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Items: 1 to 20 of 124


Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end.

Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO.

J Biol Chem. 2013 Dec 20;288(51):36385-97. doi: 10.1074/jbc.M113.513614. Epub 2013 Oct 22.


The crystal structure of the signal recognition particle in complex with its receptor.

Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N.

Science. 2011 Feb 18;331(6019):881-6. doi: 10.1126/science.1196473.


Fingerloop activates cargo delivery and unloading during cotranslational protein targeting.

Ariosa AR, Duncan SS, Saraogi I, Lu X, Brown A, Phillips GJ, Shan SO.

Mol Biol Cell. 2013 Jan;24(2):63-73. doi: 10.1091/mbc.E12-06-0434. Epub 2012 Nov 7.


SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction.

Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P.

Nat Struct Mol Biol. 2008 Sep;15(9):916-23.


Multiple conformational switches in a GTPase complex control co-translational protein targeting.

Zhang X, Schaffitzel C, Ban N, Shan SO.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1754-9. doi: 10.1073/pnas.0808573106. Epub 2009 Jan 27.


Multi-state targeting machinery govern the fidelity and efficiency of protein localization.

Yang M, Pang X, Han K.

Adv Exp Med Biol. 2014;805:385-409. doi: 10.1007/978-3-319-02970-2_16.


Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting.

Lam VQ, Akopian D, Rome M, Henningsen D, Shan SO.

J Cell Biol. 2010 Aug 23;190(4):623-35. doi: 10.1083/jcb.201004129.


Interaction of signal-recognition particle 54 GTPase domain and signal-recognition particle RNA in the free signal-recognition particle.

Hainzl T, Huang S, Sauer-Eriksson AE.

Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14911-6. Epub 2007 Sep 10.


The structural basis of FtsY recruitment and GTPase activation by SRP RNA.

Voigts-Hoffmann F, Schmitz N, Shen K, Shan SO, Ataide SF, Ban N.

Mol Cell. 2013 Dec 12;52(5):643-54. doi: 10.1016/j.molcel.2013.10.005. Epub 2013 Nov 7.


Induced nucleotide specificity in a GTPase.

Shan SO, Walter P.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4480-5. Epub 2003 Mar 27.


RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle.

Spanggord RJ, Siu F, Ke A, Doudna JA.

Nat Struct Mol Biol. 2005 Dec;12(12):1116-22. Epub 2005 Nov 20.


The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.

Bradshaw N, Walter P.

Mol Biol Cell. 2007 Jul;18(7):2728-34. Epub 2007 May 16.


A distinct mechanism to achieve efficient signal recognition particle (SRP)-SRP receptor interaction by the chloroplast srp pathway.

Jaru-Ampornpan P, Nguyen TX, Shan SO.

Mol Biol Cell. 2009 Sep;20(17):3965-73. doi: 10.1091/mbc.E08-10-0989. Epub 2009 Jul 8.


Mechanism of association and reciprocal activation of two GTPases.

Shan SO, Stroud RM, Walter P.

PLoS Biol. 2004 Oct;2(10):e320. Epub 2004 Sep 21.


Co-translational protein targeting by the signal recognition particle.

Shan SO, Walter P.

FEBS Lett. 2005 Feb 7;579(4):921-6. Review.


Conformational changes in the bacterial SRP receptor FtsY upon binding of guanine nucleotides and SRP.

Jagath JR, Rodnina MV, Wintermeyer W.

J Mol Biol. 2000 Jan 28;295(4):745-53.


Activated GTPase movement on an RNA scaffold drives co-translational protein targeting.

Shen K, Arslan S, Akopian D, Ha T, Shan SO.

Nature. 2012 Dec 13;492(7428):271-5. doi: 10.1038/nature11726.


Evidence for a novel GTPase priming step in the SRP protein targeting pathway.

Lu Y, Qi HY, Hyndman JB, Ulbrandt ND, Teplyakov A, Tomasevic N, Bernstein HD.

EMBO J. 2001 Dec 3;20(23):6724-34.

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