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Cardiovascular effects of 1 year of alagebrium and endurance exercise training in healthy older individuals.

Fujimoto N, Hastings JL, Carrick-Ranson G, Shafer KM, Shibata S, Bhella PS, Abdullah SM, Barkley KW, Adams-Huet B, Boyd KN, Livingston SA, Palmer D, Levine BD.

Circ Heart Fail. 2013 Nov;6(6):1155-64. doi: 10.1161/CIRCHEARTFAILURE.113.000440. Epub 2013 Oct 15.


Cardiovascular effects of 1 year of progressive and vigorous exercise training in previously sedentary individuals older than 65 years of age.

Fujimoto N, Prasad A, Hastings JL, Arbab-Zadeh A, Bhella PS, Shibata S, Palmer D, Levine BD.

Circulation. 2010 Nov 2;122(18):1797-805. doi: 10.1161/CIRCULATIONAHA.110.973784. Epub 2010 Oct 18.


Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction.

Fujimoto N, Prasad A, Hastings JL, Bhella PS, Shibata S, Palmer D, Levine BD.

Am Heart J. 2012 Dec;164(6):869-77. doi: 10.1016/j.ahj.2012.06.028. Epub 2012 Oct 29.


The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial.

Oudegeest-Sander MH, Olde Rikkert MG, Smits P, Thijssen DH, van Dijk AP, Levine BD, Hopman MT.

Exp Gerontol. 2013 Dec;48(12):1509-17.


Impact of lifelong exercise "dose" on left ventricular compliance and distensibility.

Bhella PS, Hastings JL, Fujimoto N, Shibata S, Carrick-Ranson G, Palmer MD, Boyd KN, Adams-Huet B, Levine BD.

J Am Coll Cardiol. 2014 Sep 23;64(12):1257-66. doi: 10.1016/j.jacc.2014.03.062.


The effect of 1 year of Alagebrium and moderate-intensity exercise training on left ventricular function during exercise in seniors: a randomized controlled trial.

Carrick-Ranson G, Fujimoto N, Shafer KM, Hastings JL, Shibata S, Palmer MD, Boyd K, Levine BD.

J Appl Physiol (1985). 2016 Aug 1;121(2):528-36. doi: 10.1152/japplphysiol.00021.2016. Epub 2016 Jul 8.


Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure.

Hartog JW, Willemsen S, van Veldhuisen DJ, Posma JL, van Wijk LM, Hummel YM, Hillege HL, Voors AA; BENEFICIAL investigators.

Eur J Heart Fail. 2011 Aug;13(8):899-908. doi: 10.1093/eurjhf/hfr067. Epub 2011 Jun 13.


Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial.

Kitzman DW, Brubaker PH, Herrington DM, Morgan TM, Stewart KP, Hundley WG, Abdelhamed A, Haykowsky MJ.

J Am Coll Cardiol. 2013 Aug 13;62(7):584-92. doi: 10.1016/j.jacc.2013.04.033. Epub 2013 May 9.


The effect of lifelong exercise dose on cardiovascular function during exercise.

Carrick-Ranson G, Hastings JL, Bhella PS, Fujimoto N, Shibata S, Palmer MD, Boyd K, Livingston S, Dijk E, Levine BD.

J Appl Physiol (1985). 2014 Apr 1;116(7):736-45. doi: 10.1152/japplphysiol.00342.2013. Epub 2014 Jan 23.


Enhanced left ventricular performance in endurance trained older men.

Seals DR, Hagberg JM, Spina RJ, Rogers MA, Schechtman KB, Ehsani AA.

Circulation. 1994 Jan;89(1):198-205.


PDE 5 inhibition with udenafil improves left ventricular systolic/diastolic functions and exercise capacity in patients with chronic heart failure with reduced ejection fraction; A 12-week, randomized, double-blind, placebo-controlled trial.

Kim KH, Kim HK, Hwang IC, Cho HJ, Je N, Kwon OM, Choi SJ, Lee SP, Kim YJ, Sohn DW.

Am Heart J. 2015 Jun;169(6):813-822.e3. doi: 10.1016/j.ahj.2015.03.018. Epub 2015 Apr 1.


Endurance exercise training augments diastolic filling at rest and during exercise in healthy young and older men.

Levy WC, Cerqueira MD, Abrass IB, Schwartz RS, Stratton JR.

Circulation. 1993 Jul;88(1):116-26.


Effects of age and aerobic fitness on myocardial lipid content.

Sarma S, Carrick-Ranson G, Fujimoto N, Adams-Huet B, Bhella PS, Hastings JL, Shafer KM, Shibata S, Boyd K, Palmer D, Szczepaniak EW, Szczepaniak LS, Levine BD.

Circ Cardiovasc Imaging. 2013 Nov;6(6):1048-55. doi: 10.1161/CIRCIMAGING.113.000565. Epub 2013 Sep 13.


Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function.

Erbs S, Höllriegel R, Linke A, Beck EB, Adams V, Gielen S, Möbius-Winkler S, Sandri M, Kränkel N, Hambrecht R, Schuler G.

Circ Heart Fail. 2010 Jul;3(4):486-94. doi: 10.1161/CIRCHEARTFAILURE.109.868992. Epub 2010 Apr 29.


Effects of Nebivolol on left ventricular function and exercise capacity in patients with non-ischaemic dilated cardiomyopathy. A randomised placebo-controlled study.

Patrianakos AP, Parthenakis FI, Mavrakis HE, Saatsaki M, Diakakis GF, Chlouverakis GI, Vardas PE.

Hellenic J Cardiol. 2005 May-Jun;46(3):199-207.


Effect of aging and physical activity on left ventricular compliance.

Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thomas JD, Palmer D, Levine BD.

Circulation. 2004 Sep 28;110(13):1799-805. Epub 2004 Sep 13.


Exercise training improves left ventricular diastolic filling in patients with dilated cardiomyopathy. Clinical and prognostic implications.

Belardinelli R, Georgiou D, Cianci G, Berman N, Ginzton L, Purcaro A.

Circulation. 1995 Jun 1;91(11):2775-84.

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