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Results: 1 to 20 of 101

1.

Heterotrimeric G-protein, Gα16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.

Avasarala S, Bikkavilli RK, Van Scoyk M, Zhang W, Lapite A, Hostetter L, Byers JT, Heasley LE, Sohn JW, Winn RA.

PLoS One. 2013 Oct 18;8(10):e76895. doi: 10.1371/journal.pone.0076895. eCollection 2013.

PMID:
24204697
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.

Tennis MA, Van Scoyk MM, Freeman SV, Vandervest KM, Nemenoff RA, Winn RA.

Mol Cancer Res. 2010 Jun;8(6):833-43. doi: 10.1158/1541-7786.MCR-09-0400. Epub 2010 May 25.

PMID:
20501643
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.

Winn RA, Van Scoyk M, Hammond M, Rodriguez K, Crossno JT Jr, Heasley LE, Nemenoff RA.

J Biol Chem. 2006 Sep 15;281(37):26943-50. Epub 2006 Jul 11.

PMID:
16835228
[PubMed - indexed for MEDLINE]
Free Article
4.

Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation.

Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE.

J Biol Chem. 2005 May 20;280(20):19625-34. Epub 2005 Feb 10.

PMID:
15705594
[PubMed - indexed for MEDLINE]
Free Article
5.

Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1.

Tennis MA, Van Scoyk M, Heasley LE, Vandervest K, Weiser-Evans M, Freeman S, Keith RL, Simpson P, Nemenoff RA, Winn RA.

Neoplasia. 2010 Mar;12(3):244-53.

PMID:
20234818
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression.

Avasarala S, Van Scoyk M, Wang J, Sechler M, Vandervest K, Brzezinski C, Weekes C, Edwards MG, Arcaroli J, Davis RE, Bikkavilli RK, Winn RA.

Biol Open. 2013 May 22;2(7):675-85. doi: 10.1242/bio.20134507. Print 2013 Jul 15.

PMID:
23862015
[PubMed]
Free PMC Article
7.

Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.

Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons DM, You L.

BMC Cancer. 2013 Jul 1;13:316. doi: 10.1186/1471-2407-13-316.

PMID:
23815780
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.

Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA, Reyland ME.

Cancer Res. 2011 Mar 15;71(6):2087-97. doi: 10.1158/0008-5472.CAN-10-1511. Epub 2011 Feb 18.

PMID:
21335545
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.

Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P.

BMC Mol Biol. 2008 Jan 23;9:11. doi: 10.1186/1471-2199-9-11.

PMID:
18215320
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

E-cadherin negatively regulates neoplastic growth in non-small cell lung cancer: role of Rho GTPases.

Asnaghi L, Vass WC, Quadri R, Day PM, Qian X, Braverman R, Papageorge AG, Lowy DR.

Oncogene. 2010 May 13;29(19):2760-71. doi: 10.1038/onc.2010.39. Epub 2010 Mar 15.

PMID:
20228844
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.

Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MC, Nemenoff RA.

Neoplasia. 2010 Mar;12(3):224-34.

PMID:
20234816
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS).

Liu AM, Lo RK, Lee MM, Wang Y, Yeung WW, Ho MK, Su Y, Ye RD, Wong YH.

Cell Signal. 2010 Oct;22(10):1448-58. doi: 10.1016/j.cellsig.2010.05.013.

PMID:
20639119
[PubMed - indexed for MEDLINE]
13.

Inositol pentakisphosphate mediates Wnt/beta-catenin signaling.

Gao Y, Wang HY.

J Biol Chem. 2007 Sep 7;282(36):26490-502. Epub 2007 Jun 26.

PMID:
17595165
[PubMed - indexed for MEDLINE]
Free Article
14.

Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy.

Thomson S, Petti F, Sujka-Kwok I, Epstein D, Haley JD.

Clin Exp Metastasis. 2008;25(8):843-54. doi: 10.1007/s10585-008-9200-4. Epub 2008 Aug 12.

PMID:
18696232
[PubMed - indexed for MEDLINE]
15.

Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.

Toyokawa G, Cho HS, Masuda K, Yamane Y, Yoshimatsu M, Hayami S, Takawa M, Iwai Y, Daigo Y, Tsuchiya E, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BA, Nakamura Y, Hamamoto R.

Neoplasia. 2011 Oct;13(10):887-98.

PMID:
22028615
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.

Zuo H, Chan GP, Zhu J, Yeung WW, Chan AS, Ammer H, Wong YH.

Cell Commun Signal. 2013 Aug 15;11:59. doi: 10.1186/1478-811X-11-59.

PMID:
23947369
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Frizzled receptors signal through G proteins.

Nichols AS, Floyd DH, Bruinsma SP, Narzinski K, Baranski TJ.

Cell Signal. 2013 Jun;25(6):1468-75. doi: 10.1016/j.cellsig.2013.03.009. Epub 2013 Mar 19.

PMID:
23524329
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma.

Akiri G, Cherian MM, Vijayakumar S, Liu G, Bafico A, Aaronson SA.

Oncogene. 2009 May 28;28(21):2163-72. doi: 10.1038/onc.2009.82. Epub 2009 Apr 20.

PMID:
19377513
[PubMed - indexed for MEDLINE]
19.

Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab.

Chen G, Kronenberger P, Teugels E, Umelo IA, De Grève J.

BMC Med. 2012 Mar 21;10:28. doi: 10.1186/1741-7015-10-28.

PMID:
22436374
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.

Lo RK, Cheung H, Wong YH.

J Biol Chem. 2003 Dec 26;278(52):52154-65. Epub 2003 Oct 9.

PMID:
14551213
[PubMed - indexed for MEDLINE]
Free Article

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