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Items: 1 to 20 of 102


VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.

Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD.

Blood. 2014 Jan 2;123(1):141-8. doi: 10.1182/blood-2013-07-514992. Epub 2013 Nov 7.


PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps.

Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, Wang Y.

J Exp Med. 2010 Aug 30;207(9):1853-62. doi: 10.1084/jem.20100239. Epub 2010 Aug 23.


Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.

Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9. doi: 10.1073/pnas.1301059110. Epub 2013 May 6.


ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.

Gandhi C, Motto DG, Jensen M, Lentz SR, Chauhan AK.

Blood. 2012 Dec 20;120(26):5224-30. doi: 10.1182/blood-2012-06-440255. Epub 2012 Sep 14.


Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev SA, Allis CD, Coonrod SA.

J Cell Biol. 2009 Jan 26;184(2):205-13. doi: 10.1083/jcb.200806072. Epub 2009 Jan 19.


Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury.

Huang H, Tohme S, Al-Khafaji AB, Tai S, Loughran P, Chen L, Wang S, Kim J, Billiar T, Wang Y, Tsung A.

Hepatology. 2015 Aug;62(2):600-14. doi: 10.1002/hep.27841. Epub 2015 May 29.


Diabetes primes neutrophils to undergo NETosis, which impairs wound healing.

Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD.

Nat Med. 2015 Jul;21(7):815-9. doi: 10.1038/nm.3887. Epub 2015 Jun 15.


Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.

De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD.

Blood. 2012 Dec 20;120(26):5217-23. doi: 10.1182/blood-2012-06-439935. Epub 2012 Aug 22.


PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures.

Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang Y.

Front Immunol. 2012 Oct 4;3:307. doi: 10.3389/fimmu.2012.00307. eCollection 2012.


The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration.

Mueller M, Herzog C, Larmann J, Schmitz M, Hilfiker-Kleiner D, Gessner JE, Theilmeier G.

Immunobiology. 2013 Sep;218(9):1131-8. doi: 10.1016/j.imbio.2013.03.006. Epub 2013 Mar 28.


Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility.

Sur Chowdhury C, Giaglis S, Walker UA, Buser A, Hahn S, Hasler P.

Arthritis Res Ther. 2014 Jun 13;16(3):R122. doi: 10.1186/ar4579.


Neutrophil extracellular traps promote deep vein thrombosis in mice.

Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD.

J Thromb Haemost. 2012 Jan;10(1):136-44. doi: 10.1111/j.1538-7836.2011.04544.x.


Peptidyl arginine deiminase-4 activation exacerbates kidney ischemia-reperfusion injury.

Ham A, Rabadi M, Kim M, Brown KM, Ma Z, D'Agati V, Lee HT.

Am J Physiol Renal Physiol. 2014 Nov 1;307(9):F1052-62. doi: 10.1152/ajprenal.00243.2014. Epub 2014 Aug 27.


PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock.

Martinod K, Fuchs TA, Zitomersky NL, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD.

Blood. 2015 Mar 19;125(12):1948-56. doi: 10.1182/blood-2014-07-587709. Epub 2015 Jan 26.


PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.

Hemmers S, Teijaro JR, Arandjelovic S, Mowen KA.

PLoS One. 2011;6(7):e22043. doi: 10.1371/journal.pone.0022043. Epub 2011 Jul 11.


ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice.

Khan MM, Motto DG, Lentz SR, Chauhan AK.

J Thromb Haemost. 2012 Aug;10(8):1665-71. doi: 10.1111/j.1538-7836.2012.04822.x.


von Willebrand factor directly interacts with DNA from neutrophil extracellular traps.

Grässle S, Huck V, Pappelbaum KI, Gorzelanny C, Aponte-Santamaría C, Baldauf C, Gräter F, Schneppenheim R, Obser T, Schneider SW.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1382-9. doi: 10.1161/ATVBAHA.113.303016. Epub 2014 May 1.


Extracellular chromatin is an important mediator of ischemic stroke in mice.

De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1884-91. doi: 10.1161/ATVBAHA.112.250993. Epub 2012 May 24.


Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury.

Busche MN, Stahl GL.

Ger Med Sci. 2010 Sep 8;8. pii: Doc20. doi: 10.3205/000109.


DNase, ADAMTS13, and iPAD4: good for the heart.

Zheng XL.

Blood. 2014 Jan 2;123(1):10-1. doi: 10.1182/blood-2013-11-538322. No abstract available.

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