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Items: 1 to 20 of 133

1.

Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks.

Rieswijk L, Lizarraga D, Brauers KJ, Kleinjans JC, van Delft JH.

Mutagenesis. 2014 Jan;29(1):17-26. doi: 10.1093/mutage/get055. Epub 2013 Nov 26.

2.

A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response.

Kruse JJ, Svensson JP, Huigsloot M, Giphart-Gassler M, Schoonen WG, Polman JE, Jean Horbach G, van de Water B, Vrieling H.

Mutat Res. 2007 Apr 1;617(1-2):58-70. Epub 2007 Feb 2.

PMID:
17327130
3.

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.

Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Chesne C, van Delft J, Kleinjans J, Castell J, Bjorquist P, Herwig R, Rogiers V.

Carcinogenesis. 2013 Jun;34(6):1393-402. doi: 10.1093/carcin/bgt054. Epub 2013 Feb 7.

4.

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes.

Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, van Delft JH.

Toxicol In Vitro. 2013 Oct;27(7):2031-40. doi: 10.1016/j.tiv.2013.07.010. Epub 2013 Jul 31.

PMID:
23911569
5.

Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.

van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M.

Arch Toxicol. 2013 Mar;87(3):505-15. doi: 10.1007/s00204-012-0949-5. Epub 2012 Oct 2.

PMID:
23052197
6.

Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets.

van Delft JH, Mathijs K, Staal YC, van Herwijnen MH, Brauers KJ, Boorsma A, Kleinjans JC.

Toxicol Sci. 2010 Oct;117(2):381-92. doi: 10.1093/toxsci/kfq214. Epub 2010 Jul 12.

7.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.

Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC.

Mutagenesis. 2015 Nov;30(6):771-84. doi: 10.1093/mutage/gev036. Epub 2015 May 14.

PMID:
25976910
8.

Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells.

von Stechow L, Ruiz-Aracama A, van de Water B, Peijnenburg A, Danen E, Lommen A.

PLoS One. 2013 Oct 16;8(10):e76476. doi: 10.1371/journal.pone.0076476. eCollection 2013.

9.

Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds.

Vaquero J, Briz O, Herraez E, Muntané J, Marin JJ.

Biochim Biophys Acta. 2013 Oct;1833(10):2212-9. doi: 10.1016/j.bbamcr.2013.05.006. Epub 2013 May 13.

10.

Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells.

Gao X, Sprando RL, Yourick JJ.

Toxicol Appl Pharmacol. 2015 Aug 15;287(1):43-51. doi: 10.1016/j.taap.2015.05.009. Epub 2015 May 23.

PMID:
26006729
11.

Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells.

Burczynski ME, McMillian M, Ciervo J, Li L, Parker JB, Dunn RT 2nd, Hicken S, Farr S, Johnson MD.

Toxicol Sci. 2000 Dec;58(2):399-415.

12.

Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival.

Berger E, Vega N, Vidal H, Geloën A.

Biotechnol J. 2012 Nov;7(11):1395-404. doi: 10.1002/biot.201200188. Epub 2012 Oct 2.

PMID:
22930530
13.

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells.

Pines A, Kelstrup CD, Vrouwe MG, Puigvert JC, Typas D, Misovic B, de Groot A, von Stechow L, van de Water B, Danen EH, Vrieling H, Mullenders LH, Olsen JV.

Mol Cell Biol. 2011 Dec;31(24):4964-77. doi: 10.1128/MCB.05258-11. Epub 2011 Oct 17.

14.

DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines.

Delmastro DA, Li J, Vaisman A, Solle M, Chaney SG.

Cancer Chemother Pharmacol. 1997;39(3):245-53.

PMID:
8996528
15.

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25. Erratum in: J Hepatol. 2016 Feb;64(2):525-6.

16.

RNA-Seq provides new insights in the transcriptome responses induced by the carcinogen benzo[a]pyrene.

van Delft J, Gaj S, Lienhard M, Albrecht MW, Kirpiy A, Brauers K, Claessen S, Lizarraga D, Lehrach H, Herwig R, Kleinjans J.

Toxicol Sci. 2012 Dec;130(2):427-39. doi: 10.1093/toxsci/kfs250. Epub 2012 Aug 13.

17.

The use of genomics technology to investigate gene expression changes in cultured human liver cells.

Harries HM, Fletcher ST, Duggan CM, Baker VA.

Toxicol In Vitro. 2001 Aug-Oct;15(4-5):399-405.

PMID:
11566570
18.

VCC-1 over-expression inhibits cisplatin-induced apoptosis in HepG2 cells.

Zhou Z, Lu X, Zhu P, Zhu W, Mu X, Qu R, Li M.

Biochem Biophys Res Commun. 2012 Apr 6;420(2):336-42. doi: 10.1016/j.bbrc.2012.02.160. Epub 2012 Mar 7.

PMID:
22425983
19.

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH.

Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27.

20.

Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes.

Forgacs AL, Dere E, Angrish MM, Zacharewski TR.

Toxicol Sci. 2013 May;133(1):54-66. doi: 10.1093/toxsci/kft028. Epub 2013 Feb 15.

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