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Items: 1 to 20 of 318

1.

Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.

Yang SJ, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY.

J Nutr Biochem. 2014 Jan;25(1):66-72. doi: 10.1016/j.jnutbio.2013.09.004. Epub 2013 Oct 10.

PMID:
24314867
2.

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.

Li H, Xu M, Lee J, He C, Xie Z.

Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1234-44. doi: 10.1152/ajpendo.00198.2012. Epub 2012 Sep 11.

3.

Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice.

Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, Hirata Y, Kurobe H, Maeda N, Sakaue H, Masuzaki H, Shimomura I, Sata M.

Cardiovasc Diabetol. 2012 Nov 8;11:139. doi: 10.1186/1475-2840-11-139.

4.

Metabolic benefits from Sirt1 and Sirt1 activators.

Chaudhary N, Pfluger PT.

Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):431-7. doi: 10.1097/MCO.0b013e32832cdaae. Review.

PMID:
19474719
5.

Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth.

Gu C, Zeng Y, Tang Z, Wang C, He Y, Feng X, Zhou L.

Mol Med Rep. 2015 Nov;12(5):6451-60. doi: 10.3892/mmr.2015.4245. Epub 2015 Aug 25.

6.

SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis.

Shin SY, Kim TH, Wu H, Choi YH, Kim SG.

Eur J Pharmacol. 2014 Mar 15;727:115-24. doi: 10.1016/j.ejphar.2014.01.035. Epub 2014 Jan 30.

PMID:
24486702
7.

Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects.

Wang X, Liu R, Zhang W, Zhang X, Liao N, Wang Z, Li W, Qin X, Hai C.

Mol Cell Endocrinol. 2013 Aug 25;376(1-2):70-80. doi: 10.1016/j.mce.2013.06.014. Epub 2013 Jun 18.

PMID:
23791844
8.

NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response.

Liu TF, Vachharajani VT, Yoza BK, McCall CE.

J Biol Chem. 2012 Jul 27;287(31):25758-69. doi: 10.1074/jbc.M112.362343. Epub 2012 Jun 14.

9.

WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis.

Wu J, Zhang F, Yan M, Wu D, Yu Q, Zhang Y, Zhou B, McBurney MW, Zhai Q.

Diabetes. 2011 Dec;60(12):3197-207. doi: 10.2337/db11-0232. Epub 2011 Oct 13.

10.

Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PPARalpha in mice.

Hayashida S, Arimoto A, Kuramoto Y, Kozako T, Honda S, Shimeno H, Soeda S.

Mol Cell Biochem. 2010 Jun;339(1-2):285-92. doi: 10.1007/s11010-010-0391-z. Epub 2010 Feb 11.

PMID:
20148352
11.

Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.

Zhang ZF, Fan SH, Zheng YL, Lu J, Wu DM, Shan Q, Hu B.

Biochem Pharmacol. 2014 Sep 1;91(1):74-86. doi: 10.1016/j.bcp.2014.07.002. Epub 2014 Jul 12.

PMID:
25026599
12.

Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells.

Yang NC, Song TY, Chang YZ, Chen MY, Hu ML.

Biogerontology. 2015 Feb;16(1):31-42. doi: 10.1007/s10522-014-9528-x. Epub 2014 Aug 22.

PMID:
25146190
13.

Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT.

Choi SE, Fu T, Seok S, Kim DH, Yu E, Lee KW, Kang Y, Li X, Kemper B, Kemper JK.

Aging Cell. 2013 Dec;12(6):1062-72. doi: 10.1111/acel.12135. Epub 2013 Aug 11.

14.

Light-dark condition regulates sirtuin mRNA levels in the retina.

Ban N, Ozawa Y, Inaba T, Miyake S, Watanabe M, Shinmura K, Tsubota K.

Exp Gerontol. 2013 Nov;48(11):1212-7. doi: 10.1016/j.exger.2013.04.010. Epub 2013 May 3.

15.

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Yoshino J, Mills KF, Yoon MJ, Imai S.

Cell Metab. 2011 Oct 5;14(4):528-36. doi: 10.1016/j.cmet.2011.08.014.

16.

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.

Côté CD, Rasmussen BA, Duca FA, Zadeh-Tahmasebi M, Baur JA, Daljeet M, Breen DM, Filippi BM, Lam TK.

Nat Med. 2015 May;21(5):498-505. doi: 10.1038/nm.3821. Epub 2015 Apr 6.

PMID:
25849131
17.

Weight Loss Is Associated With Increased NAD(+)/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue.

Rappou E, Jukarainen S, Rinnankoski-Tuikka R, Kaye S, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saunavaara V, Rissanen A, Virtanen KA, Pirinen E, Pietiläinen KH.

J Clin Endocrinol Metab. 2016 Mar;101(3):1263-73. doi: 10.1210/jc.2015-3054. Epub 2016 Jan 13.

PMID:
26760174
19.

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.

Fu L, Bruckbauer A, Li F, Cao Q, Cui X, Wu R, Shi H, Zemel MB, Xue B.

Metabolism. 2015 Jul;64(7):845-56. doi: 10.1016/j.metabol.2015.03.007. Epub 2015 Mar 19.

PMID:
25858853
20.

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.

Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93. doi: 10.1073/pnas.0812931106. Epub 2009 Jun 22.

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