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Items: 1 to 20 of 97

1.

Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists.

Vinader V, Ahmet DS, Ahmed MS, Patterson LH, Afarinkia K.

PLoS One. 2013 Oct 18;8(10):e78744. doi: 10.1371/journal.pone.0078744. eCollection 2013.

2.

Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction.

Ziarek JJ, Liu Y, Smith E, Zhang G, Peterson FC, Chen J, Yu Y, Chen Y, Volkman BF, Li R.

Curr Top Med Chem. 2012;12(24):2727-40.

3.

Anti-HIV small-molecule binding in the peptide subpocket of the CXCR4:CVX15 crystal structure.

Cox BD, Prosser AR, Katzman BM, Alcaraz AA, Liotta DC, Wilson LJ, Snyder JP.

Chembiochem. 2014 Jul 21;15(11):1614-20. doi: 10.1002/cbic.201402056. Epub 2014 Jul 2.

PMID:
24990206
4.

Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists.

Våbenø J, Haug BE, Rosenkilde MM.

Future Med Chem. 2015;7(10):1261-83. doi: 10.4155/fmc.15.64. Review.

PMID:
26144264
5.

Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of phidianidine a as a new CXCR4 ligand exhibiting antagonist activity.

Vitale RM, Gatti M, Carbone M, Barbieri F, Felicità V, Gavagnin M, Florio T, Amodeo P.

ACS Chem Biol. 2013 Dec 20;8(12):2762-70. doi: 10.1021/cb400521b. Epub 2013 Oct 30.

PMID:
24102412
6.

Small molecule inhibitors of CXCR4.

Debnath B, Xu S, Grande F, Garofalo A, Neamati N.

Theranostics. 2013;3(1):47-75. doi: 10.7150/thno.5376. Epub 2013 Jan 15. Review.

7.

Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies.

Hatse S, Princen K, Liekens S, Vermeire K, De Clercq E, Schols D.

Cytometry A. 2004 Oct;61(2):178-88.

8.

Ligand-guided optimization of CXCR4 homology models for virtual screening using a multiple chemotype approach.

Neves MA, Simões S, Sá e Melo ML.

J Comput Aided Mol Des. 2010 Dec;24(12):1023-33. doi: 10.1007/s10822-010-9393-x. Epub 2010 Oct 20.

PMID:
20960031
9.

Development of a unique small molecule modulator of CXCR4.

Liang Z, Zhan W, Zhu A, Yoon Y, Lin S, Sasaki M, Klapproth JM, Yang H, Grossniklaus HE, Xu J, Rojas M, Voll RJ, Goodman MM, Arrendale RF, Liu J, Yun CC, Snyder JP, Liotta DC, Shim H.

PLoS One. 2012;7(4):e34038. doi: 10.1371/journal.pone.0034038. Epub 2012 Apr 2.

10.

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.

Burger M, Hartmann T, Krome M, Rawluk J, Tamamura H, Fujii N, Kipps TJ, Burger JA.

Blood. 2005 Sep 1;106(5):1824-30. Epub 2005 May 19.

11.

Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design.

Veldkamp CT, Ziarek JJ, Peterson FC, Chen Y, Volkman BF.

J Am Chem Soc. 2010 Jun 2;132(21):7242-3. doi: 10.1021/ja1002263.

12.

Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.

Zabel BA, Wang Y, Lewén S, Berahovich RD, Penfold ME, Zhang P, Powers J, Summers BC, Miao Z, Zhao B, Jalili A, Janowska-Wieczorek A, Jaen JC, Schall TJ.

J Immunol. 2009 Sep 1;183(5):3204-11. doi: 10.4049/jimmunol.0900269. Epub 2009 Jul 29.

13.

Discovery of small molecule CXCR4 antagonists.

Zhan W, Liang Z, Zhu A, Kurtkaya S, Shim H, Snyder JP, Liotta DC.

J Med Chem. 2007 Nov 15;50(23):5655-64. Epub 2007 Oct 24.

PMID:
17958344
14.

Small molecule CXCR4 chemokine receptor antagonists: developing drug candidates.

Khan A, Greenman J, Archibald SJ.

Curr Med Chem. 2007;14(21):2257-77. Review.

PMID:
17896975
15.

Structure-based development of antagonists for chemokine receptor CXCR4.

Zhang C, Hou T, Feng Z, Li Y.

Curr Comput Aided Drug Des. 2013 Mar;9(1):60-75. Review.

PMID:
22734712
16.

Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells.

Kim J, Yip ML, Shen X, Li H, Hsin LY, Labarge S, Heinrich EL, Lee W, Lu J, Vaidehi N.

PLoS One. 2012;7(2):e31004. doi: 10.1371/journal.pone.0031004. Epub 2012 Feb 3.

17.
18.

Identifying modulators of CXC receptors 3 and 4 with tailored selectivity using multi-target docking.

Schmidt D, Bernat V, Brox R, Tschammer N, Kolb P.

ACS Chem Biol. 2015 Mar 20;10(3):715-24. doi: 10.1021/cb500577j. Epub 2014 Dec 5.

PMID:
25398025
19.

The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection.

Patrussi L, Baldari CT.

Curr Med Chem. 2011;18(4):497-512. Review.

PMID:
21143114
20.

Azamacrocyclic metal complexes as CXCR4 antagonists.

Tanaka T, Narumi T, Ozaki T, Sohma A, Ohashi N, Hashimoto C, Itotani K, Nomura W, Murakami T, Yamamoto N, Tamamura H.

ChemMedChem. 2011 May 2;6(5):834-9. doi: 10.1002/cmdc.201000548. Epub 2011 Feb 10.

PMID:
21312334
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