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Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells.

Bhattacharya S, Ray RM, Johnson LR.

Apoptosis. 2014 Mar;19(3):451-66. doi: 10.1007/s10495-013-0942-3.


Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells.

Bhattacharya S, Ray RM, Johnson LR.

Cell Signal. 2009 Apr;21(4):509-22. doi: 10.1016/j.cellsig.2008.12.003. Epub 2008 Dec 24.


RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity.

Guo H, Ray RM, Johnson LR.

Am J Physiol Gastrointest Liver Physiol. 2003 Oct;285(4):G704-13. Epub 2003 Jun 19.


Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.

Pennati M, Campbell AJ, Curto M, Binda M, Cheng Y, Wang LZ, Curtin N, Golding BT, Griffin RJ, Hardcastle IR, Henderson A, Zaffaroni N, Newell DR.

Mol Cancer Ther. 2005 Sep;4(9):1328-37.


Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.

Ray RM, McCormack SA, Johnson LR.

Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G37-43.


p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion.

Zhang AH, Rao JN, Zou T, Liu L, Marasa BS, Xiao L, Chen J, Turner DJ, Wang JY.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C379-89. Epub 2007 Apr 18.


AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.

Raghavan P, Tumati V, Yu L, Chan N, Tomimatsu N, Burma S, Bristow RG, Saha D.

Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-14. doi: 10.1016/j.ijrobp.2012.05.035. Epub 2012 Jul 12.


In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.

DePinto W, Chu XJ, Yin X, Smith M, Packman K, Goelzer P, Lovey A, Chen Y, Qian H, Hamid R, Xiang Q, Tovar C, Blain R, Nevins T, Higgins B, Luistro L, Kolinsky K, Felix B, Hussain S, Heimbrook D.

Mol Cancer Ther. 2006 Nov;5(11):2644-58.


Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2.

Bhattacharya S, Ray RM, Johnson LR.

Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G479-90. Epub 2003 Oct 16.


AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.

Byth KF, Thomas A, Hughes G, Forder C, McGregor A, Geh C, Oakes S, Green C, Walker M, Newcombe N, Green S, Growcott J, Barker A, Wilkinson RW.

Mol Cancer Ther. 2009 Jul;8(7):1856-66. doi: 10.1158/1535-7163.MCT-08-0836. Epub 2009 Jun 9.


Insulin-like growth factors are more effective than progastrin in reversing proapoptotic effects of curcumin: critical role of p38MAPK.

Singh P, Sarkar S, Umar S, Rengifo-Cam W, Singh AP, Wood TG.

Am J Physiol Gastrointest Liver Physiol. 2010 Apr;298(4):G551-62. doi: 10.1152/ajpgi.00497.2009. Epub 2010 Feb 4.


Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

Reynisdóttir I, Polyak K, Iavarone A, Massagué J.

Genes Dev. 1995 Aug 1;9(15):1831-45.


The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons.

Courtney MJ, Coffey ET.

Eur J Neurosci. 1999 Mar;11(3):1073-84.


Inhibition of polyamine oxidase prevented cyclin-dependent kinase inhibitor-induced apoptosis in HCT 116 colon carcinoma cells.

Gürkan AC, Arisan ED, Obakan P, Palavan-Ünsal N.

Apoptosis. 2013 Dec;18(12):1536-47. doi: 10.1007/s10495-013-0885-8.


CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells.

Arisan ED, Obakan P, Coker-Gurkan A, Calcabrini A, Agostinelli E, Unsal NP.

Curr Pharm Des. 2014;20(2):180-8.

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