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Items: 1 to 20 of 283

1.

Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.

Stachel I, Geismann C, Aden K, Deisinger F, Rosenstiel P, Schreiber S, Sebens S, Arlt A, Schäfer H.

J Biol Chem. 2014 Jan 24;289(4):1917-29. doi: 10.1074/jbc.M113.490920. Epub 2013 Dec 5.

2.

PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells.

Deng X, Rui W, Zhang F, Ding W.

Cell Biol Toxicol. 2013 Jun;29(3):143-57. doi: 10.1007/s10565-013-9242-5. Epub 2013 Mar 24.

PMID:
23525690
3.

Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection.

Sebens S, Bauer I, Geismann C, Grage-Griebenow E, Ehlers S, Kruse ML, Arlt A, Schäfer H.

J Biol Chem. 2011 Nov 25;286(47):40911-21. doi: 10.1074/jbc.M111.274902. Epub 2011 Oct 11.

4.
5.

Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling.

Wu J, Xu H, Wong PF, Xia S, Xu J, Dong J.

Food Chem Toxicol. 2014 Feb;64:307-13. doi: 10.1016/j.fct.2013.12.006. Epub 2013 Dec 8.

PMID:
24333105
6.

Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells.

Xu Y, Duan C, Kuang Z, Hao Y, Jeffries JL, Lau GW.

PLoS One. 2013 Aug 27;8(8):e72528. doi: 10.1371/journal.pone.0072528. eCollection 2013.

7.

Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.

Almazari I, Park JM, Park SA, Suh JY, Na HK, Cha YN, Surh YJ.

Carcinogenesis. 2012 Feb;33(2):368-76. doi: 10.1093/carcin/bgr259. Epub 2011 Nov 17.

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9.

Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment.

Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, Kensler TW.

Int J Cancer. 2007 Nov 1;121(9):1883-91.

10.

Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells.

Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C.

J Biol Chem. 2011 Feb 25;286(8):6092-9. doi: 10.1074/jbc.M110.192534. Epub 2011 Jan 6.

11.

The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells.

Ci X, Lv H, Wang L, Wang X, Peng L, Qin FX, Cheng G.

Chem Biol Interact. 2015 Sep 5;239:192-9. doi: 10.1016/j.cbi.2015.06.032. Epub 2015 Jun 22.

PMID:
26111761
12.

Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.

Li Z, Dong X, Liu H, Chen X, Shi H, Fan Y, Hou D, Zhang X.

Mol Vis. 2013 Jul 25;19:1656-66. Print 2013.

13.

EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.

Papaiahgari S, Yerrapureddy A, Hassoun PM, Garcia JG, Birukov KG, Reddy SP.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):304-12. Epub 2006 Sep 28.

14.

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells.

Hsu YY, Chen CS, Wu SN, Jong YJ, Lo YC.

Eur J Pharm Sci. 2012 Aug 15;46(5):415-25. doi: 10.1016/j.ejps.2012.03.004. Epub 2012 Mar 24.

PMID:
22469516
16.

Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice.

Theiss AL, Vijay-Kumar M, Obertone TS, Jones DP, Hansen JM, Gewirtz AT, Merlin D, Sitaraman SV.

Gastroenterology. 2009 Jul;137(1):199-208, 208.e1-6. doi: 10.1053/j.gastro.2009.03.033. Epub 2009 Mar 25.

17.

Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis.

Kathiria AS, Butcher MA, Hansen JM, Theiss AL.

Am J Physiol Gastrointest Liver Physiol. 2013 May 15;304(10):G885-96. doi: 10.1152/ajpgi.00327.2012. Epub 2013 Mar 14.

18.

Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins.

Kim SJ, Park C, Lee JN, Lim H, Hong GY, Moon SK, Lim DJ, Choe SK, Park R.

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):192-202. doi: 10.1016/j.taap.2015.07.014. Epub 2015 Jul 18.

PMID:
26193055
19.

15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes.

Lee E, Yin Z, Sidoryk-Węgrzynowicz M, Jiang H, Aschner M.

Free Radic Biol Med. 2012 Mar 15;52(6):1067-74. doi: 10.1016/j.freeradbiomed.2011.12.016. Epub 2011 Dec 29.

20.

Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE.

Wang L, Chen Y, Sternberg P, Cai J.

Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1671-8. doi: 10.1167/iovs.07-1099.

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