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Results: 1 to 20 of 98

1.

GPR120 agonism as a countermeasure against metabolic diseases.

Cornall LM, Mathai ML, Hryciw DH, McAinch AJ.

Drug Discov Today. 2014 May;19(5):670-9. doi: 10.1016/j.drudis.2013.11.021. Epub 2013 Dec 4.

PMID:
24315954
[PubMed - in process]
2.

Potential roles of GPR120 and its agonists in the management of diabetes.

Zhang D, Leung PS.

Drug Des Devel Ther. 2014 Jul 29;8:1013-1027. eCollection 2014. Review.

PMID:
25114508
[PubMed - as supplied by publisher]
Free PMC Article
3.

Regulation of Energy Homeostasis via GPR120.

Ichimura A, Hara T, Hirasawa A.

Front Endocrinol (Lausanne). 2014 Jul 11;5:111. doi: 10.3389/fendo.2014.00111. eCollection 2014. Review.

PMID:
25071726
[PubMed]
Free PMC Article
4.

Free fatty acid receptor GPR120 and pathogenesis of obesity and type 2 diabetes mellitus.

Mo XL, Wei HK, Peng J, Tao YX.

Prog Mol Biol Transl Sci. 2013;114:251-76. doi: 10.1016/B978-0-12-386933-3.00007-8. Review.

PMID:
23317787
[PubMed - indexed for MEDLINE]
5.

Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons.

Wellhauser L, Belsham DD.

J Neuroinflammation. 2014 Mar 27;11:60. doi: 10.1186/1742-2094-11-60.

PMID:
24674717
[PubMed - in process]
Free PMC Article
6.

Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders.

Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G.

J Pharm Sci. 2011 Sep;100(9):3594-601. doi: 10.1002/jps.22639. Epub 2011 May 25. Review.

PMID:
21618241
[PubMed - indexed for MEDLINE]
7.

Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor.

Burns RN, Moniri NH.

Biochem Biophys Res Commun. 2010 Jun 11;396(4):1030-5. doi: 10.1016/j.bbrc.2010.05.057. Epub 2010 May 13.

PMID:
20471368
[PubMed - indexed for MEDLINE]
8.

CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.

Ozdener MH, Subramaniam S, Sundaresan S, Sery O, Hashimoto T, Asakawa Y, Besnard P, Abumrad NA, Khan NA.

Gastroenterology. 2014 Apr;146(4):995-1005. doi: 10.1053/j.gastro.2014.01.006. Epub 2014 Jan 9.

PMID:
24412488
[PubMed - indexed for MEDLINE]
9.

Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.

Holliday ND, Watson SJ, Brown AJ.

Front Endocrinol (Lausanne). 2012 Jan 3;2:112. doi: 10.3389/fendo.2011.00112. eCollection 2011.

PMID:
22649399
[PubMed]
Free PMC Article
10.

Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice.

Godinot N, Yasumatsu K, Barcos ME, Pineau N, Ledda M, Viton F, Ninomiya Y, le Coutre J, Damak S.

Neuroscience. 2013 Oct 10;250:20-30. doi: 10.1016/j.neuroscience.2013.06.043. Epub 2013 Jul 4.

PMID:
23831422
[PubMed - indexed for MEDLINE]
11.

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.

Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P.

Nature. 2012 Feb 19;483(7389):350-4. doi: 10.1038/nature10798.

PMID:
22343897
[PubMed - indexed for MEDLINE]
12.

Is GPR119 agonism an appropriate treatment modality for the safe amelioration of metabolic diseases?

Cornall LM, Mathai ML, Hryciw DH, McAinch AJ.

Expert Opin Investig Drugs. 2013 Apr;22(4):487-98. doi: 10.1517/13543784.2013.775245. Epub 2013 Feb 27. Review.

PMID:
23442069
[PubMed - indexed for MEDLINE]
13.

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases.

Talukdar S, Olefsky JM, Osborn O.

Trends Pharmacol Sci. 2011 Sep;32(9):543-50. doi: 10.1016/j.tips.2011.04.004. Epub 2011 Jun 12. Review.

PMID:
21663979
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.

Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG.

Diabetologia. 2014 Jun;57(6):1182-91. doi: 10.1007/s00125-014-3213-0. Epub 2014 Mar 25.

PMID:
24663807
[PubMed - in process]
Free PMC Article
15.

GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders.

Shah U, Kowalski TJ.

Vitam Horm. 2010;84:415-48. doi: 10.1016/B978-0-12-381517-0.00016-3. Review.

PMID:
21094910
[PubMed - indexed for MEDLINE]
16.

Discovery of a potent and selective GPR120 agonist.

Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T.

J Med Chem. 2012 May 10;55(9):4511-5. doi: 10.1021/jm300215x. Epub 2012 May 2.

PMID:
22519963
[PubMed - indexed for MEDLINE]
17.

The therapeutic potential of GPR43: a novel role in modulating metabolic health.

Cornall LM, Mathai ML, Hryciw DH, McAinch AJ.

Cell Mol Life Sci. 2013 Dec;70(24):4759-70. doi: 10.1007/s00018-013-1419-9. Epub 2013 Jul 14. Review.

PMID:
23852543
[PubMed - indexed for MEDLINE]
18.

Cardiovascular comorbidities of type 2 diabetes mellitus: defining the potential of glucagonlike peptide-1-based therapies.

Chilton R, Wyatt J, Nandish S, Oliveros R, Lujan M.

Am J Med. 2011 Jan;124(1 Suppl):S35-53. doi: 10.1016/j.amjmed.2010.11.004. Review.

PMID:
21194579
[PubMed - indexed for MEDLINE]
19.

The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference.

Martin C, Passilly-Degrace P, Gaillard D, Merlin JF, Chevrot M, Besnard P.

PLoS One. 2011;6(8):e24014. doi: 10.1371/journal.pone.0024014. Epub 2011 Aug 25.

PMID:
21901153
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

[Diet-induced obesity and GPR120].

Ichimura A.

Nihon Rinsho. 2013 Feb;71(2):350-4. Review. Japanese.

PMID:
23631220
[PubMed - indexed for MEDLINE]

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