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Items: 1 to 20 of 121

1.

Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats.

Kuroda K, Hibi D, Ishii Y, Takasu S, Kijima A, Matsushita K, Masumura K, Watanabe M, Sugita-Konishi Y, Sakai H, Yanai T, Nohmi T, Ogawa K, Umemura T.

Mutagenesis. 2014 Jan;29(1):27-36. doi: 10.1093/mutage/get054. Epub 2013 Nov 16.

2.

Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.

Hibi D, Kijima A, Suzuki Y, Ishii Y, Jin M, Sugita-Konishi Y, Yanai T, Nishikawa A, Umemura T.

Toxicology. 2013 Feb 8;304:92-9. doi: 10.1016/j.tox.2012.12.005. Epub 2012 Dec 20.

PMID:
23261758
3.

Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression.

Hibi D, Kijima A, Kuroda K, Suzuki Y, Ishii Y, Jin M, Nakajima M, Sugita-Konishi Y, Yanai T, Nohmi T, Nishikawa A, Umemura T.

J Toxicol Sci. 2013 Feb;38(1):57-69.

4.

Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.

Kuroda K, Hibi D, Ishii Y, Yokoo Y, Takasu S, Kijima A, Matsushita K, Masumura K, Kodama Y, Yanai T, Sakai H, Nohmi T, Ogawa K, Umemura T.

Toxicol Sci. 2015 Mar;144(1):65-76. doi: 10.1093/toxsci/kfu267. Epub 2015 Jan 29.

5.

Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A.

Hibi D, Suzuki Y, Ishii Y, Jin M, Watanabe M, Sugita-Konishi Y, Yanai T, Nohmi T, Nishikawa A, Umemura T.

Toxicol Sci. 2011 Aug;122(2):406-14. doi: 10.1093/toxsci/kfr139. Epub 2011 May 27.

6.

Downregulation of Rad51 participates in OTA-induced DNA double-strand breaks in GES-1 cells in vitro.

Lian H, Cui J, Wang Y, Liu J, Wang J, Shen H, Xing L, Wang J, Yan X, Zhang X.

Toxicol Lett. 2014 Apr 21;226(2):214-21. doi: 10.1016/j.toxlet.2014.02.002. Epub 2014 Feb 10.

PMID:
24525463
7.
8.

Ochratoxin a causes DNA damage and cytogenetic effects but no DNA adducts in rats.

Mally A, Pepe G, Ravoori S, Fiore M, Gupta RC, Dekant W, Mosesso P.

Chem Res Toxicol. 2005 Aug;18(8):1253-61.

PMID:
16097798
9.

A newly established GDL1 cell line from gpt delta mice well reflects the in vivo mutation spectra induced by mitomycin C.

Takeiri A, Mishima M, Tanaka K, Shioda A, Harada A, Watanabe K, Masumura K, Nohmi T.

Mutat Res. 2006 Oct 10;609(1):102-15. Epub 2006 Aug 17.

PMID:
16916616
10.

Evaluation of the genotoxicity of tamoxifen in the liver and kidney of F344 gpt delta transgenic rat in 3-week and 13-week repeated dose studies.

Kawamura Y, Hayashi H, Kurata Y, Hiratsuka K, Masumura K, Nohmi T.

Toxicology. 2013 Oct 4;312:56-62. doi: 10.1016/j.tox.2013.07.014. Epub 2013 Jul 30.

PMID:
23907062
11.

Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro.

Cui J, Liu J, Wu S, Wang Y, Shen H, Xing L, Wang J, Yan X, Zhang X.

Arch Toxicol. 2013 Oct;87(10):1829-40. doi: 10.1007/s00204-013-1043-3. Epub 2013 Mar 21.

PMID:
23515941
12.

Ochratoxin A induces karyomegaly and cell cycle aberrations in renal tubular cells without relation to induction of oxidative stress responses in rats.

Taniai E, Yafune A, Nakajima M, Hayashi SM, Nakane F, Itahashi M, Shibutani M.

Toxicol Lett. 2014 Jan 3;224(1):64-72. doi: 10.1016/j.toxlet.2013.10.001. Epub 2013 Oct 11.

PMID:
24120684
13.

Age-related differences in the toxicity of ochratoxin A in female rats.

Dortant PM, Peters-Volleberg GW, Van Loveren H, Marquardt RR, Speijers GJ.

Food Chem Toxicol. 2001 Jan;39(1):55-65.

PMID:
11259851
14.

Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment.

Jiang L, Zhong Y, Akatsuka S, Liu YT, Dutta KK, Lee WH, Onuki J, Masumura K, Nohmi T, Toyokuni S.

Cancer Sci. 2006 Nov;97(11):1159-67. Epub 2006 Aug 22.

15.

Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats.

Rached E, Hard GC, Blumbach K, Weber K, Draheim R, Lutz WK, Ozden S, Steger U, Dekant W, Mally A.

Toxicol Sci. 2007 Jun;97(2):288-98. Epub 2007 Mar 6.

16.

A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: expression profiling in vivo and in vitro employing cDNA microarrays.

Luhe A, Hildebrand H, Bach U, Dingermann T, Ahr HJ.

Toxicol Sci. 2003 Jun;73(2):315-28. Epub 2003 Apr 15.

17.

A new transgenic mouse mutagenesis test system using Spi- and 6-thioguanine selections.

Nohmi T, Katoh M, Suzuki H, Matsui M, Yamada M, Watanabe M, Suzuki M, Horiya N, Ueda O, Shibuya T, Ikeda H, Sofuni T.

Environ Mol Mutagen. 1996;28(4):465-70.

PMID:
8991079
18.

In vivo cII, gpt, and Spi⁻ gene mutation assays in transgenic mice and rats.

Manjanatha MG, Cao X, Shelton SD, Mittelstaedt RA, Heflich RH.

Methods Mol Biol. 2013;1044:97-119. doi: 10.1007/978-1-62703-529-3_5.

PMID:
23896873
19.

Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats.

Mally A, Völkel W, Amberg A, Kurz M, Wanek P, Eder E, Hard G, Dekant W.

Chem Res Toxicol. 2005 Aug;18(8):1242-52.

PMID:
16097797
20.

Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.

Kijima A, Ishii Y, Takasu S, Matsushita K, Kuroda K, Hibi D, Suzuki Y, Nohmi T, Umemura T.

Toxicology. 2015 May 4;331:125-35. doi: 10.1016/j.tox.2015.03.003. Epub 2015 Mar 12.

PMID:
25772432
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