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Plasma S100A8/A9 correlates with blood neutrophil counts, traditional risk factors, and cardiovascular disease in middle-aged healthy individuals.

Cotoi OS, Dunér P, Ko N, Hedblad B, Nilsson J, Björkbacka H, Schiopu A.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):202-10. doi: 10.1161/ATVBAHA.113.302432. Epub 2013 Nov 7.


High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density.

Hirata A, Kishida K, Nakatsuji H, Hiuge-Shimizu A, Funahashi T, Shimomura I.

Diabetes Res Clin Pract. 2012 Jul;97(1):82-90. doi: 10.1016/j.diabres.2012.01.026. Epub 2012 Feb 12.


S100A8 and S100A9: DAMPs at the crossroads between innate immunity, traditional risk factors, and cardiovascular disease.

Schiopu A, Cotoi OS.

Mediators Inflamm. 2013;2013:828354. doi: 10.1155/2013/828354. Epub 2013 Dec 22. Review.


Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina.

Miyamoto S, Ueda M, Ikemoto M, Naruko T, Itoh A, Tamaki S, Nohara R, Terasaki F, Sasayama S, Fujita M.

Heart. 2008 Aug;94(8):1002-7. doi: 10.1136/hrt.2007.121640. Epub 2008 Feb 28.


Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patients with inactive systemic lupus erythematosus.

Tydén H, Lood C, Gullstrand B, Jönsen A, Nived O, Sturfelt G, Truedsson L, Ivars F, Leanderson T, Bengtsson AA.

Rheumatology (Oxford). 2013 Nov;52(11):2048-55. doi: 10.1093/rheumatology/ket263. Epub 2013 Aug 13.


Phagocyte-specific S100A8/A9 protein levels during disease exacerbations and infections in systemic lupus erythematosus.

Soyfoo MS, Roth J, Vogl T, Pochet R, Decaux G.

J Rheumatol. 2009 Oct;36(10):2190-4. doi: 10.3899/jrheum.081302. Epub 2009 Sep 15.


Carotid plaque, intima-media thickness, and incident aortic stenosis: a prospective cohort study.

Martinsson A, Östling G, Persson M, Sundquist K, Andersson C, Melander O, Engström G, Hedblad B, Smith JG.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2343-8. doi: 10.1161/ATVBAHA.114.304015. Epub 2014 Aug 14.


S100A8/A9 complex as a new biomarker in prediction of mortality in elderly patients with severe heart failure.

Ma LP, Haugen E, Ikemoto M, Fujita M, Terasaki F, Fu M.

Int J Cardiol. 2012 Feb 23;155(1):26-32. doi: 10.1016/j.ijcard.2011.01.082. Epub 2011 Feb 18.


High levels of S100A12 are associated with recent plaque symptomatology in patients with carotid atherosclerosis.

Abbas A, Aukrust P, Dahl TB, Bjerkeli V, Sagen EB, Michelsen A, Russell D, Krohg-Sørensen K, Holm S, Skjelland M, Halvorsen B.

Stroke. 2012 May;43(5):1347-53. doi: 10.1161/STROKEAHA.111.642256. Epub 2012 Mar 1. Erratum in: Stroke. 2013 Jul;44(7):e82. Sørensen, Kirsten Krohg [corrected to Krohg-Sørensen, Kirsten].


Prognostic value of neutrophils in patients with asymptomatic carotid artery disease.

Mayer FJ, Gruenberger D, Schillinger M, Mannhalter C, Minar E, Koppensteiner R, Arbesú I, Niessner A, Hoke M.

Atherosclerosis. 2013 Dec;231(2):274-80. doi: 10.1016/j.atherosclerosis.2013.10.002. Epub 2013 Oct 11.


S100A8, S100A9, and the S100A8/A9 complex in circulating blood are not associated with prostate cancer risk-A re-evaluation study.

Ludwig S, Stephan C, Lein M, Loening SA, Jung K.

Prostate. 2007 Sep 1;67(12):1301-7.


Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis.

Benoit S, Toksoy A, Ahlmann M, Schmidt M, Sunderkötter C, Foell D, Pasparakis M, Roth J, Goebeler M.

Br J Dermatol. 2006 Jul;155(1):62-6.


T-helper 2 immunity is associated with reduced risk of myocardial infarction and stroke.

Engelbertsen D, Andersson L, Ljungcrantz I, Wigren M, Hedblad B, Nilsson J, Björkbacka H.

Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):637-44. doi: 10.1161/ATVBAHA.112.300871. Epub 2013 Jan 10.


Circulating CD40+ and CD86+ B cell subsets demonstrate opposing associations with risk of stroke.

Mantani PT, Ljungcrantz I, Andersson L, Alm R, Hedblad B, Björkbacka H, Nilsson J, Fredrikson GN.

Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):211-8. doi: 10.1161/ATVBAHA.113.302667. Epub 2013 Nov 7.


Low plasma testosterone and elevated carotid intima-media thickness: importance of low-grade inflammation in elderly men.

Soisson V, Brailly-Tabard S, Empana JP, Féart C, Ryan J, Bertrand M, Guiochon-Mantel A, Scarabin PY.

Atherosclerosis. 2012 Jul;223(1):244-9. doi: 10.1016/j.atherosclerosis.2012.05.009. Epub 2012 May 16.


Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion.

Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA.

J Immunol. 2003 Mar 15;170(6):3233-42.


Progression of carotid intima-media thickness as predictor of vascular events: results from the IMPROVE study.

Baldassarre D, Veglia F, Hamsten A, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Grossi E, Paoletti R, Tremoli E; IMPROVE Study Group.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2273-9. doi: 10.1161/ATVBAHA.113.301844. Epub 2013 Jul 3.


S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury.

Wu Y, Li Y, Zhang C, A X, Wang Y, Cui W, Li H, Du J.

Hypertension. 2014 Jun;63(6):1241-50. doi: 10.1161/HYPERTENSIONAHA.113.02843. Epub 2014 Apr 7.


Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis.

Ryckman C, McColl SR, Vandal K, de Médicis R, Lussier A, Poubelle PE, Tessier PA.

Arthritis Rheum. 2003 Aug;48(8):2310-20.

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