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Results: 1 to 20 of 106

1.

Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis.

Rao SP, Lakshminarayana SB, Kondreddi RR, Herve M, Camacho LR, Bifani P, Kalapala SK, Jiricek J, Ma NL, Tan BH, Ng SH, Nanjundappa M, Ravindran S, Seah PG, Thayalan P, Lim SH, Lee BH, Goh A, Barnes WS, Chen Z, Gagaring K, Chatterjee AK, Pethe K, Kuhen K, Walker J, Feng G, Babu S, Zhang L, Blasco F, Beer D, Weaver M, Dartois V, Glynne R, Dick T, Smith PW, Diagana TT, Manjunatha UH.

Sci Transl Med. 2013 Dec 4;5(214):214ra168. doi: 10.1126/scitranslmed.3007355.

PMID:
24307692
[PubMed - indexed for MEDLINE]
2.

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.

Remuiñán MJ, Pérez-Herrán E, Rullás J, Alemparte C, Martínez-Hoyos M, Dow DJ, Afari J, Mehta N, Esquivias J, Jiménez E, Ortega-Muro F, Fraile-Gabaldón MT, Spivey VL, Loman NJ, Pallen MJ, Constantinidou C, Minick DJ, Cacho M, Rebollo-López MJ, González C, Sousa V, Angulo-Barturen I, Mendoza-Losana A, Barros D, Besra GS, Ballell L, Cammack N.

PLoS One. 2013 Apr 17;8(4):e60933. doi: 10.1371/journal.pone.0060933. Print 2013.

PMID:
23613759
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.

Hameed P S, Patil V, Solapure S, Sharma U, Madhavapeddi P, Raichurkar A, Chinnapattu M, Manjrekar P, Shanbhag G, Puttur J, Shinde V, Menasinakai S, Rudrapatana S, Achar V, Awasthy D, Nandishaiah R, Humnabadkar V, Ghosh A, Narayan C, Ramya VK, Kaur P, Sharma S, Werngren J, Hoffner S, Panduga V, Kumar CN, Reddy J, Kumar K N M, Ganguly S, Bharath S, Bheemarao U, Mukherjee K, Arora U, Gaonkar S, Coulson M, Waterson D, Sambandamurthy VK, de Sousa SM.

J Med Chem. 2014 Jun 12;57(11):4889-905. doi: 10.1021/jm500432n. Epub 2014 May 23.

PMID:
24809953
[PubMed - indexed for MEDLINE]
4.

Indoleamides are active against drug-resistant Mycobacterium tuberculosis.

Lun S, Guo H, Onajole OK, Pieroni M, Gunosewoyo H, Chen G, Tipparaju SK, Ammerman NC, Kozikowski AP, Bishai WR.

Nat Commun. 2013;4:2907. doi: 10.1038/ncomms3907.

PMID:
24352433
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
[PubMed - indexed for MEDLINE]
6.

Genotypes and drug susceptibility of Mycobacterium tuberculosis Isolates in Shihezi, Xinjiang Province, China.

Zhang J, Mi L, Wang Y, Liu P, Liang H, Huang Y, Lv B, Yuan L.

BMC Res Notes. 2012 Jun 19;5:309. doi: 10.1186/1756-0500-5-309.

PMID:
22713520
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.

Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N, Reddy J, Panduga V, Sharma S, Ambady A, Hegde N, Whiteaker J, McLaughlin RE, Gardner H, Madhavapeddi P, Ramachandran V, Kaur P, Narayan A, Guptha S, Awasthy D, Narayan C, Mahadevaswamy J, Vishwas KG, Ahuja V, Srivastava A, Prabhakar KR, Bharath S, Kale R, Ramaiah M, Choudhury NR, Sambandamurthy VK, Solapure S, Iyer PS, Narayanan S, Chatterji M.

J Med Chem. 2013 Dec 12;56(23):9701-8. doi: 10.1021/jm401382v. Epub 2013 Nov 21.

PMID:
24215368
[PubMed - indexed for MEDLINE]
8.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.

Villar R, Vicente E, Solano B, Pérez-Silanes S, Aldana I, Maddry JA, Lenaerts AJ, Franzblau SG, Cho SH, Monge A, Goldman RC.

J Antimicrob Chemother. 2008 Sep;62(3):547-54. doi: 10.1093/jac/dkn214. Epub 2008 May 23.

PMID:
18502817
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

In vitro and in vivo activities of a new lead compound I2906 against Mycobacterium tuberculosis.

Lu J, Yue J, Wu J, Luo R, Hu Z, Li J, Bai Y, Tang Z, Xian Q, Zhang X, Wang H.

Pharmacology. 2010;85(6):365-71. doi: 10.1159/000299795. Epub 2010 Jun 8.

PMID:
20530976
[PubMed - indexed for MEDLINE]
10.

[Frontier of mycobacterium research--host vs. mycobacterium].

Okada M, Shirakawa T.

Kekkaku. 2005 Sep;80(9):613-29. Japanese.

PMID:
16245793
[PubMed - indexed for MEDLINE]
11.

Genetic polymorphism in Mycobacterium tuberculosis isolates from patients with chronic multidrug-resistant tuberculosis.

Post FA, Willcox PA, Mathema B, Steyn LM, Shean K, Ramaswamy SV, Graviss EA, Shashkina E, Kreiswirth BN, Kaplan G.

J Infect Dis. 2004 Jul 1;190(1):99-106. Epub 2004 May 28.

PMID:
15195248
[PubMed - indexed for MEDLINE]
Free Article
12.

Consequences of noncompliance for therapy efficacy and emergence of resistance in murine tuberculosis caused by the Beijing genotype of Mycobacterium tuberculosis.

de Steenwinkel JE, ten Kate MT, de Knegt GJ, Verbrugh HA, Aarnoutse RE, Boeree MJ, den Bakker MA, van Soolingen D, Bakker-Woudenberg IA.

Antimicrob Agents Chemother. 2012 Sep;56(9):4937-44. doi: 10.1128/AAC.00124-12. Epub 2012 Jul 16.

PMID:
22802244
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki K.

Antimicrob Agents Chemother. 2012 Aug;56(8):4140-5. doi: 10.1128/AAC.06445-11. Epub 2012 May 21.

PMID:
22615274
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.

Lenaerts AJ, Gruppo V, Marietta KS, Johnson CM, Driscoll DK, Tompkins NM, Rose JD, Reynolds RC, Orme IM.

Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301.

PMID:
15917524
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Antimycobacterial activity of Citrullus colocynthis (L.) Schrad. against drug sensitive and drug resistant Mycobacterium tuberculosis and MOTT clinical isolates.

Mehta A, Srivastva G, Kachhwaha S, Sharma M, Kothari SL.

J Ethnopharmacol. 2013 Aug 26;149(1):195-200. doi: 10.1016/j.jep.2013.06.022. Epub 2013 Jun 29.

PMID:
23816500
[PubMed - indexed for MEDLINE]
16.

Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

Vilchèze C, Baughn AD, Tufariello J, Leung LW, Kuo M, Basler CF, Alland D, Sacchettini JC, Freundlich JS, Jacobs WR Jr.

Antimicrob Agents Chemother. 2011 Aug;55(8):3889-98. doi: 10.1128/AAC.00266-11. Epub 2011 May 31.

PMID:
21628538
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs.

Gupta AK, Katoch VM, Chauhan DS, Sharma R, Singh M, Venkatesan K, Sharma VD.

Microb Drug Resist. 2010 Mar;16(1):21-8. doi: 10.1089/mdr.2009.0054.

PMID:
20001742
[PubMed - indexed for MEDLINE]
18.

The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis.

Müller B, Borrell S, Rose G, Gagneux S.

Trends Genet. 2013 Mar;29(3):160-9. doi: 10.1016/j.tig.2012.11.005. Epub 2012 Dec 13. Review.

PMID:
23245857
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Previous treatment in predicting drug-resistant tuberculosis in an area bordering East London, UK.

Melzer M, Gupta N, Petersen I, Cook S, Hall B.

Int J Infect Dis. 2010 Aug;14(8):e717-22. doi: 10.1016/j.ijid.2010.02.2247. Epub 2010 Jun 12.

PMID:
20542460
[PubMed - indexed for MEDLINE]
Free Article
20.

[Recent progress in mycobacteriology].

Okada M, Kobayashi K.

Kekkaku. 2007 Oct;82(10):783-99. Japanese.

PMID:
18018602
[PubMed - indexed for MEDLINE]

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