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Results: 1 to 20 of 101

1.

Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome.

Parvaiz F, Manzoor S, Iqbal J, McRae S, Javed F, Ahmed QL, Waris G.

Arch Virol. 2014 May;159(5):1017-25. doi: 10.1007/s00705-013-1892-3. Epub 2013 Nov 16.

PMID:
24240483
[PubMed - indexed for MEDLINE]
2.

Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β.

Qadri I, Choudhury M, Rahman SM, Knotts TA, Janssen RC, Schaack J, Iwahashi M, Puljak L, Simon FR, Kilic G, Fitz JG, Friedman JE.

J Biol Chem. 2012 Oct 26;287(44):37340-51. doi: 10.1074/jbc.M112.384743. Epub 2012 Sep 6.

PMID:
22955269
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication.

García-Mediavilla MV, Pisonero-Vaquero S, Lima-Cabello E, Benedicto I, Majano PL, Jorquera F, González-Gallego J, Sánchez-Campos S.

Lab Invest. 2012 Aug;92(8):1191-202. doi: 10.1038/labinvest.2012.88. Epub 2012 May 28.

PMID:
22641099
[PubMed - indexed for MEDLINE]
Free Article
4.

The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance.

Shlomai A, Rechtman MM, Burdelova EO, Zilberberg A, Hoffman S, Solar I, Fishman S, Halpern Z, Sklan EH.

J Hepatol. 2012 Oct;57(4):867-73. doi: 10.1016/j.jhep.2012.06.021. Epub 2012 Jun 23.

PMID:
22732512
[PubMed - indexed for MEDLINE]
5.

Hepatitis C virus infection: molecular pathways to insulin resistance.

Parvaiz F, Manzoor S, Tariq H, Javed F, Fatima K, Qadri I.

Virol J. 2011 Oct 18;8:474. doi: 10.1186/1743-422X-8-474. Review.

PMID:
22008087
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells.

Hou W, Tian Q, Zheng J, Bonkovsky HL.

Gastroenterology. 2010 May;138(5):1909-19. doi: 10.1053/j.gastro.2009.11.001. Epub 2009 Nov 10.

PMID:
19909748
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation.

George A, Panda S, Kudmulwar D, Chhatbar SP, Nayak SC, Krishnan HH.

J Biol Chem. 2012 Feb 10;287(7):5042-58. doi: 10.1074/jbc.M111.308916. Epub 2011 Dec 19.

PMID:
22184107
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.

Polyak SJ, Khabar KS, Paschal DM, Ezelle HJ, Duverlie G, Barber GN, Levy DE, Mukaida N, Gretch DR.

J Virol. 2001 Jul;75(13):6095-106.

PMID:
11390611
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase.

Sarcar B, Ghosh AK, Steele R, Ray R, Ray RB.

Virology. 2004 Apr 25;322(1):51-60.

PMID:
15063116
[PubMed - indexed for MEDLINE]
Free Article
10.

Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis.

Park CY, Choi SH, Kang SM, Kang JI, Ahn BY, Kim H, Jung G, Choi KY, Hwang SB.

J Hepatol. 2009 Nov;51(5):853-64. doi: 10.1016/j.jhep.2009.06.026. Epub 2009 Aug 12.

PMID:
19726098
[PubMed - indexed for MEDLINE]
11.

The oncogenic role of NS5A of hepatitis C virus is mediated by up-regulation of survivin gene expression in the hepatocellular cell through p53 and NF-κB pathways.

Jiang YF, He B, Li NP, Ma J, Gong GZ, Zhang M.

Cell Biol Int. 2011 Dec;35(12):1225-32. doi: 10.1042/CBI20110102.

PMID:
21612579
[PubMed - indexed for MEDLINE]
12.

Modulation of the transforming growth factor-beta signal transduction pathway by hepatitis C virus nonstructural 5A protein.

Choi SH, Hwang SB.

J Biol Chem. 2006 Mar 17;281(11):7468-78. Epub 2006 Jan 6.

PMID:
16407286
[PubMed - indexed for MEDLINE]
Free Article
13.

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1.

Xiang Z, Qiao L, Zhou Y, Babiuk LA, Liu Q.

Biochem Biophys Res Commun. 2010 Nov 19;402(3):549-53. doi: 10.1016/j.bbrc.2010.10.081. Epub 2010 Oct 29.

PMID:
20971080
[PubMed - indexed for MEDLINE]
14.

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.

PMID:
14709551
[PubMed - indexed for MEDLINE]
Free Article
15.

Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein.

Fukuma T, Enomoto N, Marumo F, Sato C.

Hepatology. 1998 Oct;28(4):1147-53.

PMID:
9755255
[PubMed - indexed for MEDLINE]
16.

Hepatitis C virus non-structural 5A abrogates signal transducer and activator of transcription-1 nuclear translocation induced by IFN-alpha through dephosphorylation.

Gong GZ, Cao J, Jiang YF, Zhou Y, Liu B.

World J Gastroenterol. 2007 Aug 14;13(30):4080-4.

PMID:
17696225
[PubMed - indexed for MEDLINE]
Free Article
17.

Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly.

Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R.

PLoS Pathog. 2008 Mar 28;4(3):e1000035. doi: 10.1371/journal.ppat.1000035.

PMID:
18369481
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.

He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG.

J Virol. 2002 Sep;76(18):9207-17.

PMID:
12186904
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4.

Tamura R, Kanda T, Imazeki F, Wu S, Nakamoto S, Tanaka T, Arai M, Fujiwara K, Saito K, Roger T, Wakita T, Shirasawa H, Yokosuka O.

J Infect Dis. 2011 Sep 1;204(5):793-801. doi: 10.1093/infdis/jir381.

PMID:
21844306
[PubMed - indexed for MEDLINE]
Free Article
20.

Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3.

Kawaguchi T, Yoshida T, Harada M, Hisamoto T, Nagao Y, Ide T, Taniguchi E, Kumemura H, Hanada S, Maeyama M, Baba S, Koga H, Kumashiro R, Ueno T, Ogata H, Yoshimura A, Sata M.

Am J Pathol. 2004 Nov;165(5):1499-508.

PMID:
15509521
[PubMed - indexed for MEDLINE]
Free PMC Article

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