Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 137


Endoproteolytic processing of the mammalian prion glycoprotein family.

Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D.

FEBS J. 2014 Feb;281(3):862-76. doi: 10.1111/febs.12654. Epub 2013 Dec 23.


The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.

Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D.

EMBO J. 2007 Sep 5;26(17):4038-50. Epub 2007 Aug 16.


PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.

Haigh CL, Lewis VA, Vella LJ, Masters CL, Hill AF, Lawson VA, Collins SJ.

Cell Res. 2009 Sep;19(9):1062-78. doi: 10.1038/cr.2009.86. Epub 2009 Jul 14.


PrP N-terminal domain triggers PrP(Sc)-like aggregation of Dpl.

Erlich P, Cesbron JY, Lemaire-Vieille C, Curt A, Andrieu JP, Schoehn G, Jamin M, Gagnon J.

Biochem Biophys Res Commun. 2008 Jan 18;365(3):478-83. Epub 2007 Nov 13.


Expression of the Prion Protein Family Member Shadoo Causes Drug Hypersensitivity That Is Diminished by the Coexpression of the Wild Type Prion Protein.

Nyeste A, Bencsura P, Vida I, Hegyi Z, Homolya L, Fodor E, Welker E.

J Biol Chem. 2016 Feb 26;291(9):4473-86. doi: 10.1074/jbc.M115.679035. Epub 2015 Dec 31.


Wild-type Shadoo proteins convert to amyloid-like forms under native conditions.

Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D.

J Neurochem. 2010 Apr;113(1):92-104. doi: 10.1111/j.1471-4159.2010.06575.x. Epub 2010 Jan 8.


Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.

Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D.

EMBO Mol Med. 2015 Feb 6;7(3):339-56. doi: 10.15252/emmm.201404588.


Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Lewis V, Johanssen VA, Crouch PJ, Klug GM, Hooper NM, Collins SJ.

Cell Mol Life Sci. 2016 Feb;73(3):667-83. doi: 10.1007/s00018-015-2022-z. Epub 2015 Aug 23.


A new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein.

McDonald AJ, Dibble JP, Evans EG, Millhauser GL.

J Biol Chem. 2014 Jan 10;289(2):803-13. doi: 10.1074/jbc.M113.502351. Epub 2013 Nov 18.


Protease-resistant prions selectively decrease Shadoo protein.

Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB.

PLoS Pathog. 2011 Nov;7(11):e1002382. doi: 10.1371/journal.ppat.1002382. Epub 2011 Nov 17.


Prion and doppel proteins bind to granule cells of the cerebellum.

Legname G, Nelken P, Guan Z, Kanyo ZF, DeArmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16285-90. Epub 2002 Nov 21.


Tissue- and cell type-specific modification of prion protein (PrP)-like protein Doppel, which affects PrP endoproteolysis.

Sakudo A, Onodera T.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):523-7. doi: 10.1016/j.bbrc.2010.12.016. Epub 2010 Dec 7.


Conserved stress-protective activity between prion protein and Shadoo.

Sakthivelu V, Seidel RP, Winklhofer KF, Tatzelt J.

J Biol Chem. 2011 Mar 18;286(11):8901-8. doi: 10.1074/jbc.M110.185470. Epub 2011 Jan 21.


Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation.

Westaway D, Genovesi S, Daude N, Brown R, Lau A, Lee I, Mays CE, Coomaraswamy J, Canine B, Pitstick R, Herbst A, Yang J, Ko KW, Schmitt-Ulms G, Dearmond SJ, McKenzie D, Hood L, Carlson GA.

PLoS Pathog. 2011 Nov;7(11):e1002391. doi: 10.1371/journal.ppat.1002391. Epub 2011 Nov 17.


Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation.

Yadavalli R, Guttmann RP, Seward T, Centers AP, Williamson RA, Telling GC.

J Biol Chem. 2004 May 21;279(21):21948-56. Epub 2004 Mar 16.


Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations.

Oliveira-Martins JB, Yusa S, Calella AM, Bridel C, Baumann F, Dametto P, Aguzzi A.

PLoS One. 2010 Feb 8;5(2):e9107. doi: 10.1371/journal.pone.0009107.


Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection.

Lewis V, Hill AF, Haigh CL, Klug GM, Masters CL, Lawson VA, Collins SJ.

J Neuropathol Exp Neurol. 2009 Oct;68(10):1125-35. doi: 10.1097/NEN.0b013e3181b96981.


Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.

Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, Westaway D.

J Biol Chem. 2004 Dec 31;279(53):55443-54. Epub 2004 Sep 29.


PrP(C) homodimerization stimulates the production of PrPC cleaved fragments PrPN1 and PrPC1.

Béland M, Motard J, Barbarin A, Roucou X.

J Neurosci. 2012 Sep 19;32(38):13255-63.


Human Doppel and prion protein share common membrane microdomains and internalization pathways.

Massimino ML, Ballarin C, Bertoli A, Casonato S, Genovesi S, Negro A, Sorgato MC.

Int J Biochem Cell Biol. 2004 Oct;36(10):2016-31.

Items per page

Supplemental Content

Write to the Help Desk