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Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

Holden NS, George T, Rider CF, Chandrasekhar A, Shah S, Kaur M, Johnson M, Siderovski DP, Leigh R, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2014 Jan;348(1):12-24. doi: 10.1124/jpet.113.204586. Epub 2013 Oct 25.


β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11.


Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists.

Rider CF, King EM, Holden NS, Giembycz MA, Newton R.

J Pharmacol Exp Ther. 2011 Sep;338(3):860-9. doi: 10.1124/jpet.111.181016. Epub 2011 May 27.


Enhancement of inflammatory mediator release by beta(2)-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action.

Holden NS, Rider CF, Bell MJ, Velayudhan J, King EM, Kaur M, Salmon M, Giembycz MA, Newton R.

Br J Pharmacol. 2010 May;160(2):410-20. doi: 10.1111/j.1476-5381.2010.00708.x.


Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.

Rider CF, Shah S, Miller-Larsson A, Giembycz MA, Newton R.

PLoS One. 2015 Jan 27;10(1):e0116773. doi: 10.1371/journal.pone.0116773. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0128728.


Superiority of combined phosphodiesterase PDE3/PDE4 inhibition over PDE4 inhibition alone on glucocorticoid- and long-acting β2-adrenoceptor agonist-induced gene expression in human airway epithelial cells.

BinMahfouz H, Borthakur B, Yan D, George T, Giembycz MA, Newton R.

Mol Pharmacol. 2015 Jan;87(1):64-76. doi: 10.1124/mol.114.093393. Epub 2014 Oct 16.


Modulation of transcriptional responses by poly(I:C) and human rhinovirus: effect of long-acting β₂-adrenoceptor agonists.

Rider CF, Miller-Larsson A, Proud D, Giembycz MA, Newton R.

Eur J Pharmacol. 2013 May 15;708(1-3):60-7. doi: 10.1016/j.ejphar.2013.02.056. Epub 2013 Mar 20.


Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.

Nino G, Hu A, Grunstein JS, Grunstein MM.

J Allergy Clin Immunol. 2010 May;125(5):1020-7. doi: 10.1016/j.jaci.2010.02.007. Epub 2010 Apr 14.


Budesonide/formoterol maintenance and reliever therapy in Asian patients (aged ≥16 years) with asthma: a sub-analysis of the COSMOS study.

Vogelmeier C, Naya I, Ekelund J.

Clin Drug Investig. 2012 Jul 1;32(7):439-49. doi: 10.2165/11598840-000000000-00000.


Long-acting beta 2 agonists suppress IP-10 expression in human bronchial epithelial cells.

Chien JW, Chu YT, Yang SN, Kuo CH, Wang WL, Kuo PL, Jong YJ, Hung CH.

J Investig Med. 2012 Oct;60(7):1048-53. doi: 10.2310/JIM.0b013e3182673ff9.


Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements.

Edwards MR, Haas J, Panettieri RA Jr, Johnson M, Johnston SL.

J Biol Chem. 2007 May 25;282(21):15366-75. Epub 2007 Mar 29.


Corticosteroids plus long-acting β2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium.

Kan-O K, Matsumoto K, Inoue H, Fukuyama S, Asai Y, Watanabe W, Kurokawa M, Araya J, Kuwano K, Nakanishi Y.

Int Arch Allergy Immunol. 2013;160(1):27-36. doi: 10.1159/000338430. Epub 2012 Aug 31.


Inhibition by salmeterol and cilomilast of fluticasone-enhanced IP-10 release in airway epithelial cells.

Reddy PJ, Aksoy MO, Yang Y, Li XX, Ji R, Kelsen SG.

COPD. 2008 Feb;5(1):5-11. doi: 10.1080/15412550701817573.


Expression of interleukin-16 by human epithelial cells. Inhibition by dexamethasone.

Arima M, Plitt J, Stellato C, Bickel C, Motojima S, Makino S, Fukuda T, Schleimer RP.

Am J Respir Cell Mol Biol. 1999 Dec;21(6):684-92.


Downregulation by a long-acting beta2-adrenergic receptor agonist and corticosteroid of Staphylococcus aureus-induced airway epithelial inflammatory mediator production.

Fragaki K, Kileztky C, Trentesaux C, Zahm JM, Bajolet O, Johnson M, Puchelle E.

Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L11-8. Epub 2006 Feb 17.


Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.

Wilson SM, Shen P, Rider CF, Traves SL, Proud D, Newton R, Giembycz MA.

J Immunol. 2009 Nov 15;183(10):6788-99. doi: 10.4049/jimmunol.0902738. Epub 2009 Oct 30.

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