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Results: 1 to 20 of 104

1.

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.

Janovick JA, Stewart MD, Jacob D, Martin LD, Deng JM, Stewart CA, Wang Y, Cornea A, Chavali L, Lopez S, Mitalipov S, Kang E, Lee HS, Manna PR, Stocco DM, Behringer RR, Conn PM.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21030-5. doi: 10.1073/pnas.1315194110. Epub 2013 Dec 9.

PMID:
24324164
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure.

Stewart MD, Deng JM, Stewart CA, Mullen RD, Wang Y, Lopez S, Serna MK, Huang CC, Janovick JA, Pask AJ, Schwartz RJ, Conn PM, Behringer RR.

Mol Endocrinol. 2012 Nov;26(11):1847-56. doi: 10.1210/me.2012-1072. Epub 2012 Aug 23.

PMID:
22918878
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Drug development and the cellular quality control system.

Conn PM, Janovick JA.

Trends Pharmacol Sci. 2009 May;30(5):228-33. doi: 10.1016/j.tips.2009.02.002. Epub 2009 Mar 21. Review.

PMID:
19307028
[PubMed - indexed for MEDLINE]
4.

A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.

Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR.

Mol Endocrinol. 2005 Apr;19(4):972-81. Epub 2004 Dec 29.

PMID:
15625238
[PubMed - indexed for MEDLINE]
5.

Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking.

Janovick JA, Conn PM.

Methods Enzymol. 2010;485:277-92. doi: 10.1016/B978-0-12-381296-4.00016-6.

PMID:
21050923
[PubMed - indexed for MEDLINE]
6.

Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease.

Conn PM, Janovick JA.

Mol Cell Endocrinol. 2009 Feb 27;299(2):137-45. doi: 10.1016/j.mce.2008.10.051. Epub 2008 Nov 18. Review.

PMID:
19059461
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs.

Janovick JA, Park BS, Conn PM.

PLoS One. 2011;6(7):e22784. doi: 10.1371/journal.pone.0022784. Epub 2011 Jul 27.

PMID:
21818389
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro.

Janovick JA, Brothers SP, Cornea A, Bush E, Goulet MT, Ashton WT, Sauer DR, Haviv F, Greer J, Conn PM.

Mol Cell Endocrinol. 2007 Jun 30;272(1-2):77-85. Epub 2007 May 3.

PMID:
17555869
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.

Conn PM, Ulloa-Aguirre A.

Trends Endocrinol Metab. 2010 Mar;21(3):190-7. doi: 10.1016/j.tem.2009.11.003. Epub 2009 Dec 11. Review.

PMID:
20005736
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors.

Ulloa-Aguirre A, Michael Conn P.

Recent Pat Endocr Metab Immune Drug Discov. 2011 Jan;5(1):13-24. Review.

PMID:
22074574
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism.

Leaños-Miranda A, Janovick JA, Conn PM.

J Clin Endocrinol Metab. 2002 Oct;87(10):4825-8.

PMID:
12364481
[PubMed - indexed for MEDLINE]
12.

Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target.

Maya-Núñez G, Ulloa-Aguirre A, Janovick JA, Conn PM.

Subcell Biochem. 2012;63:263-89. doi: 10.1007/978-94-007-4765-4_14. Review.

PMID:
23161143
[PubMed - indexed for MEDLINE]
13.

G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo.

Conn PM, Ulloa-Aguirre A, Ito J, Janovick JA.

Pharmacol Rev. 2007 Sep;59(3):225-50. Review.

PMID:
17878512
[PubMed - indexed for MEDLINE]
Free Article
14.

In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles.

Leaños-Miranda A, Ulloa-Aguirre A, Janovick JA, Conn PM.

J Clin Endocrinol Metab. 2005 May;90(5):3001-8. Epub 2005 Feb 22.

PMID:
15728205
[PubMed - indexed for MEDLINE]
15.

Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance.

Ulloa-Aguirre A, Janovick JA, Leaños-Miranda A, Conn PM.

Expert Opin Ther Targets. 2003 Apr;7(2):175-85. Review.

PMID:
12667096
[PubMed - indexed for MEDLINE]
16.
17.

Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism.

Maya-Núñez G, Janovick JA, Aguilar-Rojas A, Jardón-Valadez E, Leaños-Miranda A, Zariñan T, Ulloa-Aguirre A, Conn PM.

Mol Cell Endocrinol. 2011 Apr 30;337(1-2):16-23. doi: 10.1016/j.mce.2011.01.016. Epub 2011 Jan 26.

PMID:
21277937
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect.

Brothers SP, Cornea A, Janovick JA, Conn PM.

Mol Endocrinol. 2004 Jul;18(7):1787-97. Epub 2004 Apr 22.

PMID:
15105440
[PubMed - indexed for MEDLINE]
19.

Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function.

Bédécarrats GY, Kaiser UB.

Semin Reprod Med. 2007 Sep;25(5):368-78. Review.

PMID:
17710733
[PubMed - indexed for MEDLINE]
20.

GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone.

Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS Jr, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF Jr, Kaiser UB.

J Clin Endocrinol Metab. 2004 Jul;89(7):3189-98.

PMID:
15240592
[PubMed - indexed for MEDLINE]

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