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Results: 1 to 20 of 133

1.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.

Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27.

PMID:
24161930
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity.

Liu P, Guo J, Gan W, Wei W.

Protein Cell. 2014 Mar;5(3):171-7. doi: 10.1007/s13238-014-0021-8.

PMID:
24481632
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.

PMID:
23928304
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

PMID:
17599906
[PubMed - indexed for MEDLINE]
Free Article
5.

Crosstalk between mTOR complexes.

Xie J, Proud CG.

Nat Cell Biol. 2013 Nov;15(11):1263-5. doi: 10.1038/ncb2877.

PMID:
24189516
[PubMed - indexed for MEDLINE]
6.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

Tu Y, Ji C, Yang B, Yang Z, Gu H, Lu CC, Wang R, Su ZL, Chen B, Sun WL, Xia JP, Bi ZG, He L.

Mol Cancer. 2013 Dec 24;12(1):172. doi: 10.1186/1476-4598-12-172.

PMID:
24365180
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.

Chen CH, Sarbassov dos D.

J Biol Chem. 2011 Nov 18;286(46):40386-94. doi: 10.1074/jbc.M111.282590. Epub 2011 Sep 30.

PMID:
21965657
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.

Misra UK, Pizzo SV.

PLoS One. 2012;7(12):e51735. doi: 10.1371/journal.pone.0051735. Epub 2012 Dec 14.

PMID:
23272152
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

mTORC2 targets AGC kinases through Sin1-dependent recruitment.

Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ.

Biochem J. 2011 Oct 15;439(2):287-97. doi: 10.1042/BJ20110678.

PMID:
21806543
[PubMed - indexed for MEDLINE]
Free Article
10.

mTOR complex 2 mediates Akt phosphorylation that requires PKCε in adult cardiac muscle cells.

Moschella PC, McKillop J, Pleasant DL, Harston RK, Balasubramanian S, Kuppuswamy D.

Cell Signal. 2013 Sep;25(9):1904-12. doi: 10.1016/j.cellsig.2013.05.001. Epub 2013 May 11.

PMID:
23673367
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.

Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.

Mol Cell Biol. 2009 Mar;29(6):1411-20. doi: 10.1128/MCB.00782-08. Epub 2008 Dec 29.

PMID:
19114562
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.

Mol Cell. 2012 Dec 28;48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8.

PMID:
23142081
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.

Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K.

Sci Signal. 2012 Mar 27;5(217):ra25. doi: 10.1126/scisignal.2002469.

PMID:
22457331
[PubMed - indexed for MEDLINE]
Free Article
14.

Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines.

Murai A, Asa SA, Kodama A, Hirata A, Yanai T, Sakai H.

BMC Vet Res. 2012 Jul 29;8:128. doi: 10.1186/1746-6148-8-128.

PMID:
22839755
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Inhibition of mTORC1 by SU6656, the selective Src kinase inhibitor, is not accompanied by activation of Akt/PKB signalling in melanoma cells.

Ondrušová L, Réda J, Záková P, Tuháčková Z.

Folia Biol (Praha). 2013;59(4):162-7.

PMID:
24093774
[PubMed - indexed for MEDLINE]
Free Article
16.

mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.

Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.

J Endocrinol. 2013 Jan 2;216(1):21-9. doi: 10.1530/JOE-12-0351. Print 2013 Jan.

PMID:
23092880
[PubMed - indexed for MEDLINE]
Free Article
17.

Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.

Jeon YH, Park YH, Kwon JH, Lee JH, Kim IY.

Biochim Biophys Acta. 2013 Oct;1833(10):2135-42. doi: 10.1016/j.bbamcr.2013.05.005. Epub 2013 May 13.

PMID:
23680186
[PubMed - indexed for MEDLINE]
Free Article
18.

mTORC2-PKBα/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis.

Chen L, Wu J, Pier E, Zhao Y, Shen Z.

J Invest Dermatol. 2013 Feb;133(2):418-28. doi: 10.1038/jid.2012.333. Epub 2012 Dec 6.

PMID:
23223135
[PubMed - indexed for MEDLINE]
Free Article
19.

Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).

Destefano MA, Jacinto E.

Biochem Soc Trans. 2013 Aug;41(4):896-901. doi: 10.1042/BST20130018. Review.

PMID:
23863152
[PubMed - indexed for MEDLINE]
20.

Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle.

Hsieh CT, Chuang JH, Yang WC, Yin Y, Lin Y.

Cell Signal. 2014 Jul;26(7):1400-8. doi: 10.1016/j.cellsig.2014.03.004. Epub 2014 Mar 17.

PMID:
24650522
[PubMed - indexed for MEDLINE]

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