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Items: 1 to 20 of 99

1.

Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4482-91. doi: 10.1073/pnas.1313474110. Epub 2013 Nov 5.

2.

Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion.

Spessott WA, Sanmillan ML, McCormick ME, Patel N, Villanueva J, Zhang K, Nichols KE, Giraudo CG.

Blood. 2015 Mar 5;125(10):1566-77. doi: 10.1182/blood-2014-11-610816. Epub 2015 Jan 6.

PMID:
25564401
3.

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.

Côte M, Ménager MM, Burgess A, Mahlaoui N, Picard C, Schaffner C, Al-Manjomi F, Al-Harbi M, Alangari A, Le Deist F, Gennery AR, Prince N, Cariou A, Nitschke P, Blank U, El-Ghazali G, Ménasché G, Latour S, Fischer A, de Saint Basile G.

J Clin Invest. 2009 Dec;119(12):3765-73. doi: 10.1172/JCI40732. Epub 2009 Nov 2.

4.

Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.

D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths GM, Zur Stadt U, Bulfone-Paus S.

Eur J Immunol. 2013 Jan;43(1):194-208. doi: 10.1002/eji.201142343. Epub 2012 Dec 12.

5.

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.

Han L, Jiang T, Han GA, Malintan NT, Xie L, Wang L, Tse FW, Gaisano HY, Collins BM, Meunier FA, Sugita S.

Mol Biol Cell. 2009 Dec;20(23):4962-75. doi: 10.1091/mbc.E09-08-0712. Epub 2009 Oct 7.

6.

Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.

Dieckmann NM, Hackmann Y, Aricò M, Griffiths GM.

Traffic. 2015 Dec;16(12):1330-41. doi: 10.1111/tra.12337. Epub 2015 Nov 2.

PMID:
26771955
7.

Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.

Kögl T, Müller J, Jessen B, Schmitt-Graeff A, Janka G, Ehl S, zur Stadt U, Aichele P.

Blood. 2013 Jan 24;121(4):604-13. doi: 10.1182/blood-2012-07-441139. Epub 2012 Nov 27.

8.

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.

zur Stadt U, Rohr J, Seifert W, Koch F, Grieve S, Pagel J, Strauss J, Kasper B, Nürnberg G, Becker C, Maul-Pavicic A, Beutel K, Janka G, Griffiths G, Ehl S, Hennies HC.

Am J Hum Genet. 2009 Oct;85(4):482-92. doi: 10.1016/j.ajhg.2009.09.005.

9.

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.

Bin NR, Jung CH, Piggott C, Sugita S.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4610-5. doi: 10.1073/pnas.1214887110. Epub 2013 Mar 4.

10.

Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production.

Chiang SC, Theorell J, Entesarian M, Meeths M, Mastafa M, Al-Herz W, Frisk P, Gilmour KC, Ifversen M, Langenskiöld C, Machaczka M, Naqvi A, Payne J, Perez-Martinez A, Sabel M, Unal E, Unal S, Winiarski J, Nordenskjöld M, Ljunggren HG, Henter JI, Bryceson YT.

Blood. 2013 Feb 21;121(8):1345-56. doi: 10.1182/blood-2012-07-442558. Epub 2013 Jan 2.

11.

Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.

Hellewell AL, Foresti O, Gover N, Porter MY, Hewitt EW.

PLoS One. 2014 Jun 9;9(6):e98900. doi: 10.1371/journal.pone.0098900. eCollection 2014.

12.

An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2.

Müller ML, Chiang SC, Meeths M, Tesi B, Entesarian M, Nilsson D, Wood SM, Nordenskjöld M, Henter JI, Naqvi A, Bryceson YT.

Front Immunol. 2014 Jan 14;4:515. doi: 10.3389/fimmu.2013.00515. eCollection 2014 Jan 14.

13.

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.

Bryceson YT, Rudd E, Zheng C, Edner J, Ma D, Wood SM, Bechensteen AG, Boelens JJ, Celkan T, Farah RA, Hultenby K, Winiarski J, Roche PA, Nordenskjöld M, Henter JI, Long EO, Ljunggren HG.

Blood. 2007 Sep 15;110(6):1906-15. Epub 2007 May 24.

14.

Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules.

Dabrazhynetskaya A, Ma J, Guerreiro-Cacais AO, Arany Z, Rudd E, Henter JI, Karre K, Levitskaya J, Levitsky V.

J Cell Mol Med. 2012 Jan;16(1):129-41. doi: 10.1111/j.1582-4934.2011.01280.x.

15.

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases.

Rohr J, Beutel K, Maul-Pavicic A, Vraetz T, Thiel J, Warnatz K, Bondzio I, Gross-Wieltsch U, Schündeln M, Schütz B, Woessmann W, Groll AH, Strahm B, Pagel J, Speckmann C, Janka G, Griffiths G, Schwarz K, zur Stadt U, Ehl S.

Haematologica. 2010 Dec;95(12):2080-7. doi: 10.3324/haematol.2010.029389. Epub 2010 Sep 7.

16.

Unusual functional manifestations of a novel STX11 frameshift mutation in two infants with familial hemophagocytic lymphohistiocytosis type 4 (FHL4).

Macartney CA, Weitzman S, Wood SM, Bansal D, Steele M, Meeths M, Abdelhaleem M, Bryceson YT.

Pediatr Blood Cancer. 2011 Apr;56(4):654-7. doi: 10.1002/pbc.22676. Epub 2010 Dec 27.

PMID:
21298754
17.

Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes.

Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, Yasumi T, Tauchi H, Koh K, Sato M, Morimoto A, Heike T, Ishii E, Yasukawa M.

PLoS One. 2010 Nov 30;5(11):e14173. doi: 10.1371/journal.pone.0014173.

18.

The functions of Munc18-1 in regulated exocytosis.

Burgoyne RD, Barclay JW, Ciufo LF, Graham ME, Handley MT, Morgan A.

Ann N Y Acad Sci. 2009 Jan;1152:76-86. doi: 10.1111/j.1749-6632.2008.03987.x.

PMID:
19161378
19.

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.

Marsh RA, Satake N, Biroschak J, Jacobs T, Johnson J, Jordan MB, Bleesing JJ, Filipovich AH, Zhang K.

Pediatr Blood Cancer. 2010 Jul 15;55(1):134-40. doi: 10.1002/pbc.22499.

PMID:
20486178
20.

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity.

Arneson LN, Brickshawana A, Segovis CM, Schoon RA, Dick CJ, Leibson PJ.

J Immunol. 2007 Sep 15;179(6):3397-401.

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