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Results: 1 to 20 of 114

1.

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.

De Rijck J, de Kogel C, Demeulemeester J, Vets S, El Ashkar S, Malani N, Bushman FD, Landuyt B, Husson SJ, Busschots K, Gijsbers R, Debyser Z.

Cell Rep. 2013 Nov 27;5(4):886-94. doi: 10.1016/j.celrep.2013.09.040. Epub 2013 Oct 31.

PMID:
24183673
[PubMed - indexed for MEDLINE]
Free Article
2.

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

Gupta SS, Maetzig T, Maertens GN, Sharif A, Rothe M, Weidner-Glunde M, Galla M, Schambach A, Cherepanov P, Schulz TF.

J Virol. 2013 Dec;87(23):12721-36. doi: 10.1128/JVI.01942-13. Epub 2013 Sep 18.

PMID:
24049186
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BET proteins promote efficient murine leukemia virus integration at transcription start sites.

Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41. doi: 10.1073/pnas.1307157110. Epub 2013 Jul 1.

PMID:
23818621
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.

Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ.

Nucleic Acids Res. 2014;42(9):5917-28. doi: 10.1093/nar/gku175. Epub 2014 Mar 12.

PMID:
24623816
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.

Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M.

Cell Cycle. 2013 Feb 1;12(3):452-62. doi: 10.4161/cc.23309. Epub 2012 Feb 1.

PMID:
23255218
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements.

El Ashkar S, De Rijck J, Demeulemeester J, Vets S, Madlala P, Cermakova K, Debyser Z, Gijsbers R.

Mol Ther Nucleic Acids. 2014 Jul 29;3:e179. doi: 10.1038/mtna.2014.33.

PMID:
25072693
[PubMed]
Free PMC Article
7.

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes.

Larue RC, Plumb MR, Crowe BL, Shkriabai N, Sharma A, DiFiore J, Malani N, Aiyer SS, Roth MJ, Bushman FD, Foster MP, Kvaratskhelia M.

Nucleic Acids Res. 2014 Apr;42(8):4868-81. doi: 10.1093/nar/gku135. Epub 2014 Feb 11.

PMID:
24520112
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Enhancers are major targets for murine leukemia virus vector integration.

De Ravin SS, Su L, Theobald N, Choi U, Macpherson JL, Poidinger M, Symonds G, Pond SM, Ferris AL, Hughes SH, Malech HL, Wu X.

J Virol. 2014 Apr;88(8):4504-13. doi: 10.1128/JVI.00011-14. Epub 2014 Feb 5.

PMID:
24501411
[PubMed - indexed for MEDLINE]
9.

Retroviral DNA integration: viral and cellular determinants of target-site selection.

Lewinski MK, Yamashita M, Emerman M, Ciuffi A, Marshall H, Crawford G, Collins F, Shinn P, Leipzig J, Hannenhalli S, Berry CC, Ecker JR, Bushman FD.

PLoS Pathog. 2006 Jun;2(6):e60. Epub 2006 Jun 23.

PMID:
16789841
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors.

Studamire B, Goff SP.

Retrovirology. 2008 Jun 13;5:48. doi: 10.1186/1742-4690-5-48.

PMID:
18554410
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

When are the BET factors the most sensitive to bromodomain inhibitors?

Khochbin S.

Transcription. 2013 Mar-Apr;4(2):54-7. doi: 10.4161/trns.23191. Epub 2013 Feb 14.

PMID:
23412362
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression.

Michaeloudes C, Mercado N, Clarke C, Bhavsar PK, Adcock IM, Barnes PJ, Chung KF.

J Immunol. 2014 May 15;192(10):4913-20. doi: 10.4049/jimmunol.1301984. Epub 2014 Apr 14.

PMID:
24733848
[PubMed - indexed for MEDLINE]
13.

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.

Mitchell RS, Beitzel BF, Schroder AR, Shinn P, Chen H, Berry CC, Ecker JR, Bushman FD.

PLoS Biol. 2004 Aug;2(8):E234. Epub 2004 Aug 17.

PMID:
15314653
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells.

Beard BC, Dickerson D, Beebe K, Gooch C, Fletcher J, Okbinoglu T, Miller DG, Jacobs MA, Kaul R, Kiem HP, Trobridge GD.

Mol Ther. 2007 Jul;15(7):1356-65. Epub 2007 Apr 17.

PMID:
17440443
[PubMed - indexed for MEDLINE]
15.

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes.

Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM.

J Virol. 2004 Sep;78(17):9524-37.

PMID:
15308744
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor.

Cavalluzzo C, Christ F, Voet A, Sharma A, Singh BK, Zhang KY, Lescrinier E, De Maeyer M, Debyser Z, Van der Eycken E.

J Pept Sci. 2013 Oct;19(10):651-8. doi: 10.1002/psc.2543. Epub 2013 Aug 27.

PMID:
24014475
[PubMed - indexed for MEDLINE]
17.

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.

J Biol Chem. 2011 Dec 2;286(48):41812-25. doi: 10.1074/jbc.M111.255711. Epub 2011 Oct 10.

PMID:
21987578
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag.

Schneider WM, Brzezinski JD, Aiyer S, Malani N, Gyuricza M, Bushman FD, Roth MJ.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9487-92. doi: 10.1073/pnas.1221736110. Epub 2013 May 9.

PMID:
23661057
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Integrase, LEDGF/p75 and HIV replication.

Poeschla EM.

Cell Mol Life Sci. 2008 May;65(9):1403-24. doi: 10.1007/s00018-008-7540-5. Review.

PMID:
18264802
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z.

PLoS Pathog. 2007 Mar;3(3):e47.

PMID:
17397262
[PubMed - indexed for MEDLINE]
Free PMC Article

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