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Results: 1 to 20 of 112

Similar articles for PubMed (Select 24224048)

1.

Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension.

Frump AL, Lowery JW, Hamid R, Austin ED, de Caestecker M.

PLoS One. 2013 Nov 5;8(11):e80319. doi: 10.1371/journal.pone.0080319. eCollection 2013.

2.

Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertension.

Prewitt AR, Ghose S, Frump AL, Datta A, Austin ED, Kenworthy AK, de Caestecker MP.

J Biol Chem. 2015 Jan 9;290(2):960-71. doi: 10.1074/jbc.M114.591057. Epub 2014 Nov 19.

PMID:
25411245
3.

Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension.

Drake KM, Dunmore BJ, McNelly LN, Morrell NW, Aldred MA.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):403-9. doi: 10.1165/rcmb.2013-0100OC.

4.

Defective cellular trafficking of the bone morphogenetic protein receptor type II by mutations underlying familial pulmonary arterial hypertension.

John A, Kizhakkedath P, Al-Gazali L, Ali BR.

Gene. 2015 Apr 25;561(1):148-56. doi: 10.1016/j.gene.2015.02.038. Epub 2015 Feb 14.

PMID:
25688877
5.

Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance.

Flynn C, Zheng S, Yan L, Hedges L, Womack B, Fessel J, Cogan J, Austin E, Loyd J, West J, Zhao Z, Hamid R.

Am J Respir Cell Mol Biol. 2012 Jul;47(1):20-7. doi: 10.1165/rcmb.2011-0251OC. Epub 2012 Feb 3.

6.

Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.

Leyton PA, Beppu H, Pappas A, Martyn TM, Derwall M, Baron DM, Galdos R, Bloch DB, Bloch KD.

PLoS One. 2013 Oct 8;8(10):e76947. doi: 10.1371/journal.pone.0076947. eCollection 2013.

7.

Bone morphogenetic protein type II receptor mutations causing protein misfolding in heritable pulmonary arterial hypertension.

Li W, Dunmore BJ, Morrell NW.

Proc Am Thorac Soc. 2010 Nov;7(6):395-8. doi: 10.1513/pats.201002-024AW. Review.

PMID:
21030519
8.

BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension.

Talati M, West J, Blackwell TR, Loyd JE, Meyrick B.

Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L363-73. doi: 10.1152/ajplung.00295.2009. Epub 2010 Jun 18.

9.

Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.

Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J.

Am J Respir Crit Care Med. 2014 Feb 1;189(3):325-34. doi: 10.1164/rccm.201306-1086OC.

10.

Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension.

Hamid R, Hedges LK, Austin E, Phillips JA 3rd, Loyd JE, Cogan JD.

Clin Genet. 2010 Mar;77(3):280-6. doi: 10.1111/j.1399-0004.2009.01311.x. Epub 2010 Jan 20.

11.

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue.

Sobolewski A, Rudarakanchana N, Upton PD, Yang J, Crilley TK, Trembath RC, Morrell NW.

Hum Mol Genet. 2008 Oct 15;17(20):3180-90. doi: 10.1093/hmg/ddn214. Epub 2008 Jul 21.

12.

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.

Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L98-109. Epub 2007 Nov 16.

13.

Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension.

Yang J, Davies RJ, Southwood M, Long L, Yang X, Sobolewski A, Upton PD, Trembath RC, Morrell NW.

Circ Res. 2008 May 23;102(10):1212-21. doi: 10.1161/CIRCRESAHA.108.173567. Epub 2008 Apr 24.

14.

Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8.

Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, Erzurum SC, Aldred MA.

Am J Respir Crit Care Med. 2011 Dec 15;184(12):1400-8. doi: 10.1164/rccm.201106-1130OC. Epub 2011 Sep 15.

15.

Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.

Song Y, Coleman L, Shi J, Beppu H, Sato K, Walsh K, Loscalzo J, Zhang YY.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H677-90. doi: 10.1152/ajpheart.91519.2007. Epub 2008 Jun 13. Erratum in: Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1544.

16.

Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele.

Hamid R, Cogan JD, Hedges LK, Austin E, Phillips JA 3rd, Newman JH, Loyd JE.

Hum Mutat. 2009 Apr;30(4):649-54. doi: 10.1002/humu.20922.

17.

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.

Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 1;302(5):L474-84. doi: 10.1152/ajplung.00202.2011. Epub 2011 Dec 16.

18.

Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension.

Phillips JA 3rd, Poling JS, Phillips CA, Stanton KC, Austin ED, Cogan JD, Wheeler L, Yu C, Newman JH, Dietz HC, Loyd JE.

Genet Med. 2008 May;10(5):359-65. doi: 10.1097/GIM.0b013e318172dcdf.

PMID:
18496036
19.
20.

SMAD1 deficiency in either endothelial or smooth muscle cells can predispose mice to pulmonary hypertension.

Han C, Hong KH, Kim YH, Kim MJ, Song C, Kim MJ, Kim SJ, Raizada MK, Oh SP.

Hypertension. 2013 May;61(5):1044-52. doi: 10.1161/HYPERTENSIONAHA.111.199158. Epub 2013 Mar 11.

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