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Items: 1 to 20 of 83

1.

Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice.

Trueba-Sáiz A, Cavada C, Fernandez AM, Leon T, González DA, Fortea Ormaechea J, Lleó A, Del Ser T, Nuñez A, Torres-Aleman I.

Transl Psychiatry. 2013 Dec 3;3:e330. doi: 10.1038/tp.2013.102.

2.

Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease.

Johansson P, Åberg D, Johansson JO, Mattsson N, Hansson O, Ahrén B, Isgaard J, Åberg ND, Blennow K, Zetterberg H, Wallin A, Svensson J.

Psychoneuroendocrinology. 2013 Sep;38(9):1729-37. doi: 10.1016/j.psyneuen.2013.02.006. Epub 2013 Mar 6.

PMID:
23473966
3.
5.

Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models.

Zhang B, Tang XC, Zhang HY.

J Neurosci Res. 2013 May;91(5):717-25. doi: 10.1002/jnr.23201. Epub 2013 Feb 12.

PMID:
23401344
7.

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

Carro E, Trejo JL, Spuch C, Bohl D, Heard JM, Torres-Aleman I.

Neurobiol Aging. 2006 Nov;27(11):1618-31. Epub 2005 Nov 7.

PMID:
16274856
8.

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine.

Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM.

J Alzheimers Dis. 2005 Dec;8(3):247-68.

PMID:
16340083
9.

Targeting insulin-like growth factor-1 to treat Alzheimer's disease.

Torres-Aleman I.

Expert Opin Ther Targets. 2007 Dec;11(12):1535-42. Review.

PMID:
18020976
10.

Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease.

Vardy ER, Rice PJ, Bowie PC, Holmes JD, Grant PJ, Hooper NM.

J Alzheimers Dis. 2007 Dec;12(4):285-90.

PMID:
18198415
11.

Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia.

Watanabe T, Miyazaki A, Katagiri T, Yamamoto H, Idei T, Iguchi T.

J Am Geriatr Soc. 2005 Oct;53(10):1748-53.

PMID:
16181175
12.

Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency.

Poirier R, Fernandez AM, Torres-Aleman I, Metzger F.

Neurosci Lett. 2012 Feb 16;509(2):101-4. doi: 10.1016/j.neulet.2011.12.048. Epub 2011 Dec 31.

PMID:
22230888
13.

Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type.

Tham A, Nordberg A, Grissom FE, Carlsson-Skwirut C, Viitanen M, Sara VR.

J Neural Transm Park Dis Dement Sect. 1993;5(3):165-76.

PMID:
7690227
14.

Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.

Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, Schubert M.

FASEB J. 2009 Oct;23(10):3315-24. doi: 10.1096/fj.09-132043. Epub 2009 Jun 1.

15.

Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.

Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB.

Biochem Pharmacol. 2008 Mar 1;75(5):1093-103. Epub 2007 Nov 12.

PMID:
18076866
16.

Possible usefulness of growth hormone/insulin-like growth factor-I axis in Alzheimer's disease treatment.

Sáez JM.

Endocr Metab Immune Disord Drug Targets. 2012 Sep;12(3):274-86. Review.

PMID:
22524398
17.

Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains.

Jafferali S, Dumont Y, Sotty F, Robitaille Y, Quirion R, Kar S.

Synapse. 2000 Dec 15;38(4):450-9.

PMID:
11044892
18.

Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I.

Carro E, Spuch C, Trejo JL, Antequera D, Torres-Aleman I.

J Neurosci. 2005 Nov 23;25(47):10884-93.

19.

Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology.

Kar S, Poirier J, Guevara J, Dea D, Hawkes C, Robitaille Y, Quirion R.

Neurobiol Aging. 2006 Feb;27(2):199-210. Epub 2005 Apr 9.

PMID:
16399207
20.

Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology.

Fernandez AM, Jimenez S, Mecha M, Dávila D, Guaza C, Vitorica J, Torres-Aleman I.

Mol Psychiatry. 2012 Jul;17(7):705-18. doi: 10.1038/mp.2011.128. Epub 2011 Oct 18.

PMID:
22005929
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