW, Juan YN, Chiu HY, Yang JS, Wang CC. Chang CH, et al. Int J Oncol. 2017 Mar;50(3):873-882. doi: 10.3892/ijo.2017.3866. Epub 2017 Jan 30. Int J Oncol. 2017. PMID: 28197628

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