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Results: 1 to 20 of 100

1.

Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-α (TNF-α) using AZD9773, an anti-TNF-α immune Fab, in murine CLP sepsis.

Newham P, Ross D, Ceuppens P, Das S, Yates JW, Betts C, Reens J, Randall KJ, Knight R, McKay JS.

Inflamm Res. 2014 Feb;63(2):149-60. doi: 10.1007/s00011-013-0683-3. Epub 2013 Nov 17.

PMID:
24240228
[PubMed - indexed for MEDLINE]
2.

A Phase II study of polyclonal anti-TNF-α (AZD9773) in Japanese patients with severe sepsis and/or septic shock.

Aikawa N, Takahashi T, Fujimi S, Yokoyama T, Yoshihara K, Ikeda T, Sadamitsu D, Momozawa M, Maruyama T.

J Infect Chemother. 2013 Oct;19(5):931-40. doi: 10.1007/s10156-013-0612-y. Epub 2013 May 17.

PMID:
23681364
[PubMed - indexed for MEDLINE]
3.

Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*.

Bernard GR, Francois B, Mira JP, Vincent JL, Dellinger RP, Russell JA, Larosa SP, Laterre PF, Levy MM, Dankner W, Schmitt N, Lindemann J, Wittebole X.

Crit Care Med. 2014 Mar;42(3):504-11. doi: 10.1097/CCM.0000000000000043.

PMID:
24335445
[PubMed - indexed for MEDLINE]
4.

Population pharmacokinetic/pharmacodynamic modelling of the anti-TNF-α polyclonal fragment antibody AZD9773 in patients with severe sepsis.

Yates JW, Das S, Mainwaring G, Kemp J.

J Pharmacokinet Pharmacodyn. 2012 Dec;39(6):591-9. doi: 10.1007/s10928-012-9270-4. Epub 2012 Sep 23.

PMID:
23001587
[PubMed - indexed for MEDLINE]
5.

A placebo-controlled, double-blind, dose-escalation study to assess the safety, tolerability and pharmacokinetics/pharmacodynamics of single and multiple intravenous infusions of AZD9773 in patients with severe sepsis and septic shock.

Morris PE, Zeno B, Bernard AC, Huang X, Das S, Edeki T, Simonson SG, Bernard GR.

Crit Care. 2012 Feb 17;16(1):R31. doi: 10.1186/cc11203.

PMID:
22340283
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin.

Villa P, Sartor G, Angelini M, Sironi M, Conni M, Gnocchi P, Isetta AM, Grau G, Buurman W, van Tits LJ, et al.

Clin Diagn Lab Immunol. 1995 Sep;2(5):549-53.

PMID:
8548533
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

CD16 inhibition increases host survival in a murine model of severe sepsis.

Zhang D, He J, Shen M, Wang R.

J Surg Res. 2014 Apr;187(2):605-9. doi: 10.1016/j.jss.2013.11.004. Epub 2013 Nov 12.

PMID:
24331941
[PubMed - indexed for MEDLINE]
8.

Intrahepatic nuclear factor-kappa B activity and alpha 1-acid glycoprotein transcription do not predict outcome after cecal ligation and puncture in the rat.

Chen J, Raj N, Kim P, Andrejko KM, Deutschman CS.

Crit Care Med. 2001 Mar;29(3):589-96.

PMID:
11373425
[PubMed - indexed for MEDLINE]
9.
10.

Combination immunotherapy with soluble tumor necrosis factor receptors plus interleukin 1 receptor antagonist decreases sepsis mortality.

Remick DG, Call DR, Ebong SJ, Newcomb DE, Nybom P, Nemzek JA, Bolgos GE.

Crit Care Med. 2001 Mar;29(3):473-81.

PMID:
11373406
[PubMed - indexed for MEDLINE]
11.

Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture.

Remick D, Manohar P, Bolgos G, Rodriguez J, Moldawer L, Wollenberg G.

Shock. 1995 Aug;4(2):89-95.

PMID:
7496903
[PubMed - indexed for MEDLINE]
12.

Antibiotic treatment influences outcome in murine sepsis: mediators of increased morbidity.

Newcomb D, Bolgos G, Green L, Remick DG.

Shock. 1998 Aug;10(2):110-7.

PMID:
9721977
[PubMed - indexed for MEDLINE]
13.

Balance of inflammatory cytokines related to severity and mortality of murine sepsis.

Walley KR, Lukacs NW, Standiford TJ, Strieter RM, Kunkel SL.

Infect Immun. 1996 Nov;64(11):4733-8.

PMID:
8890233
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats.

Song XM, Wang YL, Li JG, Wang CY, Zhou Q, Zhang ZZ, Liang H.

Mol Biol Rep. 2009 Nov;36(8):2345-51. doi: 10.1007/s11033-009-9456-z. Epub 2009 Feb 4.

PMID:
19190997
[PubMed - indexed for MEDLINE]
15.

Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release.

Vianna RC, Gomes RN, Bozza FA, Amâncio RT, Bozza PT, David CM, Castro-Faria-Neto HC.

Shock. 2004 Feb;21(2):115-20.

PMID:
14752283
[PubMed - indexed for MEDLINE]
16.
17.

Deficiency of alpha-calcitonin gene-related peptide induces inflammatory responses and lethality in sepsis.

Lee JK, Jung JS, Park SH, Sim YB, Suh HW.

Cytokine. 2013 Nov;64(2):548-54. doi: 10.1016/j.cyto.2013.07.030. Epub 2013 Sep 8.

PMID:
24021706
[PubMed - indexed for MEDLINE]
18.

Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis.

Kaplan JM, Nowell M, Lahni P, O'Connor MP, Hake PW, Zingarelli B.

Obesity (Silver Spring). 2012 Oct;20(10):1995-2002. doi: 10.1038/oby.2012.40. Epub 2012 Feb 15.

PMID:
22334256
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice.

Xu L, Bao H, Si Y, Wang X.

Inflamm Res. 2013 May;62(5):507-14. doi: 10.1007/s00011-013-0604-5. Epub 2013 Mar 5.

PMID:
23463181
[PubMed - indexed for MEDLINE]
20.

Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense.

Chen GH, Reddy RC, Newstead MW, Tateda K, Kyasapura BL, Standiford TJ.

J Immunol. 2000 Dec 1;165(11):6496-503.

PMID:
11086090
[PubMed - indexed for MEDLINE]
Free Article

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