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Results: 1 to 20 of 89

1.

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β.

Henderson SJ, Andersson C, Narwal R, Janson J, Goldschmidt TJ, Appelkvist P, Bogstedt A, Steffen AC, Haupts U, Tebbe J, Freskgård PO, Jermutus L, Burrell M, Fowler SB, Webster CI.

Brain. 2014 Feb;137(Pt 2):553-64. doi: 10.1093/brain/awt308. Epub 2013 Nov 20.

PMID:
24259408
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

Walker JR, Pacoma R, Watson J, Ou W, Alves J, Mason DE, Peters EC, Urbina HD, Welzel G, Althage A, Liu B, Tuntland T, Jacobson LH, Harris JL, Schumacher AM.

J Neurosci. 2013 Feb 6;33(6):2457-64. doi: 10.1523/JNEUROSCI.3407-12.2013.

PMID:
23392674
[PubMed - indexed for MEDLINE]
Free Article
3.

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β.

Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H.

J Alzheimers Dis. 2012;28(1):49-69. doi: 10.3233/JAD-2011-110977.

PMID:
21955818
[PubMed - indexed for MEDLINE]
4.

Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.

Am J Pathol. 2007 Jul;171(1):241-51.

PMID:
17591969
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

Mao P, Manczak M, Calkins MJ, Truong Q, Reddy TP, Reddy AP, Shirendeb U, Lo HH, Rabinovitch PS, Reddy PH.

Hum Mol Genet. 2012 Jul 1;21(13):2973-90. doi: 10.1093/hmg/dds128. Epub 2012 Apr 5.

PMID:
22492996
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease.

Choi IS, Lee YJ, Choi DY, Lee YK, Lee YH, Kim KH, Kim YH, Jeon YH, Kim EH, Han SB, Jung JK, Yun YP, Oh KW, Hwang DY, Hong JT.

J Alzheimers Dis. 2011;27(1):127-41. doi: 10.3233/JAD-2011-110545.

PMID:
21799245
[PubMed - indexed for MEDLINE]
8.

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice.

Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E.

BMC Neurosci. 2008 Nov 12;9:109. doi: 10.1186/1471-2202-9-109.

PMID:
19014502
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Circulating neprilysin clears brain amyloid.

Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB.

Mol Cell Neurosci. 2010 Oct;45(2):101-7. doi: 10.1016/j.mcn.2010.05.014. Epub 2010 Jun 15.

PMID:
20558294
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice.

Park MH, Lee JK, Choi S, Ahn J, Jin HK, Park JS, Bae JS.

Brain Res. 2013 Sep 5;1529:113-24. doi: 10.1016/j.brainres.2013.05.045. Epub 2013 Jul 2.

PMID:
23831521
[PubMed - indexed for MEDLINE]
11.

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver.

Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, Khanna P, Jain SC, Thakur SS, Ravindranath V.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3510-5. doi: 10.1073/pnas.1112209109. Epub 2012 Jan 30.

PMID:
22308347
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.

Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T.

Am J Pathol. 2005 May;166(5):1475-85.

PMID:
15855647
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains.

Liu Y, Hua Q, Lei H, Li P.

J Ethnopharmacol. 2011 Sep 2;137(2):1035-46. doi: 10.1016/j.jep.2011.07.031. Epub 2011 Jul 20.

PMID:
21798326
[PubMed - indexed for MEDLINE]
14.

Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease.

El-Amouri SS, Zhu H, Yu J, Marr R, Verma IM, Kindy MS.

Am J Pathol. 2008 May;172(5):1342-54. doi: 10.2353/ajpath.2008.070620. Epub 2008 Apr 10.

PMID:
18403590
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Age-dependent neuroplasticity mechanisms in Alzheimer Tg2576 mice following modulation of brain amyloid-β levels.

Lilja AM, Röjdner J, Mustafiz T, Thomé CM, Storelli E, Gonzalez D, Unger-Lithner C, Greig NH, Nordberg A, Marutle A.

PLoS One. 2013;8(3):e58752. doi: 10.1371/journal.pone.0058752. Epub 2013 Mar 15.

PMID:
23554921
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy.

Barua NU, Miners JS, Bienemann AS, Wyatt MJ, Welser K, Tabor AB, Hailes HC, Love S, Gill SS.

J Alzheimers Dis. 2012;32(1):43-56.

PMID:
22751177
[PubMed - indexed for MEDLINE]
17.

Interactions between amyloid-β and hemoglobin: implications for amyloid plaque formation in Alzheimer's disease.

Chuang JY, Lee CW, Shih YH, Yang T, Yu L, Kuo YM.

PLoS One. 2012;7(3):e33120. doi: 10.1371/journal.pone.0033120. Epub 2012 Mar 6.

PMID:
22412990
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.

Niikura T, Sidahmed E, Hirata-Fukae C, Aisen PS, Matsuoka Y.

PLoS One. 2011 Jan 17;6(1):e16259. doi: 10.1371/journal.pone.0016259.

PMID:
21264226
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E.

J Neurosci. 2003 Mar 15;23(6):1992-6.

PMID:
12657655
[PubMed - indexed for MEDLINE]
Free Article
20.

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

Spencer B, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E.

PLoS One. 2011 Jan 31;6(1):e16575. doi: 10.1371/journal.pone.0016575.

PMID:
21304989
[PubMed - indexed for MEDLINE]
Free PMC Article

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