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IL-35: a potential target for the treatment of atherosclerosis.

Huang Y, Lin YZ, Shi Y, Ji QW.

Pharmazie. 2013 Oct;68(10):793-5. Review.


The inhibitory cytokine IL-35 contributes to regulatory T-cell function.

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA.

Nature. 2007 Nov 22;450(7169):566-9.


IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells.

Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, Kempuraj D.

J Biol Regul Homeost Agents. 2010 Apr-Jun;24(2):131-5.


Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells.

Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D.

FASEB J. 2004 Aug;18(11):1318-20. Epub 2004 Jun 4.


Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression.

Zheng XF, Hong YX, Feng GJ, Zhang GF, Rogers H, Lewis MA, Williams DW, Xia ZF, Song B, Wei XQ.

PLoS One. 2013 May 27;8(5):e63967. doi: 10.1371/journal.pone.0063967. Print 2013.


The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.

Hölscher C.

Med Microbiol Immunol. 2004 Feb;193(1):1-17. Epub 2003 Jun 27. Review.


Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.

Devergne O, Birkenbach M, Kieff E.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):12041-6.


IL-12 is required for anti-OX40-mediated CD4 T cell survival.

Ruby CE, Montler R, Zheng R, Shu S, Weinberg AD.

J Immunol. 2008 Feb 15;180(4):2140-8.


A novel p40-independent function of IL-12p35 is required for progression and maintenance of herpes stromal keratitis.

Frank GM, Divito SJ, Maker DM, Xu M, Hendricks RL.

Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3591-8. doi: 10.1167/iovs.09-4368. Epub 2010 Mar 5.


EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation.

Dokmeci E, Xu L, Robinson E, Golubets K, Bottomly K, Herrick CA.

Immunology. 2011 Apr;132(4):559-66. doi: 10.1111/j.1365-2567.2010.03401.x. Epub 2011 Jan 24.


Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.

Dinh TN, Kyaw TS, Kanellakis P, To K, Tipping P, Toh BH, Bobik A, Agrotis A.

Circulation. 2012 Sep 4;126(10):1256-66. doi: 10.1161/CIRCULATIONAHA.112.099044. Epub 2012 Jul 31.


IL-12 contributes to allergen-induced airway inflammation in experimental asthma.

Meyts I, Hellings PW, Hens G, Vanaudenaerde BM, Verbinnen B, Heremans H, Matthys P, Bullens DM, Overbergh L, Mathieu C, De Boeck K, Ceuppens JL.

J Immunol. 2006 Nov 1;177(9):6460-70.


Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t.

Yang J, Yang M, Htut TM, Ouyang X, Hanidu A, Li X, Sellati R, Jiang H, Zhang S, Li H, Zhao J, Ting AT, Mayer L, Unkeless JC, Labadia ME, Hodge M, Li J, Xiong H.

Eur J Immunol. 2008 May;38(5):1204-14. doi: 10.1002/eji.200838145.


Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.

Becher B, Durell BG, Noelle RJ.

J Clin Invest. 2002 Aug;110(4):493-7.


IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available.

Khader SA, Pearl JE, Sakamoto K, Gilmartin L, Bell GK, Jelley-Gibbs DM, Ghilardi N, deSauvage F, Cooper AM.

J Immunol. 2005 Jul 15;175(2):788-95.


Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis.

Zhang GX, Yu S, Gran B, Li J, Siglienti I, Chen X, Calida D, Ventura E, Kamoun M, Rostami A.

J Immunol. 2003 Nov 1;171(9):4485-92.


Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques.

Kempe S, Heinz P, Kokai E, Devergne O, Marx N, Wirth T.

Am J Pathol. 2009 Jul;175(1):440-7. doi: 10.2353/ajpath.2009.080752.

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