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Results: 1 to 20 of 85

1.

SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer.

Gu J, Han T, Ma RH, Zhu YL, Jia YN, Du JJ, Chen Y, Jiang XJ, Xie XD, Guo X.

Int J Oncol. 2014 Feb;44(2):481-90. doi: 10.3892/ijo.2013.2191. Epub 2013 Nov 28.

PMID:
24297342
[PubMed - in process]
2.

The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma.

Jiang C, Hu F, Tai Y, Du J, Mao B, Yuan Z, Wang Y, Wei L.

J Cancer Res Clin Oncol. 2012 Apr;138(4):637-46. doi: 10.1007/s00432-011-1143-5. Epub 2012 Jan 7.

PMID:
22228034
[PubMed - indexed for MEDLINE]
3.

The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.

Agazie YM, Movilla N, Ischenko I, Hayman MJ.

Oncogene. 2003 Oct 9;22(44):6909-18.

PMID:
14534538
[PubMed - indexed for MEDLINE]
4.

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.

Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE, Velculescu VE, Vogelstein B, Meyerson M, Sellers WR, Neel BG.

Cancer Res. 2004 Dec 15;64(24):8816-20.

PMID:
15604238
[PubMed - indexed for MEDLINE]
Free Article
5.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
[PubMed - indexed for MEDLINE]
6.

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.

Schaper F, Gendo C, Eck M, Schmitz J, Grimm C, Anhuf D, Kerr IM, Heinrich PC.

Biochem J. 1998 Nov 1;335 ( Pt 3):557-65.

PMID:
9794795
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.

Zhou XD, Agazie YM.

Cell Death Differ. 2008 Jun;15(6):988-96. doi: 10.1038/cdd.2008.54. Epub 2008 Apr 18.

PMID:
18421299
[PubMed - indexed for MEDLINE]
Free Article
8.

Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma.

Hu Z, Fang H, Wang X, Chen D, Chen Z, Wang S.

Oncol Rep. 2014 Jul;32(1):205-12. doi: 10.3892/or.2014.3201. Epub 2014 May 20.

PMID:
24858400
[PubMed - in process]
9.

Expression and clinical significance of SHP2 in gastric cancer.

Dong S, Li FQ, Zhang Q, Lv KZ, Yang HL, Gao Y, Yu JR.

J Int Med Res. 2012;40(6):2083-9.

PMID:
23321164
[PubMed - indexed for MEDLINE]
10.

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA.

Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7. Review.

PMID:
17126425
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.

Quintanar-Audelo M, Yusoff P, Sinniah S, Chandramouli S, Guy GR.

J Biol Chem. 2011 Jul 1;286(26):23102-12. doi: 10.1074/jbc.M110.212662. Epub 2011 Apr 29.

PMID:
21531714
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

Saxton TM, Ciruna BG, Holmyard D, Kulkarni S, Harpal K, Rossant J, Pawson T.

Nat Genet. 2000 Apr;24(4):420-3.

PMID:
10742110
[PubMed - indexed for MEDLINE]
13.

Regulation of neuregulin-mediated acetylcholine receptor synthesis by protein tyrosine phosphatase SHP2.

Tanowitz M, Si J, Yu DH, Feng GS, Mei L.

J Neurosci. 1999 Nov 1;19(21):9426-35.

PMID:
10531446
[PubMed - indexed for MEDLINE]
Free Article
14.

An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.

Yang W, Klaman LD, Chen B, Araki T, Harada H, Thomas SM, George EL, Neel BG.

Dev Cell. 2006 Mar;10(3):317-27.

PMID:
16516835
[PubMed - indexed for MEDLINE]
Free Article
15.

Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.

De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27.

PMID:
22371576
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells.

McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW.

J Immunol. 2009 Oct 15;183(8):4940-7. doi: 10.4049/jimmunol.0900702. Epub 2009 Sep 28.

PMID:
19786542
[PubMed - indexed for MEDLINE]
Free Article
17.

The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor.

Easton JB, Royer AR, Middlemas DS.

J Neurochem. 2006 May;97(3):834-45. Epub 2006 Mar 29.

PMID:
16573649
[PubMed - indexed for MEDLINE]
18.

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase.

Miura K, Wakayama Y, Tanino M, Orba Y, Sawa H, Hatakeyama M, Tanaka S, Sabe H, Mochizuki N.

Oncogene. 2013 Nov 7;32(45):5292-301. doi: 10.1038/onc.2012.571. Epub 2013 Jan 14.

PMID:
23318428
[PubMed - indexed for MEDLINE]
19.

A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells.

Li L, Modi H, McDonald T, Rossi J, Yee JK, Bhatia R.

Blood. 2011 Aug 11;118(6):1504-15. doi: 10.1182/blood-2010-06-288910. Epub 2011 Jun 13.

PMID:
21670473
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity.

Bae D, Camilli TC, Ha NT, Ceryak S.

Cell Signal. 2009 May;21(5):727-36. doi: 10.1016/j.cellsig.2009.01.011. Epub 2009 Jan 8.

PMID:
19167484
[PubMed - indexed for MEDLINE]
Free PMC Article

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