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Results: 1 to 20 of 103

1.

PGE 2 desensitizes β -agonist effect on human lung fibroblast-mediated collagen gel contraction through upregulating PDE4.

Fang Q, Ma Y, Wang J, Michalski J, Rennard SI, Liu X.

Mediators Inflamm. 2013;2013:145197. doi: 10.1155/2013/145197. Epub 2013 Oct 8.

PMID:
24227907
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.

Michalski J, Kanaji N, Liu X, Nogel S, Wang X, Basma H, Nakanishi M, Sato T, Gunji Y, Fahrid M, Nelson A, Muller KC, Holz O, Magnussen H, Rabe KF, Toews ML, Rennard SI.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):729-37. doi: 10.1165/rcmb.2012-0057OC. Epub 2012 Oct 4.

PMID:
23043089
[PubMed - indexed for MEDLINE]
3.

PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels.

Kohyama T, Liu X, Wen FQ, Zhu YK, Wang H, Kim HJ, Takizawa H, Cieslinski LB, Barnette MS, Rennard SI.

Am J Respir Cell Mol Biol. 2002 Jun;26(6):694-701.

PMID:
12034568
[PubMed - indexed for MEDLINE]
4.

PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts.

Togo S, Liu X, Wang X, Sugiura H, Kamio K, Kawasaki S, Kobayashi T, Ertl RF, Ahn Y, Holz O, Magnussen H, Fredriksson K, Skold CM, Rennard SI.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. doi: 10.1152/ajplung.00508.2007. Epub 2009 Mar 20.

PMID:
19304913
[PubMed - indexed for MEDLINE]
Free Article
5.

Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2.

Ikari J, Michalski JM, Iwasawa S, Gunji Y, Nogel S, Park JH, Nelson AJ, Farid M, Wang X, Schulte N, Basma H, Toews ML, Feghali-Bostwick C, Tenor H, Liu X, Rennard SI.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):571-81. doi: 10.1165/rcmb.2013-0004OC.

PMID:
23656623
[PubMed - indexed for MEDLINE]
6.

Cytokine inhibition of fibroblast-induced gel contraction is mediated by PGE(2) and NO acting through separate parallel pathways.

Zhu YK, Liu XD, Sköld MC, Umino T, Wang H, Romberger DJ, Spurzem JR, Kohyama T, Wen FQ, Rennard SI.

Am J Respir Cell Mol Biol. 2001 Aug;25(2):245-53.

PMID:
11509336
[PubMed - indexed for MEDLINE]
7.

Cytokines modulate cilomilast response in lung fibroblasts.

Kohyama T, Liu X, Wen FQ, Kobayashi T, Fang Q, Abe S, Cieslinski L, Barnette MS, Rennard SI.

Clin Immunol. 2004 Jun;111(3):297-302.

PMID:
15183150
[PubMed - indexed for MEDLINE]
8.

Glucocorticoids augment fibroblast-mediated contraction of collagen gels by inhibition of endogenous PGE production.

Sköld CM, Liu XD, Zhu YK, Umino T, Takigawa K, Ohkuni Y, Ertl RF, Spurzem JR, Romberger DJ, Brattsand R, Rennard SI.

Proc Assoc Am Physicians. 1999 May-Jun;111(3):249-58.

PMID:
10354365
[PubMed - indexed for MEDLINE]
9.

Phosphodiesterase 4 inhibition of beta2-integrin adhesion caused by leukotriene B4 and TNF-alpha in human neutrophils.

Meliton AY, Muñoz NM, Lambertino A, Boetticher E, Learoyd J, Zhu X, Leff AR.

Eur Respir J. 2006 Nov;28(5):920-8. Epub 2006 Jun 28.

PMID:
16807266
[PubMed - indexed for MEDLINE]
Free Article
10.

Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.

Kohyama T, Liu X, Zhu YK, Wen FQ, Wang HJ, Fang Q, Kobayashi T, Rennard SI.

Am J Respir Cell Mol Biol. 2002 Oct;27(4):487-94.

PMID:
12356583
[PubMed - indexed for MEDLINE]
11.

Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists.

Torphy TJ, Zhou HL, Foley JJ, Sarau HM, Manning CD, Barnette MS.

J Biol Chem. 1995 Oct 6;270(40):23598-604.

PMID:
7559525
[PubMed - indexed for MEDLINE]
Free Article
12.

Human bronchial epithelial cells modulate collagen gel contraction by fibroblasts.

Mio T, Liu XD, Adachi Y, Striz I, Sköld CM, Romberger DJ, Spurzem JR, Illig MG, Ertl R, Rennard SI.

Am J Physiol. 1998 Jan;274(1 Pt 1):L119-26.

PMID:
9458809
[PubMed - indexed for MEDLINE]
Free Article
13.

Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.

Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI.

Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1049-56.

PMID:
11943670
[PubMed - indexed for MEDLINE]
Free Article
14.

Glucocorticoids and TGF-beta1 synergize in augmenting fibroblast mediated contraction of collagen gels.

Wen FQ, Sköld CM, Liu XD, Ertl RF, Zhu YK, Kohyama T, Wang H, Rennard SI.

Inflammation. 2001 Apr;25(2):109-17.

PMID:
11321357
[PubMed - indexed for MEDLINE]
15.

Sodium nitroprusside augments human lung fibroblast collagen gel contraction independently of NO-cGMP pathway.

Liu XD, Skold CM, Umino T, Spurzem JR, Romberger DJ, Rennard SI.

Am J Physiol Lung Cell Mol Physiol. 2000 May;278(5):L1032-8.

PMID:
10781435
[PubMed - indexed for MEDLINE]
Free Article
16.

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice.

Udalov S, Dumitrascu R, Pullamsetti SS, Al-tamari HM, Weissmann N, Ghofrani HA, Guenther A, Voswinckel R, Seeger W, Grimminger F, Schermuly RT.

BMC Pulm Med. 2010 May 5;10:26. doi: 10.1186/1471-2466-10-26.

PMID:
20444277
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2.

Munisso MC, Kang JH, Tsurufuji M, Yamaoka T.

Biochimie. 2012 Nov;94(11):2360-5. doi: 10.1016/j.biochi.2012.05.031. Epub 2012 Jun 15.

PMID:
22706281
[PubMed - indexed for MEDLINE]
18.

Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dual β₂-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD.

Liu A, Huang L, Wang Z, Luo Z, Mao F, Shan W, Xie J, Lai K, Li X.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1548-52. doi: 10.1016/j.bmcl.2012.11.058. Epub 2012 Nov 29.

PMID:
23375225
[PubMed - indexed for MEDLINE]
19.

Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction.

Carnevali S, Nakamura Y, Mio T, Liu X, Takigawa K, Romberger DJ, Spurzem JR, Rennard SI.

Am J Physiol. 1998 Apr;274(4 Pt 1):L591-8.

PMID:
9575878
[PubMed - indexed for MEDLINE]
Free Article
20.

Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition.

Selige J, Tenor H, Hatzelmann A, Dunkern T.

J Cell Physiol. 2010 May;223(2):317-26. doi: 10.1002/jcp.22037.

PMID:
20082309
[PubMed - indexed for MEDLINE]

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