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Items: 1 to 20 of 106

1.

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G.

Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14.

2.

Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket.

Leu JI, Zhang P, Murphy ME, Marmorstein R, George DL.

ACS Chem Biol. 2014 Nov 21;9(11):2508-16. doi: 10.1021/cb500236y. Epub 2014 Aug 28.

3.

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

Massey AJ, Williamson DS, Browne H, Murray JB, Dokurno P, Shaw T, Macias AT, Daniels Z, Geoffroy S, Dopson M, Lavan P, Matassova N, Francis GL, Graham CJ, Parsons R, Wang Y, Padfield A, Comer M, Drysdale MJ, Wood M.

Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. doi: 10.1007/s00280-009-1194-3. Epub 2009 Dec 13.

PMID:
20012863
5.

Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

Donnelly A, Blagg BS.

Curr Med Chem. 2008;15(26):2702-17. Review.

6.

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.

Carrello A, Allan RK, Morgan SL, Owen BA, Mok D, Ward BK, Minchin RF, Toft DO, Ratajczak T.

Cell Stress Chaperones. 2004 Summer;9(2):167-81.

7.

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

Powers MV, Jones K, Barillari C, Westwood I, van Montfort RL, Workman P.

Cell Cycle. 2010 Apr 15;9(8):1542-50. Epub 2010 Apr 15.

PMID:
20372081
8.

Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.

Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G.

J Med Chem. 2014 Feb 27;57(4):1208-24. doi: 10.1021/jm401552y. Epub 2014 Feb 18.

9.

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery.

Pratt WB, Toft DO.

Exp Biol Med (Maywood). 2003 Feb;228(2):111-33. Review.

PMID:
12563018
10.

Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP.

Kundrat L, Regan L.

J Mol Biol. 2010 Jan 22;395(3):587-94. doi: 10.1016/j.jmb.2009.11.017. Epub 2009 Nov 12.

11.

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.

Schmid AB, Lagleder S, Gräwert MA, Röhl A, Hagn F, Wandinger SK, Cox MB, Demmer O, Richter K, Groll M, Kessler H, Buchner J.

EMBO J. 2012 Mar 21;31(6):1506-17. doi: 10.1038/emboj.2011.472. Epub 2012 Jan 6.

12.
13.

Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading.

Li J, Qian X, Hu J, Sha B.

J Biol Chem. 2009 Aug 28;284(35):23852-9. doi: 10.1074/jbc.M109.023986. Epub 2009 Jul 6.

14.

Hsp70 chaperones: cellular functions and molecular mechanism.

Mayer MP, Bukau B.

Cell Mol Life Sci. 2005 Mar;62(6):670-84. Review.

15.

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.

Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G.

J Med Chem. 2014 Feb 27;57(4):1188-207. doi: 10.1021/jm401551n. Epub 2014 Feb 18.

16.
17.

A novel mode of chaperone action: heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex.

Lan C, Lee HC, Tang S, Zhang L.

J Biol Chem. 2004 Jun 25;279(26):27607-12. Epub 2004 Apr 21.

18.

A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.

El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2014 Oct 17;289(42):28987-9000. doi: 10.1074/jbc.M114.595090. Epub 2014 Sep 8.

19.

Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions.

Walerych D, Olszewski MB, Gutkowska M, Helwak A, Zylicz M, Zylicz A.

Oncogene. 2009 Dec 3;28(48):4284-94. doi: 10.1038/onc.2009.281. Epub 2009 Sep 14.

PMID:
19749793
20.

PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

Zhou J, Schmid T, Frank R, Brüne B.

J Biol Chem. 2004 Apr 2;279(14):13506-13. Epub 2004 Jan 15.

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