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24291609,15498883,21693624,23482451,14657005,10741714,24535953,12027461,19944755,17553915,15890193,15663995,7530193,15647825,10218951,26441239,16828283,16807549,26827959,19667147,12900504,9881643,15225811,9366495,34593422,17310066,15585637,16886665,17257827,11576342,11800234,24365583,15867263,21542014,11467853,21911059,26260259,23606409,17029768,15955619,19244278,28578001,8619376,15574355,16280049,9816072,17172823,29110708,15488475,8612485,10347199,24185200,8564982,8137744,29899561,25425001,26654942,10750664,15863722,15225757,16061850,10900137,17213369,12972708,18368131,9295274,10340962,17182978,16549446,17395559,29208972,17426122,10218956,23784946,10496974,16957024,23334593,25305352,27018098,17693608,10218975,6313754,26232635,18501591,26385609,9071474,29367669,26601949,16516540,22982627,16289102,23272223,12899529,26704532,25296887,30031146,22871965,26342089,9017001,22648952,21677063,30893561,32231239,23375797,10731635,10418998,28130182,23059474,15223133,16524720,7673194,20020487,25727742,25644204,11179730,15077124,28860545,24461581,22884583,24587317,29425808,24597546,28465245,9162038,1777040,24245571,25446887,13679056,11012668,22466564,9061605,30200275,9705566,22982757,30205156,28211493,21436386,11508700,24116037,10706413,21715350,23954530,2590383,10694374,24120913,28025137,29488238,24550213,26949105,27977320,21529994,22511602,21697097,9449236,7938037,26124321,15877868,23608137,10399884,28716760,26469137,12041912,10328556,11162893,18726998,12732287,9833978,22841393,6896712,26152509,22174178,16691293,11179749,31696245,18767073,8276112,20564225,7640319,26176830,23869778,36503079,19662683,19097033,27893751,6972531,26367019,17077522,21483824,12175780,8639462,10612418,11179736,30028992,24326417,36191995,27639478,29339180,23155244,20354914,22750718,21307571,23307792,20619365,24643654,12787875,19237542,9799823,23463632,20542050,21424825,24926821,29754009,27530414,30137362,12899519,28591703,23358686,24576880,23850962,23869781,25596923,21664249,10654820,22213328,11179750,25597951,16158254,18205042,10411336,18840526,23941729,24471562,20371703,9366500,12899528,27203211,22940288,20554701,22683670,31945466,19098224,23816829,28673024,19255064,26976974,22068926,28199350,27240300,22454149,10762752,34093587,28257826,33965570,211856,16708384,12431790,20831823,28256614,23041230,12899526,25494645,20236932,21653679,8175775,22710747,31704333,15331405,24486455,35572785,21824271,23674869,16437660,25829051,26586377,2840181,16517748,20527229,31086078,21169243,21669251,8836163,35883516,27923594,22386975,12798352,8760262,17556365,19027855,21610497,11179754,35184385,34980721,16690532,29084783,29753474,22984610,26319202,29393236,16177194,7881807,19779013,29653103,22576141,15320744,31574299,10748178,20460683,26827951,12899524,26291067,28808890,25448747,15758250,27852823,21550403,23142286,34943890,23059472,30978243,16158255,22179019,19169476,26178144,27032903,19414624,20965534,24893882,25914243,10410379,21592821,26433048,34362362,26311239,22989482,19000766,2178322,27428295,19948036,32319119,23992309,21283672,28218743,26214117,30052060,12375732,23087083,28893622,27889974,35911100,27154413,27364341,31734492,28304097,27357804,34394078,25762621,19015318,22751936,27529229,34836354,31868234,26170242,17641030,36142855,22189971,23894780,23036975,32045827,23188491,9316302,31002352,34835929,36014588,31387633,26827954,23454830,20184548,8761938,32441029,30926433,30172168,24081904,26241700,19309155,31665381,23595236,33624437,19863778,25875760,8617997,25811927,22648713,22100522,23153571,20667833,18089708,21635821,28514663,32241530,33900108,29336863,23293122,11524117,11179722,23212742,36567009,26158294,35745177,32498437,19737544,11856765,23119081,18824104,25194637,28187222,8947497,9174267,19454612,2993612,23250517,32485310,10684662,7602383,35560280,25667460,17056796,20440542,19901270,21552398,16886666,22412984,35073416,24391007,12137802,33865853,11384870,12006701,28816551,30802957,10359826,34632483,34948139,25090635,28959253,28179210,23424670,30297679,28039464,22862690,25716812,26501255,28034764,649607,31020705,33037688,35328609,2850225,29186865,6687690,26585929,28216405,3674390,30088172,20070897,26471398,26068789,20878391,24019477,34621269,23965431,22802173,25614971,15225833,34950826,20883026,34959778,23298900,22683847,22564539,22564762,33443406,22133546,26827962,22285938,20360850,12270218,24892558,26594646,19454332,37082578,21664239,30389627,33072916,27705794,23474215,22210453,24934545,23087405,11703363,21870057,29101064,25334067,21392983,35343920,8995530,26321387,24115473,32902017,31708013,24650217,31593305,8678897,23295467,9589557,30537545,12015155,31917967,21084703,27672039,3651426,21338573,7897874,24217116,25709637,24600406,17603751,8180121,32679655,32689497,23094918,34338991,3595867,26238339,21544329,35766614,31328813,27769055,32850381,26133770,34422647,35965075,32400204,30233662,36864841,2983728,29374759,34206371,19308266,23213549,26793309,31272909,23450267,6548378,25148392,34769295,21160030,26038696,26991835,33126474,15225778,35935021,12423648,1658420,32707946,19492419,22084796,20347977,27642554,9774633,29767113,23879537,36979850,35445563,11253922,30972274,23962296,7852330,28978056,20016282,29421501,2081973,16886273,541752,6293494,17604335,34091204,35934270,7313497,24860512,21153145,36338779,24213465,10433176,3777429,7159440,22404326,28491323,36229827,12787802,22219556,34109109,22399586,22312092,36963728,24380919,29652161,10936526,27379369,31667254,30395369[uid]

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Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells.

Munetsuna E, Kawanami R, Nishikawa M, Ikeda S, Nakabayashi S, Yasuda K, Ohta M, Kamakura M, Ikushiro S, Sakaki T. Munetsuna E, et al. Mol Cell Endocrinol. 2014 Feb 15;382(2):960-70. doi: 10.1016/j.mce.2013.11.014. Epub 2013 Nov 27. Mol Cell Endocrinol. 2014. PMID: 24291609

Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse.

Masuda S, Byford V, Arabian A, Sakai Y, Demay MB, St-Arnaud R, Jones G. Masuda S, et al. Endocrinology. 2005 Feb;146(2):825-34. doi: 10.1210/en.2004-1116. Epub 2004 Oct 21. Endocrinology. 2005. PMID: 15498883

Mechanism of the anti-proliferative action of 25-hydroxy-19-nor-vitamin D(3) in human prostate cells.

Munetsuna E, Nakabayashi S, Kawanami R, Yasuda K, Ohta M, Arai MA, Kittaka A, Chen TC, Kamakura M, Ikushiro S, Sakaki T. Munetsuna E, et al. J Mol Endocrinol. 2011 Aug 31;47(2):209-18. doi: 10.1530/JME-11-0008. Print 2011 Oct. J Mol Endocrinol. 2011. PMID: 21693624

Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

Chow EC, Quach HP, Vieth R, Pang KS. Chow EC, et al. Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E977-89. doi: 10.1152/ajpendo.00489.2012. Epub 2013 Mar 12. Am J Physiol Endocrinol Metab. 2013. PMID: 23482451 Free article.

25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells.

Lou YR, Laaksi I, Syvälä H, Bläuer M, Tammela TL, Ylikomi T, Tuohimaa P. Lou YR, et al. FASEB J. 2004 Feb;18(2):332-4. doi: 10.1096/fj.03-0140fje. Epub 2003 Dec 4. FASEB J. 2004. PMID: 14657005

The in vitro evaluation of 25-hydroxyvitamin D3 and 19-nor-1alpha,25-dihydroxyvitamin D2 as therapeutic agents for prostate cancer.

Chen TC, Schwartz GG, Burnstein KL, Lokeshwar BL, Holick MF. Chen TC, et al. Clin Cancer Res. 2000 Mar;6(3):901-8. Clin Cancer Res. 2000. PMID: 10741714

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS. Rhieu SY, et al. J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789. J Cell Biochem. 2014. PMID: 24535953

Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3).

Bareis P, Kállay E, Bischof MG, Bises G, Hofer H, Pötzi C, Manhardt T, Bland R, Cross HS. Bareis P, et al. Exp Cell Res. 2002 Jun 10;276(2):320-7. doi: 10.1006/excr.2002.5528. Exp Cell Res. 2002. PMID: 12027461

25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.

Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P. Lou YR, et al. J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):162-70. doi: 10.1016/j.jsbmb.2009.11.011. Epub 2009 Nov 26. J Steroid Biochem Mol Biol. 2010. PMID: 19944755

Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1.

Urushino N, Nakabayashi S, Arai MA, Kittaka A, Chen TC, Yamamoto K, Hayashi K, Kato S, Ohta M, Kamakura M, Ikushiro S, Sakaki T. Urushino N, et al. Drug Metab Dispos. 2007 Sep;35(9):1482-8. doi: 10.1124/dmd.107.015602. Epub 2007 Jun 6. Drug Metab Dispos. 2007. PMID: 17553915

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