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Cardiovascular and renal effects of high salt diet in GDNF+/- mice with low nephron number.

Schlote J, Schröder A, Dahlmann A, Karpe B, Cordasic N, Daniel C, Hilgers KF, Titze J, Amann K, Benz K.

Kidney Blood Press Res. 2013;37(4-5):379-91. doi: 10.1159/000355716. Epub 2013 Sep 27.


High-salt diet reveals the hypertensive and renal effects of reduced nephron endowment.

Ruta LA, Dickinson H, Thomas MC, Denton KM, Anderson WP, Kett MM.

Am J Physiol Renal Physiol. 2010 Jun;298(6):F1384-92. doi: 10.1152/ajprenal.00049.2010. Epub 2010 Mar 24.


Early glomerular alterations in genetically determined low nephron number.

Benz K, Campean V, Cordasic N, Karpe B, Neuhuber W, Mall G, Hartner A, Hilgers KF, Amann K.

Am J Physiol Renal Physiol. 2011 Feb;300(2):F521-30. doi: 10.1152/ajprenal.00490.2009. Epub 2010 Oct 13.


Nephron number, renal function, and arterial pressure in aged GDNF heterozygous mice.

Cullen-McEwen LA, Kett MM, Dowling J, Anderson WP, Bertram JF.

Hypertension. 2003 Feb;41(2):335-40.


Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice.

Cullen-McEwen LA, Drago J, Bertram JF.

Kidney Int. 2001 Jul;60(1):31-6.


Glomerular surface area is normalized in mice born with a nephron deficit: no role for AT1 receptors.

Shweta A, Cullen-McEwen LA, Kett MM, Evans RG, Denton KM, Fitzgerald SM, Anderson WP, Bertram JF.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F583-9. doi: 10.1152/ajprenal.90359.2008. Epub 2008 Dec 23.


High nephron endowment protects against salt-induced hypertension.

Walker KA, Cai X, Caruana G, Thomas MC, Bertram JF, Kett MM.

Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F253-8. doi: 10.1152/ajprenal.00028.2012. Epub 2012 May 9.


Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity?

Gurusinghe S, Brown RD, Cai X, Samuel CS, Ricardo SD, Thomas MC, Kett MM.

PLoS One. 2013 Sep 3;8(9):e73095. doi: 10.1371/journal.pone.0073095. eCollection 2013.


Transforming growth factor-beta 1 in hypertensive renal injury in Dahl salt-sensitive rats.

Tamaki K, Okuda S, Nakayama M, Yanagida T, Fujishima M.

J Am Soc Nephrol. 1996 Dec;7(12):2578-89.


Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats.

Wendt N, Schulz A, Siegel AK, Weiss J, Wehland M, Sietmann A, Kossmehl P, Grimm D, Stoll M, Kreutz R.

J Hypertens. 2007 Jan;25(1):95-102. Erratum in: J Hypertens. 2007 Feb;25(2):485.


Both high and low maternal salt intake in pregnancy alter kidney development in the offspring.

Koleganova N, Piecha G, Ritz E, Becker LE, Müller A, Weckbach M, Nyengaard JR, Schirmacher P, Gross-Weissmann ML.

Am J Physiol Renal Physiol. 2011 Aug;301(2):F344-54. doi: 10.1152/ajprenal.00626.2010. Epub 2011 May 18.


Low birth weight in response to salt restriction during pregnancy is not due to alterations in uterine-placental blood flow or the placental and peripheral renin-angiotensin system.

Leandro SM, Furukawa LN, Shimizu MH, Casarini DE, Seguro AC, Patriarca G, Coelho MS, Dolnikoff MS, Heimann JC.

Physiol Behav. 2008 Sep 3;95(1-2):145-51. doi: 10.1016/j.physbeh.2008.05.011. Epub 2008 May 21.


Deletion of cyclooxygenase-2 in the mouse increases arterial blood pressure with no impairment in renal NO production in response to chronic high salt intake.

Stæhr M, Hansen PB, Madsen K, Vanhoutte PM, Nüsing RM, Jensen BL.

Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R899-907. doi: 10.1152/ajpregu.00103.2012. Epub 2013 Mar 27.


Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.

Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1862-71. doi: 10.1152/ajpheart.00513.2011. Epub 2011 Aug 26.


TNF-α type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice.

Singh P, Bahrami L, Castillo A, Majid DS.

Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F991-9. doi: 10.1152/ajprenal.00525.2012. Epub 2013 Feb 6.


Impact of obesity on renal structure and function in the presence and absence of hypertension: evidence from melanocortin-4 receptor-deficient mice.

do Carmo JM, Tallam LS, Roberts JV, Brandon EL, Biglane J, da Silva AA, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R803-12. doi: 10.1152/ajpregu.00187.2009. Epub 2009 Jul 15.


Does a nephron deficit in rats predispose to salt-sensitive hypertension?

Zimanyi MA, Bertram JF, Black MJ.

Kidney Blood Press Res. 2004;27(4):239-47. Epub 2004 Jul 20.


Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.

Luther JM, Luo P, Wang Z, Cohen SE, Kim HS, Fogo AB, Brown NJ.

Kidney Int. 2012 Sep;82(6):643-51. doi: 10.1038/ki.2012.170. Epub 2012 May 23.


Combined prenatal and postnatal protein restriction influences adult kidney structure, function, and arterial pressure.

Hoppe CC, Evans RG, Moritz KM, Cullen-McEwen LA, Fitzgerald SM, Dowling J, Bertram JF.

Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R462-9. Epub 2006 Sep 14.

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