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Items: 1 to 20 of 100

1.

K-Ras, intestinal homeostasis and colon cancer.

Goel S, Huang J, Klampfer L.

Curr Clin Pharmacol. 2015;10(1):73-81.

PMID:
24219000
2.

ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.

Toulany M, Minjgee M, Saki M, Holler M, Meier F, Eicheler W, Rodemann HP.

Cancer Biol Ther. 2014 Mar 1;15(3):317-28. doi: 10.4161/cbt.27311. Epub 2013 Dec 9.

3.

Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.

Baykara O, Tansarikaya M, Demirkaya A, Kaynak K, Tanju S, Toker A, Buyru N.

Exp Ther Med. 2013 Feb;5(2):495-498. Epub 2012 Nov 23.

4.

Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.

Basu Roy UK, Henkhaus RS, Loupakis F, Cremolini C, Gerner EW, Ignatenko NA.

Int J Cancer. 2013 Jul;133(1):43-57. doi: 10.1002/ijc.28001. Epub 2013 Feb 12. Erratum in: Int J Cancer. 2015 Oct 15;137(8):E18.

5.

Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.

Califano R, Landi L, Cappuzzo F.

Drugs. 2012 Jun 19;72 Suppl 1:28-36. doi: 10.2165/1163012-S0-000000000-00000. Review.

PMID:
22712795
6.

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.

Nat Genet. 2008 May;40(5):600-8. doi: 10.1038/ng.115. Epub 2008 Mar 30.

7.

Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.

Yip-Schneider MT, Lin A, Barnard D, Sweeney CJ, Marshall MS.

Int J Oncol. 1999 Aug;15(2):271-9.

PMID:
10402237
8.

Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.

Padavano J, Henkhaus RS, Chen H, Skovan BA, Cui H, Ignatenko NA.

Cancer Growth Metastasis. 2015 Oct 19;8(Suppl 1):95-113. doi: 10.4137/CGM.S29407. eCollection 2015.

9.

Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer.

Palmirotta R, Savonarola A, Ludovici G, De Marchis ML, Covello R, Ettorre GM, Ialongo C, Guadagni F.

Folia Histochem Cytobiol. 2011;49(4):729-33.

10.

Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.

Naguib A, Wilson CH, Adams DJ, Arends MJ.

J Mol Signal. 2011 Mar 3;6:2. doi: 10.1186/1750-2187-6-2.

11.

Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.

Carón RW, Yacoub A, Mitchell C, Zhu X, Hong Y, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P.

Cell Cycle. 2005 Mar;4(3):456-64. Epub 2005 Mar 28.

PMID:
15655348
12.

Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium.

Keller JW, Franklin JL, Graves-Deal R, Friedman DB, Whitwell CW, Coffey RJ.

J Cell Physiol. 2007 Mar;210(3):740-9.

PMID:
17133351
13.

Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.

Yuen HF, Chan KK, Grills C, Murray JT, Platt-Higgins A, Eldin OS, O'Byrne K, Janne P, Fennell DA, Johnston PG, Rudland PS, El-Tanani M.

Clin Cancer Res. 2012 Jan 15;18(2):380-91. doi: 10.1158/1078-0432.CCR-11-2035. Epub 2011 Nov 16.

14.

K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.

Minjgee M, Toulany M, Kehlbach R, Giehl K, Rodemann HP.

Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1506-14. doi: 10.1016/j.ijrobp.2011.05.057. Epub 2011 Oct 8.

PMID:
21985943
15.

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL.

Nat Struct Mol Biol. 2013 Jan;20(1):46-52. doi: 10.1038/nsmb.2430. Epub 2012 Nov 25.

16.

High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.

Wang JY, Hsieh JS, Chen FM, Yeh CS, Alexandersen K, Huang TJ, Chen Dc, Lin SR.

Int J Cancer. 2003 Nov 10;107(3):387-93.

18.

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.

Calcagno SR, Li S, Colon M, Kreinest PA, Thompson EA, Fields AP, Murray NR.

Int J Cancer. 2008 Jun 1;122(11):2462-70. doi: 10.1002/ijc.23383.

19.

Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.

Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, Sartor CI.

Clin Cancer Res. 2010 Feb 1;16(3):912-23. doi: 10.1158/1078-0432.CCR-09-1324. Epub 2010 Jan 26.

20.

K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.

Samuel MS, Lourenço FC, Olson MF.

PLoS One. 2011 Feb 15;6(2):e17143. doi: 10.1371/journal.pone.0017143.

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