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Results: 1 to 20 of 96

1.

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion.

Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin V, Sun J, Druck T, Zhang J, Huebner K.

PLoS One. 2013 Nov 14;8(11):e80730. doi: 10.1371/journal.pone.0080730. eCollection 2013.

PMID:
24244712
[PubMed - in process]
Free PMC Article
2.

Initiation of genome instability and preneoplastic processes through loss of Fhit expression.

Saldivar JC, Miuma S, Bene J, Hosseini SA, Shibata H, Sun J, Wheeler LJ, Mathews CK, Huebner K.

PLoS Genet. 2012;8(11):e1003077. doi: 10.1371/journal.pgen.1003077. Epub 2012 Nov 29.

PMID:
23209436
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The role of deletions at the FRA3B/FHIT locus in carcinogenesis.

Huebner K, Druck T, Siprashvili Z, Croce CM, Kovatich A, McCue PA.

Recent Results Cancer Res. 1998;154:200-15.

PMID:
10027001
[PubMed - indexed for MEDLINE]
4.

The FHIT gene product: tumor suppressor and genome "caretaker".

Waters CE, Saldivar JC, Hosseini SA, Huebner K.

Cell Mol Life Sci. 2014 Dec;71(23):4577-87. doi: 10.1007/s00018-014-1722-0. Epub 2014 Oct 5.

PMID:
25283145
[PubMed - in process]
5.

A Fhit-ing role in the DNA damage checkpoint response.

Ishii H, Wang Y, Huebner K.

Cell Cycle. 2007 May 2;6(9):1044-8. Epub 2007 May 29. Review.

PMID:
17457056
[PubMed - indexed for MEDLINE]
Free Article
6.

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.

Fong KM, Biesterveld EJ, Virmani A, Wistuba I, Sekido Y, Bader SA, Ahmadian M, Ong ST, Rassool FV, Zimmerman PV, Giaccone G, Gazdar AF, Minna JD.

Cancer Res. 1997 Jun 1;57(11):2256-67.

PMID:
9187130
[PubMed - indexed for MEDLINE]
Free Article
7.

Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.

Karras JR, Paisie CA, Huebner K.

Cancers (Basel). 2014 Jun 4;6(2):1208-19. doi: 10.3390/cancers6021208.

PMID:
24901304
[PubMed]
Free PMC Article
8.

Replication stress induces tumor-like microdeletions in FHIT/FRA3B.

Durkin SG, Ragland RL, Arlt MF, Mulle JG, Warren ST, Glover TW.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):246-51. Epub 2007 Dec 27.

PMID:
18162546
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.

Ong ST, Fong KM, Bader SA, Minna JD, Le Beau MM, McKeithan TW, Rassool FV.

Genes Chromosomes Cancer. 1997 Sep;20(1):16-23.

PMID:
9290949
[PubMed - indexed for MEDLINE]
10.

Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.

Ahmadian M, Wistuba II, Fong KM, Behrens C, Kodagoda DR, Saboorian MH, Shay J, Tomlinson GE, Blum J, Minna JD, Gazdar AF.

Cancer Res. 1997 Sep 1;57(17):3664-8.

PMID:
9288768
[PubMed - indexed for MEDLINE]
Free Article
11.

Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.

Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M, Huebner K.

Cancer Res. 2008 May 15;68(10):3662-70. doi: 10.1158/0008-5472.CAN-07-5687.

PMID:
18483248
[PubMed - indexed for MEDLINE]
Free Article
12.

Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas.

Hilgers W, Groot Koerkamp B, Geradts J, Tang DJ, Yeo CJ, Hruban RH, Kern SE.

Genes Chromosomes Cancer. 2000 Mar;27(3):239-43.

PMID:
10679912
[PubMed - indexed for MEDLINE]
13.

Genetic instability of the tumor suppressor gene FHIT in normal human cells.

Palumbo E, Tosoni E, Matricardi L, Russo A.

Genes Chromosomes Cancer. 2013 Sep;52(9):832-44. doi: 10.1002/gcc.22079. Epub 2013 Jun 18.

PMID:
23780737
[PubMed - indexed for MEDLINE]
14.

Fragile gene product, Fhit, in oxidative and replicative stress responses.

Okumura H, Ishii H, Pichiorri F, Croce CM, Mori M, Huebner K.

Cancer Sci. 2009 Jul;100(7):1145-50. doi: 10.1111/j.1349-7006.2009.01168.x. Epub 2009 Mar 23. Review.

PMID:
19486340
[PubMed - indexed for MEDLINE]
15.

Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.

Muller CY, O'Boyle JD, Fong KM, Wistuba II, Biesterveld E, Ahmadian M, Miller DS, Gazdar AF, Minna JD.

J Natl Cancer Inst. 1998 Mar 18;90(6):433-9.

PMID:
9521167
[PubMed - indexed for MEDLINE]
Free Article
16.

Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites.

Ishii H, Mimori K, Inageta T, Murakumo Y, Vecchione A, Mori M, Furukawa Y.

Mol Cancer Res. 2005 Mar;3(3):130-8.

PMID:
15798093
[PubMed - indexed for MEDLINE]
Free Article
17.

Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas.

Michael D, Beer DG, Wilke CW, Miller DE, Glover TW.

Oncogene. 1997 Oct 2;15(14):1653-9.

PMID:
9349498
[PubMed - indexed for MEDLINE]
Free Article
18.

Induction of the common fragile site FRA3B does not affect FHIT expression.

Michael D, Rajewsky MF.

Oncogene. 2001 Mar 29;20(14):1798-801.

PMID:
11313927
[PubMed - indexed for MEDLINE]
Free Article
19.

Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).

Garinis GA, Gorgoulis VG, Mariatos G, Zacharatos P, Kotsinas A, Liloglou T, Foukas P, Kanavaros P, Kastrinakis NG, Vassilakopoulos T, Vogiatzi T, Field JK, Kittas C.

J Pathol. 2001 Jan;193(1):55-65.

PMID:
11169516
[PubMed - indexed for MEDLINE]
20.

Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells.

Ji WD, Chen JK, Lu JC, Wu ZL, Yi F, Feng SM.

Biomed Environ Sci. 2006 Aug;19(4):277-84.

PMID:
17044645
[PubMed - indexed for MEDLINE]

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