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Results: 1 to 20 of 185

1.

Berberine slows cell growth in autosomal dominant polycystic kidney disease cells.

Bonon A, Mangolini A, Pinton P, Del Senno L, Aguiari G.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):668-74. doi: 10.1016/j.bbrc.2013.10.076. Epub 2013 Oct 31.

PMID:
24184483
[PubMed - indexed for MEDLINE]
2.

Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.

Leonhard WN, van der Wal A, Novalic Z, Kunnen SJ, Gansevoort RT, Breuning MH, de Heer E, Peters DJ.

Am J Physiol Renal Physiol. 2011 May;300(5):F1193-202. doi: 10.1152/ajprenal.00419.2010. Epub 2011 Feb 23.

PMID:
21345977
[PubMed - indexed for MEDLINE]
Free Article
3.

Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.

Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, Hensley HH, Ying W, Chimmanamada D, Serebriiskii IG, Golemis EA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. doi: 10.1073/pnas.1301904110. Epub 2013 Jul 15.

PMID:
23858461
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S.

Hum Mol Genet. 2008 Jun 1;17(11):1505-16. doi: 10.1093/hmg/ddn039. Epub 2008 Feb 7.

PMID:
18263604
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.

Aguiari G, Varani K, Bogo M, Mangolini A, Vincenzi F, Durante C, Gessi S, Sacchetto V, Catizone L, Harris P, Rizzuto R, Borea PA, Del Senno L.

Biochim Biophys Acta. 2009 Jun;1792(6):531-40. doi: 10.1016/j.bbadis.2009.03.001. Epub 2009 Mar 11.

PMID:
19285554
[PubMed - indexed for MEDLINE]
Free Article
6.

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

Park EY, Sung YH, Yang MH, Noh JY, Park SY, Lee TY, Yook YJ, Yoo KH, Roh KJ, Kim I, Hwang YH, Oh GT, Seong JK, Ahn C, Lee HW, Park JH.

J Biol Chem. 2009 Mar 13;284(11):7214-22. doi: 10.1074/jbc.M805890200. Epub 2008 Dec 20.

PMID:
19098310
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

Distefano G, Boca M, Rowe I, Wodarczyk C, Ma L, Piontek KB, Germino GG, Pandolfi PP, Boletta A.

Mol Cell Biol. 2009 May;29(9):2359-71. doi: 10.1128/MCB.01259-08. Epub 2009 Mar 2.

PMID:
19255143
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.

Bastos AP, Onuchic LF.

Braz J Med Biol Res. 2011 Jul;44(7):606-17. Epub 2011 May 27. Review.

PMID:
21625823
[PubMed - indexed for MEDLINE]
Free Article
9.

c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation.

Elliott J, Zheleznova NN, Wilson PD.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C522-9. doi: 10.1152/ajpcell.00163.2010. Epub 2011 Apr 20.

PMID:
21508333
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.

Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C.

BMC Nephrol. 2008 Aug 25;9:10. doi: 10.1186/1471-2369-9-10.

PMID:
18721488
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Multidrug therapy for polycystic kidney disease: a review and perspective.

Aguiari G, Catizone L, Del Senno L.

Am J Nephrol. 2013;37(2):175-82. doi: 10.1159/000346812. Epub 2013 Feb 15. Review.

PMID:
23428809
[PubMed - indexed for MEDLINE]
Free Article
12.

Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells.

Grimm DH, Karihaloo A, Cai Y, Somlo S, Cantley LG, Caplan MJ.

J Biol Chem. 2006 Jan 6;281(1):137-44. Epub 2005 Nov 8.

PMID:
16278216
[PubMed - indexed for MEDLINE]
Free Article
13.

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M.

Hepatology. 2010 May;51(5):1778-88. doi: 10.1002/hep.23511.

PMID:
20131403
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation.

Aguiari G, Bizzarri F, Bonon A, Mangolini A, Magri E, Pedriali M, Querzoli P, Somlo S, Harris PC, Catizone L, Del Senno L.

J Mol Med (Berl). 2012 Nov;90(11):1267-82. doi: 10.1007/s00109-012-0902-3. Epub 2012 May 9.

PMID:
22570239
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Rosiglitazone inhibits cell proliferation by inducing G1 cell cycle arrest and apoptosis in ADPKD cyst-lining epithelia cells.

Liu Y, Dai B, Fu L, Jia J, Mei C.

Basic Clin Pharmacol Toxicol. 2010 Jun;106(6):523-30. doi: 10.1111/j.1742-7843.2010.00539.x. Epub 2010 Feb 22.

PMID:
20210794
[PubMed - indexed for MEDLINE]
16.

Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.

Freedman BS, Lam AQ, Sundsbak JL, Iatrino R, Su X, Koon SJ, Wu M, Daheron L, Harris PC, Zhou J, Bonventre JV.

J Am Soc Nephrol. 2013 Oct;24(10):1571-86. doi: 10.1681/ASN.2012111089. Epub 2013 Sep 5.

PMID:
24009235
[PubMed - indexed for MEDLINE]
17.

Autosomal dominant polycystic kidney disease: clues to pathogenesis.

Harris PC.

Hum Mol Genet. 1999;8(10):1861-6. Review.

PMID:
10469838
[PubMed - indexed for MEDLINE]
Free Article
18.

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells.

Boletta A, Qian F, Onuchic LF, Bhunia AK, Phakdeekitcharoen B, Hanaoka K, Guggino W, Monaco L, Germino GG.

Mol Cell. 2000 Nov;6(5):1267-73.

PMID:
11106764
[PubMed - indexed for MEDLINE]
Free Article
19.

Rosiglitazone inhibits insulin-like growth factor‑1-induced polycystic kidney disease cell growth and p70S6 kinase activation.

Liu C, Zhang Y, Yuan L, Fu L, Mei C.

Mol Med Rep. 2013 Sep;8(3):861-4. doi: 10.3892/mmr.2013.1588. Epub 2013 Jul 16.

PMID:
23864113
[PubMed - indexed for MEDLINE]
20.

Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells.

Yamaguchi T, Reif GA, Calvet JP, Wallace DP.

Am J Physiol Renal Physiol. 2010 Nov;299(5):F944-51. doi: 10.1152/ajprenal.00387.2010. Epub 2010 Sep 1.

PMID:
20810616
[PubMed - indexed for MEDLINE]
Free PMC Article

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