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Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.

Feng HJ, Jounaidi Y, Haburcak M, Yang X, Forman SA.

Br J Pharmacol. 2014 Feb;171(3):789-98. doi: 10.1111/bph.12507.


Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currents.

Feng HJ, Macdonald RL.

J Biol Chem. 2010 Jul 30;285(31):23614-21. doi: 10.1074/jbc.M110.122564. Epub 2010 Jun 4.


Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization.

Feng HJ, Macdonald RL.

J Neurophysiol. 2004 Sep;92(3):1577-85. Epub 2004 May 19.


GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts.

Haas KF, Macdonald RL.

J Physiol. 1999 Jan 1;514 ( Pt 1):27-45. Erratum in: J Physiol. 2004 Aug 1;558(Pt 3):1013.


Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation.

Stewart D, Desai R, Cheng Q, Liu A, Forman SA.

Mol Pharmacol. 2008 Dec;74(6):1687-95. doi: 10.1124/mol.108.050500. Epub 2008 Sep 19.


State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.

Stewart DS, Hotta M, Desai R, Forman SA.

Mol Pharmacol. 2013 Jun;83(6):1200-8. doi: 10.1124/mol.112.084558. Epub 2013 Mar 22.


Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB.

Biochemistry. 2012 Jan 31;51(4):836-47. doi: 10.1021/bi201772m. Epub 2012 Jan 23.


Multiple actions of propofol on alphabetagamma and alphabetadelta GABAA receptors.

Feng HJ, Macdonald RL.

Mol Pharmacol. 2004 Dec;66(6):1517-24. Epub 2004 Aug 26.


Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.

Wohlfarth KM, Bianchi MT, Macdonald RL.

J Neurosci. 2002 Mar 1;22(5):1541-9.


Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.

Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S.

Br J Pharmacol. 2012 Apr;165(7):2228-43. doi: 10.1111/j.1476-5381.2011.01690.x.


The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor.

McGurk KA, Pistis M, Belelli D, Hope AG, Lambert JJ.

Br J Pharmacol. 1998 May;124(1):13-20.


GABAA receptor open-state conformation determines non-competitive antagonist binding.

Chen L, Xue L, Giacomini KM, Casida JE.

Toxicol Appl Pharmacol. 2011 Feb 1;250(3):221-8. doi: 10.1016/j.taap.2010.11.010. Epub 2010 Nov 25.


Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity.

Desai R, Ruesch D, Forman SA.

Anesthesiology. 2009 Oct;111(4):774-84. doi: 10.1097/ALN.0b013e3181b55fae.


Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents.

Feng HJ, Bianchi MT, Macdonald RL.

Mol Pharmacol. 2004 Oct;66(4):988-1003. Epub 2004 Jul 9.


Two etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.

Guitchounts G, Stewart DS, Forman SA.

Anesthesiology. 2012 Jun;116(6):1235-44. doi: 10.1097/ALN.0b013e3182567df3.

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